Effect of sodium butyrate on performance, immune status, microarchitecture of small intestinal mucosa and lymphoid organs in broiler chickens

Sikandar, Arbab; Zaneb, Hafsa; Younus, Muhammad; Masood, Saima; Aslam, Asim; Khattak, Farina; Ashraf, Saima; Yousaf, Muhammad; Rehman, Habib

doi:10.5713/ajas.16.0824

Cited by 81 publications

(66 citation statements)

References 27 publications

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“…These variable results may be attributed to the available contents of the SB addition and the type of microbial environment to which the chicks were exposed, as described by Lesson et al [ 20 ] and Smulikowska et al [ 15 ], who detected unremarkable variance in growth performance of healthier broilers raised in an environment with fewer pathogenic bacteria. Moreover, in the present study, specially coated SB additions delivered the portion of butyrate in the further distal intestinal tract because of its slow release during digestion, which caused mucosal modulation in the gut [ 13 , 28 ]. A considerable quantity of butyric acid may therefore be preferentially applied by enterocytes to stimulate intestinal development and function in chicks rather than improve growth performance alone during the starter period.…”

Section: Discussionmentioning

confidence: 99%

Dietary sodium butyrate improves intestinal development and function by modulating the microbial community in broilers

Xiao

et al. 2018

PLoS ONE

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This study investigated the effects of dietary sodium butyrate (SB) supplementation, provided as a specially coated product, on growth performance, intestinal development, morphological structure and function in broilers. In total, 720 one-day-old Arbor Acres male broilers were randomly allocated into six treatment groups with six replicates each and then fed basal diets (control) supplemented with 0, 200, 400, 800 or 1000 mg/kg of SB or with antibiotics (100 mg/kg aureomycin and 20 mg/kg colistin sulfate). The growth trial lasted for 42 days. No differences (P>0.05) in growth performance were detected between groups during the grower period (1–21 d) or over the total (1–42 d) trial period, whereas the addition of SB improved the intestinal structure by stimulating (P<0.05) goblet cells on jejunal and ileal villi accompanied by a trend towards increased (Pdiets<0.10) ileal villus height. In addition, more inerratic leaf-shaped villi and mucus secretion and significantly fewer erosions were demonstrated by scanning electron microscopy. Apart from decreased (P<0.05) malondialdehyde (MDA) in the ileal mucosa at 21 d of age, supplemental SB at higher doses (800 mg/kg) led to greater (P<0.05) total antioxidant capacity and depressed (P<0.05) MDA concentrations in the jejunal mucosa. Birds fed with 400 mg/kg and 800 mg/kg SB had higher (P<0.05) acetic acid concentrations at 42 d and higher butyric acid at 21 d in the jejunum chyme. Morever, chicks fed SB diet were found to have higher concentrations of butyric acid (P<0.05) in the ileal chyme. SB additions at 400 mg/kg displayed higher Firmicutes and Proteobacteria levels, while a higher (P<0.05) relative abundance of Bacteroidetes was observed at 800 mg/kg. Furthermore, we found a striking decrease in Enterobacteriaceae and increases in Lachnospiraceae and Rikenellaceae in the cecal lumen of birds fed 800 mg/kg SB as well as a higher proportion of Ruminococcaceae and a noticeable reduction (P<0.05) of Lactobacillaceae in birds treated with 400 mg/kg SB. Taken together, our results support the importance of SB in improving the intestinal development, morphological structure and biological functions of broilers through modulation of the microbial community, which seems to be optimized for gut health at higher doses (800 mg/kg) of SB.

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Section: Discussionmentioning

confidence: 99%

Dietary sodium butyrate improves intestinal development and function by modulating the microbial community in broilers

Xiao

et al. 2018

PLoS ONE

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“…Prevalence of M. paratuberculosis in suspect Johne's disease dairy cattle by fecal culture was reported to be 50% in Egypt and 41% by culture or 32% by ELISA in Brazil (Salem et al, 2005;Ristow et al, 2007). Meta-analysis of results from buffalo suspected of Johne's disease in Pakistan and India were M. paratuberculosis positive in 12% of cases (95%CI 11-15, I 2 0%) by PCR, 5% (2-10, I 2 0%) by ELISA and 7% (0-27, I 2 99%) by visual confirmation (Sivakumar et al, 2006;Khan et al, 2010;Sikandar et al, 2012). Suspected Johne's disease in beef and dairy cattle from Europe and Asia were M. paratuberculosis positive in 16.8% of cases (10.9-23.7, I 2 91%) by PCR and culture (Branciari et al, 2008;Kaur et al, 2010;Khan et al, 2010;Munster et al, 2011).…”

Section: Paratuberculosis Infection In Animalsmentioning

confidence: 99%

Mycobacterium avium ssp . paratuberculosis detection in animals, food, water and other sources or vehicles of human exposure: A scoping review of the existing evidence

Waddell

Rajić

Stärk

et al. 2016

Preventive Veterinary Medicine

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“…A presença de butirato no intestino exerce efeito anti-inflamatório na mucosa, redução de estresse oxidativo e de diarreias, incluindo ainda estimulo à expressão gênica e diferenciação celular (BEDFORD ; GONG, 2017), além de ser fonte energética de utilização rápida para enterócitos, aumentando a atividade mitótica nas criptas e proporcionando maiores vilosidades. Sikandar et al (2017) observaram aumento na altura de vilosidades intestinais de frangos de corte suplementados com butirato na dieta, concordando com os achados na presente pesquisa.…”

Section: Resultsunclassified

Taninos E Ácido Butírico Como Melhoradores De Desempenho Para Frangos De Corte

Petrolli¹,

Guarnieri²,

Facchi³

et al. 2019

Enci Bio

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The trial had aimed to assess the place of growth promoters by organic additives based on herbal extracts (Castanea sativa + Acacia mearnsii) and butyric acid on the growth performance, cost/Kg and histology of the intestinal mucosa of broiler chicks. It was conducted in West Santa Catarina State University, with 600 male Cobb chickens, distributed in a ramdomized design in five treatments, eight repetitions and fifteen animals each. Was evaluated a blend containing 60% of herbal extracts and 40% of sodium butyrate. The treatments were distributed in T1-positive control (30 ppm halquinol), T2-negative control (no additives), T3-negative control + 300 ppm of organic additives, T4-negative control + 600 ppm of organic additives, T5-negative control + 1200 ppm of organic additives. All birds were fed with anticoccidian (monensin + salinomycin) from 1 to 35 days old. The results showed improving (P<0.05) on live weight, weight gain, feed intake and feed conversion ratio in bird fed with de blends and halquinol, in comparison of broilers fed no additives, in 1 to 21 and 1 to 42 days of age. There were better production efficiency index (P<0.05) and cost/kg produced in birds fed all additives than birds fed no growth promoters. The compounds tested can replace the growth promoters in chicken production, without affecting the performance and intestinal quality.

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Effect of sodium butyrate on performance, immune status, microarchitecture of small intestinal mucosa and lymphoid organs in broiler chickens

Cited by 81 publications

References 27 publications

Dietary sodium butyrate improves intestinal development and function by modulating the microbial community in broilers

Dietary sodium butyrate improves intestinal development and function by modulating the microbial community in broilers

Mycobacterium avium ssp . paratuberculosis detection in animals, food, water and other sources or vehicles of human exposure: A scoping review of the existing evidence

Taninos E Ácido Butírico Como Melhoradores De Desempenho Para Frangos De Corte

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