Statement of the problem: Ceramics and glass-ceramics are materials of choice for dental crowns due to their attractive hardness, biocompatibility, etc. However, a major problem with their usage is the observed high wear of either the opposing dental enamel or both the enamel and ceramic itself. Objective: The present study aimed at ranking and comparing the wear performance of three different ceramic systems as an indication of wear. In addition, change in surface roughness was calculated using optical surface profiler. Results: The statistically significant highest mean material's weight loss was recorded in porcelain group, whereas the statistically significant lowest mean weight loss was recorded in BruxZir group. The statistically significant greatest mean antagonist weight loss was recorded for e.max antagonist cusp, whereas the statistically significant lowest mean weight loss was recorded for BruxZir antagonist cusp.Surface roughness increased after wear procedure in all samples. Conclusions: Within the limitations of this in vitro study, monolithic zirconia and porcelain resulted in less wear depth to human enamel compared to lithium disilicate based ceramics (e.max CAD). However, porcelain is more affected by wear compared to zirconia.