Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model

Vargas-Mendoza, Nancy; Ángeles-Valencia, Marcelo; Morales-González, Ángel; Morales-Martínez, Mauricio; Madrigal-Santillán, Eduardo; Álvarez-González, Isela; Fregoso-Aguilar, Tomás; Delgado-Olivares, Luis; Morales-González, José A

doi:10.3390/jfmk6030072

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…In addition, SM was indicated to improve muscle recovery and to ameliorate inflammation and damaged tissue in rats subjected to regular exercise training [128]. Finally, a reduction in lung tissue inflammation was evident in rats subjected to 8-week exercise training due to the administration of SM (100 mg [129]). In elderly rats with HFD-induced liver injury, the combination of SM and vitamin C dietary supplementation with exercise was shown to effectively reduce oxidative stress and liver inflammation [130].…”

Section: Ageing and Exercising Modelsmentioning

confidence: 97%

Silymarin and Inflammation: Food for Thoughts

Surai,

Earle-Payne

2024

Antioxidants

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Inflammation is a vital defense mechanism, creating hostile conditions for pathogens, preventing the spread of tissue infection and repairing damaged tissues in humans and animals. However, when inflammation resolution is delayed or compromised as a result of its misregulation, the process proceeds from the acute phase to chronic inflammation, leading to the development of various chronic illnesses. It is proven that redox balance disturbances and oxidative stress are among major factors inducing NF-κB and leading to over-inflammation. Therefore, the anti-inflammatory properties of various natural antioxidants have been widely tested in various in vitro and in vivo systems. Accumulating evidence indicates that silymarin (SM) and its main constituent silibinin/silybin (SB) have great potential as an anti-inflammation agent. The main anti-inflammatory mechanism of SM/SB action is attributed to the inhibition of TLR4/NF-κB-mediated signaling pathways and the downregulated expression of pro-inflammatory mediators, including TNF-α, IL-1β, IL-6, IL-12, IL-23, CCL4, CXCL10, etc. Of note, in the same model systems, SM/SB was able to upregulate anti-inflammatory cytokines (IL-4, IL-10, IL-13, TGF-β, etc.) and lipid mediators involved in the resolution of inflammation. The inflammatory properties of SM/SB were clearly demonstrated in model systems based on immune (macrophages and monocytes) and non-immune (epithelial, skin, bone, connective tissue and cancer) cells. At the same time, the anti-inflammatory action of SM/SB was confirmed in a number of in vivo models, including toxicity models, nonalcoholic fatty liver disease, ischemia/reperfusion models, stress-induced injuries, ageing and exercising models, wound healing and many other relevant model systems. It seems likely that the anti-inflammatory activities of SM/SB are key elements on the health-promoting properties of these phytochemicals.

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Section: Ageing and Exercising Modelsmentioning

confidence: 97%

Silymarin and Inflammation: Food for Thoughts

Surai,

Earle-Payne

2024

Antioxidants

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Comparative efficacy of silibinin and nano-silibinin on lead poisoning in Male Wistar rats

Mohammadi¹,

Ariafar²,

Talebi-Ghane³

et al. 2022

Toxicology

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Silymarin as an Antioxidant Therapy in Chronic Liver Diseases: A Comprehensive Review

Dhande,

Dhok,

Anjankar

et al. 2024

Cureus

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Chronic liver diseases (CLDs) such as chronic hepatitis, cirrhosis, and non-alcoholic fatty liver disease (NAFLD) present significant global health challenges due to their high morbidity and mortality rates. Silymarin, a flavonoid complex derived from the seeds of the milk thistle plant (Silybum marianum), has been extensively studied for its hepatoprotective properties. This review aims to evaluate the role of silymarin as an antioxidant therapy in managing CLDs. We explore its efficacy, safety, and mechanisms of action through a comprehensive analysis of clinical trials and scientific studies. Silymarin offers protective effects on the liver and shows promise in improving liver function and histological outcomes in various chronic liver conditions. Despite the promising results, further research is needed to fully elucidate the optimal dosing regimens, long-term safety, and potential drug interactions of silymarin. This review underscores the therapeutic potential of silymarin in CLDs and provides a foundation for future studies aimed at enhancing its clinical application.

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Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model

Cited by 3 publications

References 56 publications

Silymarin and Inflammation: Food for Thoughts

Silymarin and Inflammation: Food for Thoughts

Comparative efficacy of silibinin and nano-silibinin on lead poisoning in Male Wistar rats

Silymarin as an Antioxidant Therapy in Chronic Liver Diseases: A Comprehensive Review

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