Riechen und Riechstörungen

Hummel, Thomas; Guerra, Nicole Power; Gunder, Nadine; Hähner, Antje; Menzel, Susanne

doi:10.1055/a-1957-3267

Cited by 4 publications

(6 citation statements)

References 457 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Psychophysical tests, most commonly in the form of orthonasal odor identification tests, are the gold standard in the evaluation of quantitative OD. These testing methods are based on the patient's response after exposure to an olfactory stimulus [40,48,49]. A wide range of different extended or screening tests are available worldwide, including the Sniffin' Sticks test (original version), the short olfactory screening test, the Connecticut Chemosensory Clinical Research Center (CC-CRC) test, the Smell Identification Test (SIT-40), previously known as University of Pennsylvania Smell Identification Test (UPSIT), the T&T Olfactometer, the Barcelona Smell Test (BAST-24), and the Brief Smell Identification Test (BSIT).…”

Section: Diagnosis Of Olfactory Dysfunctionmentioning

confidence: 99%

“…Furthermore, the evaluation of all different components of olfaction often enables the diagnosis of the underlying etiology. On the downside, these comprehensive tests are time-consuming and logistically demanding, and thus not commonly used in the everyday clinical practice [40,48,50,51]. In addition, it should be noted that having a (pre-COVID) baseline would be necessary for the objective evaluation of OD, but this is generally unavailable.…”

Section: Diagnosis Of Olfactory Dysfunctionmentioning

confidence: 99%

“…In another study focused on the recovery of olfactory function after COVID-19, Lechien and colleagues have monitored the prevalence of OD in the acute phase of infection (50.8%), and after 1 (18.7%) and 2 years (2.9%) using the Sniffin' Sticks test for odor identification [56]. Apart from subjective and psychophysical tests, objective testing methods such as imaging (mainly MRI and functional MRI) and electrophysiology tests (electroencephalograms and electro-olfactograms) can be used for diagnostic purposes and, more commonly, in the research setting [40,48].…”

Section: Diagnosis Of Olfactory Dysfunctionmentioning

confidence: 99%

See 2 more Smart Citations

The Molecular Basis of Olfactory Dysfunction in COVID-19 and Long COVID

Anastassopoulou,

Davaris,

Ferous

et al. 2024

Lifestyle Genomics

View full text Add to dashboard Cite

Olfactory dysfunction (OD) is not uncommon following viral infection. Herein, we explore the interplay of host genetics with viral correlates in coronavirus disease 2019 (COVID-19)- and long COVID-related OD, and its diagnosis and treatment that remain challenging. Two genes associated with olfaction, UGT2A1 and UGT2A2, appear to be involved in COVID-19-related anosmia, a hallmark symptom of acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly in the early stages of the pandemic. SARS-CoV-2 infects olfactory support cells, sustentacular and Bowman gland cells, that surround olfactory sensory neurons (OSNs) in the olfactory epithelium (OE) where the initial step of odor detection takes place. Anosmia primarily arises from the infection of support cells of the OE, followed by the deciliation and disruption of OE integrity, typically without OSN infection. Through the projected axons of OSNs, the virus could theoretically reach the olfactory bulb and brain, but current evidence points against this route. Intriguingly, SARS-CoV-2 infection of support cells leads to profound alterations in the nuclear architecture of OSNs, leading to the downregulation of odorant receptor-related genes, e.g., of Adcy3. Viral factors associated with the development of OD include spike protein aminoacidic changes, e.g., D614G, the first substitution that was selected early during SARS-CoV-2 evolution. More recent variants of the Omicron family are less likely to cause OD compared to Delta or Alpha, although OD has been associated with a milder disease course. OD is one of the most prevalent post-acute neurologic symptoms of SARS-CoV-2 infection. The tens of millions of people worldwide who have lingering problems with OD wait eagerly for effective new treatments that will restore their sense of smell which adds value to their quality of life.

show abstract

Section: Diagnosis Of Olfactory Dysfunctionmentioning

confidence: 99%

Section: Diagnosis Of Olfactory Dysfunctionmentioning

confidence: 99%

Section: Diagnosis Of Olfactory Dysfunctionmentioning

confidence: 99%

See 1 more Smart Citation

The Molecular Basis of Olfactory Dysfunction in COVID-19 and Long COVID

Anastassopoulou,

Davaris,

Ferous

et al. 2024

Lifestyle Genomics

View full text Add to dashboard Cite

show abstract

“…Olfactory dysfunction (OD) can be a result of a myriad of causes, including aging, chronic rhinosinusitis, traumatic brain injury, and upper respiratory tract infections. 1 Sino‐nasal disease is recognized as the most common etiology of olfactory dysfunction as it is seen in 62% of patients with OD, followed by post‐infectious olfactory dysfunction. 2 According to a recent systematic review and meta‐analysis, it was discovered that olfactory dysfunction affects approximately 22.2% of the general population.…”

Section: Introductionmentioning

confidence: 99%

Reliability and validity of the Arabic version of the brief version of the Questionnaire of Olfactory Disorders

Alsaleh,

Alfallaj,

Almousa

et al. 2024

Laryngoscope Investig Oto

View full text Add to dashboard Cite

BackgroundAn accessible self‐assessment questionnaire is needed to evaluate quality of life in olfactory dysfunction. The need to address this gap led to the development of the brief version of the Questionnaire of Olfactory Disorders (brief QOD), which holds particular value in the context of telemedicine.ObjectivesThe aim of this study is to examine the reliability and validity of the Arabic brief QOD.MethodsThis study included 307 patients suffering from olfactory dysfunction as well as a control group filled a questionnaire including demographic information, the olfaction Visual Analog Scale (VAS), the Sino‐nasal Outcome Test 22 (SNOT‐22) questionnaire, and the Arabic version of the brief QOD. The Arabic brief QOD's reliability was assessed using Cronbach's α to measure internal consistency. To evaluate test–retest reliability, the intraclass correlation coefficient (ICC) was employed. The discriminative ability: score differences between the two groups were analyzed. The validity Arabic brief QOD was evaluated by comparing it to the olfaction VAS.ResultsThe Cronbach's α coefficients were 0.757 for Questionnaire of Olfactory Disorders‐Parosmia (QOD‐P), 0.832 Questionnaire of Olfactory Disorders‐quality of life (QOD‐QoL), and 0.817 Questionnaire of Olfactory Disorders‐visual analog scale (QOD‐VAS). The reliability of the overall brief QOD was 0.93. The ICC exceeded the acceptable threshold of 0.7, indicating strong test–retest reliability. The highest correlation was observed between the SNOT‐22 and QOD total scores (r = 0.552 and p < .001) as well as between SNOT‐22 and QOD VAS (r = 0.512 and p < .001).ConclusionExcellent validity and reliability have been shown for the Arabic brief QOD as a self‐assessment tool assessing quality of life among olfactory dysfunction patients.Level of evidenceNA.

show abstract

“…Die Wichtigkeit des Riechens ist vielen durch die Pandemie erst bewusst geworden. Wer anderes als Thomas Hummel und Koautoren wären besser berufen, uns über den neuesten Stand zu Riechstörungen und deren Behandlung zu informieren [6]. Auch hier schauen wir über den Tellerrand: Ilona Croy und Antonie Bierling aus Jena führen uns in die Welt der Interaktion zwischen Riechen und Emotionen [7].…”

unclassified

Editorial

Guntinas‐Lichius¹

2023

Laryngorhinootologie

View full text Add to dashboard Cite

show abstract

Riechen und Riechstörungen

Cited by 4 publications

References 457 publications

The Molecular Basis of Olfactory Dysfunction in COVID-19 and Long COVID

The Molecular Basis of Olfactory Dysfunction in COVID-19 and Long COVID

Reliability and validity of the Arabic version of the brief version of the Questionnaire of Olfactory Disorders

Editorial

Contact Info

Product

Resources

About