Effect of Small Dose of Mannooligosaccharides from Coffee Mannan on Defecating Conditions and Fecal Microflora

Umemura, Masao; Fujii, Shigeyoshi; Asano, Ichiro; Hoshino, Hiromitsu; Iino, Hisakazu

doi:10.3136/fstr.10.174

Cited by 10 publications

(5 citation statements)

References 12 publications

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“…Moreover, the percentage of subjects whose stool IgA value increased was higher in the 3CMH group than in the placebo and 5CMH groups. This result was consistent with other studies reporting that daily consumption of MOS at 1–3 g was more effective on the gut microbiome and immune modification than a higher dosage ( Asano et al, 2004 ; Kumao et al, 2006 ; Umemura et al, 2004a ; Umemura et al, 2004b ; Walton et al, 2010 ).…”

Section: Discussionsupporting

confidence: 92%

A randomized trial to evaluate the impact of copra meal hydrolysate on gastrointestinal symptoms and gut microbiome

Sathitkowitchai

Suratannon

Keawsompong

et al. 2021

PeerJ

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The impact of copra meal hydrolysate (CMH) on gut health was assessed by conducting a double-blinded, placebo-controlled study. Sixty healthy adult participants, aged 18–40 years were assigned to daily consume 3 g of CMH, 5 g of CMH or placebo in the form of drink powder for 21 days. Consumption of CMH at 3 g/d improved defecating conditions by reducing stool size and also relieved flatulence and bloating symptoms. Fecal samples were collected serially at the baseline before treatment, after the treatment and after a 2-week washout period. The gut microbiomes were similar among the treatment groups, with microbial community changes observed within the groups. Intake of CMH at 3 g/d led to increase microbial diversity and richness. Reduction of the ratio between Firmicutes to Bacteroidetes was observed, although it was not significantly different between the groups. The 3 g/d CMH treatment increased beneficial microbes in the group of fiber-degrading bacteria, especially human colonic Bacteroidetes, while induction of Bifidobacteriaceae was observed after the washout period. Intake of CMH led to increase lactic acid production, while 3 g/d supplement promoted the present of immunoglobulin A (IgA) in stool samples. The 3 g daily dose of CMH led to the potentially beneficial effects on gut health for healthy individuals.

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Section: Discussionsupporting

confidence: 92%

A randomized trial to evaluate the impact of copra meal hydrolysate on gastrointestinal symptoms and gut microbiome

Sathitkowitchai

Suratannon

Keawsompong

et al. 2021

PeerJ

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“…Glucomannans, isolated from konjac mannan, have been used in Asia for centuries as a thickening agent (24). Because mammals do not possess the enzymes necessary to cleave the β‐1,4‐linked sugar residues of the mannan backbone, these polymers are believed to pass through the upper gastrointestinal tract undigested and encounter some amount of hydrolysis and uptake by bacteria in the colon, where mannan and MOS are proposed to selectively enhance the bifidobacteria species (25,26,27,28,29,30). Glucomannan supplementation promotes weight loss in overweight and obese individuals, purportedly through the fiber‐fill effect and reduced fat uptake through the gastrointestinal tract (31).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Mannan Oligosaccharide Supplementation on Body Weight Gain and Fat Accrual in C57Bl/6J Mice

Smith

Nagy

Wilson

et al. 2010

Obesity

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The prevalence of obesity in industrialized societies has become markedly elevated. In contrast, model organism research shows that reducing caloric intake below ad libitum levels provides many health and longevity benefits. Despite these benefits, few people are willing and able to reduce caloric intake over prolonged periods. Prior research suggests that mannooligosaccharide (MOS or mannan) supplementation can increase lifespan of some livestock and in rodents can reduce visceral fat without reducing caloric intake. Hence, we tested the effect of MOS supplementation as a possible calorie restriction (CR) mimetic (CRM) in mice. C57Bl/6J male mice were fed a high‐fat “western” type diet with or without 1% MOS (by weight) supplementation (n = 24/group) from 8 to 20 weeks of age. Animals were housed individually and provided 95% of ad libitum food intake throughout the study. Body weight was measured weekly and body composition (lean and fat mass) measured noninvasively every 3 weeks. Individual fat depot weights were acquired by dissection at study completion. Supplementation of a high‐fat diet with 1% MOS tended to reduce total food intake (mean ± s.d.; control (CON): 293.69 ± 10.53 g, MOS: 288.10 ± 11.82 g; P = 0.09) during the study. Moreover, MOS supplementation had no significant effect on final body weight (CON: 25.21 ± 2.31 g, MOS: 25.28 ± 1.49 g; P = 0.91), total fat (CON: 4.72 ± 0.90 g, MOS: 4.82 ± 0.83 g; P = 0.69), or visceral fat (CON: 1.048 ± 0.276 g, MOS: 1.004 ± 0.247 g; P = 0.57). Contrary to previous research, MOS supplementation had no discernable effect on body weight gain or composition during this 12‐week study, challenging the potential use of MOS as a CRM or body composition enhancer.

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“…Umemura et al reported that the intake of MOS also increases the volume of feces. 15) Therefore, it is possible that not only the level of fecal fat but also the volume of fat excreted are likely to increase as the result of the intake of MOS. To prove this, clinical tests with a focus on details of fat input and output balance will be necessary.…”

Section: Fig 2 Effect Of Milk Based Liquid Coffee Containing Mos Onmentioning

confidence: 99%

Mannooligosaccharides Blended Coffee Beverage Intake Increases the Fat Level in Feces

Kumao

Fujii

2006

JOURNAL OF HEALTH SCIENCE

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Liquid coffee and milk based liquid coffee, both containing 1.0 g of mannooligosaccharides (MOS) from coffee mannan, were administered to two groups of six subjects each. The subjects consumed one or the other of the beverage everyday for two weeks. The level of fat in their excrement was subsequently analyzed. In both liquid coffee (p < 0.05, respectively) and milk based liquid coffee (p < 0.05, respectively), the concentration of the beverage containing MOS intake showed a significant decrease in comparison with the placebo and interval or those who did not drink any coffee. The result suggests that the intake of MOS can increase the level of fat excreted from the body irrespective.

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Effect of Small Dose of Mannooligosaccharides from Coffee Mannan on Defecating Conditions and Fecal Microflora

Cited by 10 publications

References 12 publications

A randomized trial to evaluate the impact of copra meal hydrolysate on gastrointestinal symptoms and gut microbiome

A randomized trial to evaluate the impact of copra meal hydrolysate on gastrointestinal symptoms and gut microbiome

The Effect of Mannan Oligosaccharide Supplementation on Body Weight Gain and Fat Accrual in C57Bl/6J Mice

Mannooligosaccharides Blended Coffee Beverage Intake Increases the Fat Level in Feces

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