Effect of sintering temperature rise from 870 to 920 °C on physicomechanical and biological quality of nano-hydroxyapatite: An explorative multi-phase experimental in vitro/vivo study

Khoshzaban, Ahad; Rakhshan, Vahid; Najafi, Farhood; Aghajanpour, Leila; Hashemian, Seyed Jafar; Keshel, Saeed Heidari; Watanabe, Ikuya; Valanezhad, Alireza; Kashi, Tahereh Sadat Jafarzadeh

doi:10.1016/j.msec.2017.03.183

Cited by 11 publications

(4 citation statements)

References 31 publications

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“…Non-calcinated Mg-doped nanoHAP showed an initial burst release of Mg 2+ ions, followed by a noticeable decline. These data are consistent with those presented by Khoshzaban et al 57 and Sprio 58 , this phenomenon could be related to the release of loosely bonded ions, resulting in faster ion loss rates at the initial stages of incubation 17 , 18 .…”

Section: Discussionsupporting

confidence: 92%

Calcination and ion substitution improve physicochemical and biological properties of nanohydroxyapatite for bone tissue engineering applications

Kurzyk,

Szwed-Georgiou,

Pagacz

et al. 2023

Sci Rep

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Nanohydroxyapatite (nanoHAP) is widely used in bone regeneration, but there is a need to enhance its properties to provide stimuli for cell commitment and osteoconduction. This study examines the effect of calcination at 1200 °C on the physicochemical and biological properties of nanoHAP doped with magnesium (Mg2+), strontium (Sr2+), and zinc (Zn2+). A synergistic effect of dual modification on nanoHAP biological properties was investigated. The materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), BET analysis, Fourier-transform spectroscopy, and thermal analysis methods. Furthermore, ion release tests and in vitro biological characterization, including cytocompatibility, reactive oxygen species production, osteoconductive potential and cell proliferation, were performed. The XRD results indicate that the ion substitution of nanoHAP has no effect on the apatite structure, and after calcination, β-tricalcium phosphate (β-TCP) is formed as an additional phase. SEM analysis showed that calcination induces the agglomeration of particles and changes in surface morphology. A decrease in the specific surface area and in the ion release rate was observed. Combining calcination and nanoHAP ion modification is beneficial for cell proliferation and osteoblast response and provide additional stimuli for cell commitment in bone regeneration.

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Section: Discussionsupporting

confidence: 92%

Calcination and ion substitution improve physicochemical and biological properties of nanohydroxyapatite for bone tissue engineering applications

Kurzyk,

Szwed-Georgiou,

Pagacz

et al. 2023

Sci Rep

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show abstract

“…Noncalcinated material showed an initial burst release of Mg 2+ ions, followed by a noticeable decline. These results are consistent with the data presented by Khoshzaban et al [57] and Sprio [58], and this phenomenon could be related to the release of loosely bonded ions, resulting in faster ion loss rates at the initial stages of incubation [17,18].While analyzing ion release pro les from strontium-and magnesium-modi ed nanoHAPs, we noticed that the release rates of Sr 2+ were signi cantly slower than those of Mg 2+ . This may be due to much stronger Sr 2+ than Mg 2+ bonding to the nanoHAP structure [59].…”

Section: Discussionsupporting

confidence: 91%

Effect of calcination on physicochemical and biological properties of ion-modified nanohydroxyapatite for bone tissue engineering applications

Kurzyk

Szwed-Georgiou

Pagacz

et al. 2023

Preprint

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The study examines the effect of calcination at a temperature of 1200°C on the physicochemical and biological properties of nanohydroxyapatite (nanoHAP) substituted with magnesium (Mg2+), strontium (Sr2+), and zinc (Zn2+). The materials were characterized by Fourier-transform spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and thermal analysis methods. Moreover, in vitro biological characterization, including cytocompatibility, cell proliferation, osteogenic potential, and reactive oxygen species production, was performed. The XRD results indicate that the ion substitution of nanoHAP has no effect on the apatite structure, and after calcination, β-tricalcium phosphate (β-TCP) is formed as an additional phase. SEM analysis showed that calcination induces the agglomeration of particles and changes in surface morphology. A decrease in the specific surface area and in the ion release rate was observed. Calcination and nanoHAP ion modification are beneficial for cell proliferation and osteoblast response and provide additional stimuli for cell commitment necessary for bone regeneration.

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“…It has been proclaimed that ideal properties for calcium phosphates (including HA) could be gained by rising the sintering temperature to about 1300 °C. Another study done by Kamalanathan et al [9] showed that the temperature for the sintering could be in the range of 800 °C to 1400 °C. On the contrary, the effect of sintering temperatures at lower than 1000 °C was not often assessed [10].…”

Section: Introductionmentioning

confidence: 99%

Sinterability of Magnesium Hydroxyapatite Bioceramic and Its Mechanical Properties

Ramli

Murad

Masdek

2018

IJET

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One of the most favoured material in bone tissue engineering field nowadays is hydroxyapatite (HA), which is also known to be bioactive and has a similar composition to human bone. However, developing an artificial bone or bone graft using biocompatible HA is a challenging task due to the lower strength of the main substance. To improve the mechanical properties of synthetic HA, introduction of metallic substance such as magnesium (Mg) into HA has been proposed. In this present study, 0, 10 15 wt% of magnesium hydroxyapatite (MgHA) nanopowders were prepared by a simple wet precipitation method. These nanopowders were then compacted using a 10-ton compression uniaxial press machine with 150 MPa pressure to form a disc shape of dense MgHA. After that, the MgHA discs were sintered at a temperature of 1000 °C and 1100 °C to remove the organic compounds and further densify the ceramics. XRD results showed that the crystallinity of MgHA increased when the sintering temperature increases. The compression test showed that the 10 wt% MgHA sample recorded the highest compressive strength (243.59 MPa) when sintered at 1100 °C, while pure HA has the lowest value with 49.37 MPa. This study also demonstrates that sintering temperature at 1100 °C gives significant improvement to the mechanical properties of the MgHA dense bodies compared to sintering at 1000 °C.

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Effect of sintering temperature rise from 870 to 920 °C on physicomechanical and biological quality of nano-hydroxyapatite: An explorative multi-phase experimental in vitro/vivo study

Cited by 11 publications

References 31 publications

Calcination and ion substitution improve physicochemical and biological properties of nanohydroxyapatite for bone tissue engineering applications

Calcination and ion substitution improve physicochemical and biological properties of nanohydroxyapatite for bone tissue engineering applications

Effect of calcination on physicochemical and biological properties of ion-modified nanohydroxyapatite for bone tissue engineering applications

Sinterability of Magnesium Hydroxyapatite Bioceramic and Its Mechanical Properties

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