Effect of Smoking and Gender on Pulmonary Function and Clinical Features in Sarcoidosis

Krell, Willane S.; Bourbonnais, Julie M.; Kapoor, Rajat; Samavati, Lobelia

doi:10.1007/s00408-012-9406-8

Cited by 11 publications

(5 citation statements)

References 25 publications

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“…Black Americans have a higher prevalence of extrathoracic involvement [30]. A recent study demonstrated that female smokers were more likely to have a reduced diffusion capacity for carbon monoxide than male smokers, and both female sex and smoking are associated with the development of extrapulmonary manifestations of the disease [64]. …”

Section: Differences In Prognosismentioning

confidence: 99%

Sarcoidosis: Sex-Dependent Variations in Presentation and Management

Birnbaum

Rifkin

2014

Journal of Ophthalmology

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Sarcoidosis is an inflammatory disease with a wide range of clinical presentations. The manifestations and prognosis in sarcoidosis are dependent upon not only organ involvement but also age and sex. The purpose of this review is to describe the systemic and ocular manifestations of sarcoidosis with a specific focus on sex-dependent difference in presentation and management. Sarcoidosis is more common in women, particularly in patients who present after age of 50 years. Women with sarcoidosis are more likely to develop cystoid macular edema and the mortality rate is higher than that of men.

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Section: Differences In Prognosismentioning

confidence: 99%

Sarcoidosis: Sex-Dependent Variations in Presentation and Management

Birnbaum

Rifkin

2014

Journal of Ophthalmology

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“…8 In a US study of 518 patients, smokers also were found to have a higher incidence of extrapulmonary involvement, compared with that of nonsmokers. 21 Our study has several limitations. First, we cannot exclude the possibility that the observation is because of residual confounding.…”

Section: Discussionmentioning

confidence: 91%

“… 8 In a US study of 518 patients, smokers also were found to have a higher incidence of extrapulmonary involvement, compared with that of nonsmokers. 21 …”

Section: Discussionmentioning

confidence: 99%

Negative Association of Smoking History With Clinically Manifest Cardiac Sarcoidosis: A Case-Control Study

Nery

Wiefels

et al. 2022

CJC Open

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“…Several previous studies suggest that smoking may be a protective factor against developing pulmonary sarcoidosis but may elevate the risk of extrapulmonary manifestations [ 23 , 24 ]. However, as is true of many presentations of sarcoidosis, geoepidemiological variations between populations are associated with diverse and varied manifestations.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and clinical outcomes of patients with Sarcoidosis admitted for ST-elevation myocardial infarction in the United States: A propensity matched analysis from the National Inpatient Sample

Ahmed,

Najam,

Ramphul

et al. 2024

Arch Med Sci Atheroscler Dis

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IntroductionSarcoidosis is a systemic inflammatory disorder characterised by non-caseating granulomas. Cardiac sarcoidosis (CS) normally causes conduction abnormalities, ventricular arrhythmias, and heart failure. Little is known about the characteristics and impact of sarcoidosis in patients admitted with ST-elevation myocardial infarction (STEMI). This study aims to fill this void.Material and methodsUtilising the National Inpatient Sample (NIS) database (2016–2020), individuals with STEMI were identified and categorised based on sarcoidosis presence whilst adjusting for confounders via logistic regression models.ResultsAmong 851,290 STEMI patients, 1215 had sarcoidosis. Before propensity matching, sarcoidosis patients were notably different in demographics and comorbidities compared to non-sarcoidosis patients. After propensity score matching (PSM), sarcoidosis patients were found to have a higher incidence of supraventricular tachycardia (SVT) (2.5% vs. 1.3%, p = 0.024) and acute kidney injury (AKI) (23.3% vs. 20.8%, aOR = 1.269, 95% CI: 1.02–1.58, p = 0.033) but a lower incidence of undergoing coronary artery bypass graft (CABG) (5.5% vs. 8.5%, aOR = 0.663; 95% CI: 0.472–0.931, p = 0.018), while no significant disparities were noted in PCI, cardiogenic shock, mortality, or mean length of stay (LOS).ConclusionsUsing propensity-matched large real-world data of STEMI patients, sarcoidosis was associated with fewer cases of CABG and a greater incidence of AKI and SVT compared to non-sarcoidosis patients.

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Effect of Smoking and Gender on Pulmonary Function and Clinical Features in Sarcoidosis

Abstract: Our data indicate that both cigarette smoking and gender are important in shaping the clinical manifestations of sarcoidosis. The nature of the gender difference requires further study and may be related to differences in inflammatory response.

Cited by 11 publications

References 25 publications

Sarcoidosis: Sex-Dependent Variations in Presentation and Management

Sarcoidosis: Sex-Dependent Variations in Presentation and Management

Negative Association of Smoking History With Clinically Manifest Cardiac Sarcoidosis: A Case-Control Study

Characteristics and clinical outcomes of patients with Sarcoidosis admitted for ST-elevation myocardial infarction in the United States: A propensity matched analysis from the National Inpatient Sample

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