Sarcoidosis: Sex-Dependent Variations in Presentation and Management

Birnbaum, Andrea D.; Rifkin, Lana M.

doi:10.1155/2014/236905

Cited by 35 publications

(37 citation statements)

References 57 publications

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“…Gender is important for many epidemiological and clinical characteristics, including sarcoidosis treatment options and prognosis [2]. Many autoimmune diseases are more common in females, and sarcoidosis is no exception [6].…”

Section: Discussionmentioning

confidence: 99%

“…Although ACE is not specific for sarcoidosis, it is used as a diagnostic and prognostic marker because its serum concentration is high in 60%-70% of patients depending on disease extent and activity [2,17]. Although some researchers report that there is no difference regarding ACE activities between sexes [2,18], one Turkish study reported there were more females and serum ACE levels were significantly lower among patients over 50 years of age with sarcoidosis [3]. We found a significant decrease in serum ACE values among patients ≥60 years.…”

Section: Discussionmentioning

confidence: 99%

“…It can occur in patients of both sexes and all age and ethnic groups [1][2][3][4]. However, the peak incidences are in adults between 20 and 39 years old, though in Scandinavian countries and Japan there is a second peak in females over 50 [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…However, the peak incidences are in adults between 20 and 39 years old, though in Scandinavian countries and Japan there is a second peak in females over 50 [1,2]. Females are more affected than males [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Age Distribution and Disease Presentation of 1269 Patients with Sarcoidosis

et al. 2017

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Objective: While the incidence of sarcoidosis peaks between 20 and 39 years, it is comparatively low in elderly subjects. We sought to determine whether there are age-dependent differences in the demographic and laboratory characteristics of patients with sarcoidosis. Materials and Methods: We retrospectively collected information from our database using the International Classification of Disease (ICD) diagnostic code D86 between 2008 and 2014. Patients were divided into three groups: 20-39 years old (Group 1), 40-59 years old (Group 2), and 60-80 years old (Group 3). Results: A total of 3988 patients with code of D86 were included in the study. After the exclusion of noneligible patients, the number of cases in Groups 1, 2, and 3 were 276, 641, and 352, respectively. The groups were compared according to demographic characteristics, ICD diagnostic codes, and laboratory parameters. The ratio of female patients was significantly higher in Group 3 than in Groups 1 and 2 (p=0.000). There was no difference in diagnostic codes of the ICD subgroups between groups (p=0.19). While the level of bloodurea nitrogen was significantly higher in Group 3 patients than in other groups (p=0.000), serum angiotensinconverting enzyme (ACE) values were found to be significantly low in Group 3 (p=0.010). The mean ACE values did not differ between females and males (50.8±39.3 and 59.1±45.5 mg/dL, respectively) (p=0.18). Conclusion:The majority of patients with sarcoidosis were female in all age groups and pulmonary sarcoidosis was the most common presentation of the disease. Elderly patients (≥60 years) with sarcoidosis had lower serum ACE levels than younger patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analysis of Age Distribution and Disease Presentation of 1269 Patients with Sarcoidosis

et al. 2017

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“…Thus hormonal therapy may be considered as a possible therapeutic adjunct for sarcoidosis patients. 162, 163 …”

Section: Discussionmentioning

confidence: 99%

The Role of Sex in Uveitis and Ocular Inflammation

Yeung¹,

Popp²,

Chan³

2015

International Ophthalmology Clinics

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Uveitides can be due to non-infectious and infectious etiologies. It has been observed that there is a gender difference with a greater preponderance of non-infectious uveitis in women than in men. This review will describe both non-infectious and infectious uveitides and describes some of the current autoimmune mechanisms thought to be underlying the gender difference. It will specifically look at non-infectious uveitides with systemic involvement including juvenile idiopathic arthritis, spondyloarthopathies, sarcoidosis, Behçet’s disease, and Vogt-Koyanagi-Harada disease and at uveitides without systemic involvement including sympathetic ophthalmia, birdshot chorioretinitis, and the white dot syndromes. Infectious uveitides like acute retinal necrosis, progressive outer retinal necrosis, and cytomegalovirus mediated uveitis will be mentioned. Different uveitides with female- or male- predominance are presented and discussed.

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