Comparative efficacy of silibinin and nano-silibinin on lead poisoning in Male Wistar rats

Mohammadi, Mojdeh; Ariafar, Saba; Talebi-Ghane, Elaheh; Afzali, Saeed

doi:10.1016/j.tox.2022.153242

Cited by 10 publications

(6 citation statements)

References 62 publications

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“…Our results revealed that Pb-induced acute nephrotoxicity is associated with body weight loss, which is in accordance with other studies (Ibrahim et al 2012;Mohammadi et al 2022). At this line, Aqeel et al, reported that lead acetate administration signi cantly decreased rat's body weight and increased kidney weigh, which is correlated with our ndings (Aqeel et al 2021).…”

Section: Discussionsupporting

confidence: 93%

“…However, silibinin and more-effectively Sili-NLCs signi cantly enhanced the antioxidant activities of SOD, CAT and GPx in a dose-dependent manner. According to our previous study, it has been reported that silibinin-loaded NLCs could markedly improve the levels of antioxidant content after Pb-induced hepatotoxicity (Mohammadi et al 2022). Also, Rezaee-Tazangi et al reported that silymarin-loaded poly lactic-co-glycolic acid nanoparticles is superior to the free silymarin for enhancing the levels of SOD, CAT, GSH, and GPx activity (Rezaee-Tazangi et al 2020).…”

Section: Discussionmentioning

confidence: 90%

“…It is proposed that after oral administration, silibinin rapidly absorbed by stomach and its bioavailability increased in the gastrointestinal tract by encapsulating into NLCs (Wu et al 2006;Abd El-Ghany 2022). On the other hand, Mohammadi et al reported that silibinin and especially nanosilibinin could effectively acts as chelating agent by reducing the blood Pb levels in rats (Mohammadi et al 2022). Therefore, it can be concluded that Pb absorption and its accumulation in the kidney decreased and its excretion from the body increased (Nolan and Shaikh 1992).…”

Section: Discussionmentioning

confidence: 99%

“…Clinical applications of silymarin are well known to contribute to its hepatoprotective effects for various kinds of liver diseases (e.g., toxic hepatitis, fatty liver, cirrhosis) (Scott Luper 1998) because of antioxidants, anti-in ammatory, free radical scavenging, and non-toxicity (LD50 = 385-920 mg/kg in rats) characteristics (Haddad et al 2011). In addition, the chelating properties of silibinin have also been proven (Muthumani and Prabu 2012;Mohammadi et al 2022). Although silibinin is associated with a lot of bene ts, low aqueoussolubility, low bioavailability (0.95%) due to phases I and II of biotransformation in the liver, and limited intestinal absorption are making its application restricted to long-term oral administration (Javed et al 2011;Betsou et al 2021).…”

Section: Introductionmentioning

confidence: 99%

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Potential protective effect of Silibinin-loaded nanostructured lipid carriers (NLCs) in lead-induced acute nephrotoxicity

Makhdoomi

Ariafar

Sanemar

et al. 2022

Preprint

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As a toxic heavy metal, lead (Pb) is well known for impairment of renal function due to oxidative injuries. Given the role of silibinin antioxidant activity, the present study investigated the effectiveness of silibinin-loaded nanostructured lipid carriers (Sili-NLCs) against Pb-induced acute nephrotoxicity in rats. The emulsification-solvent evaporation method applied to prepare Sili-NLCs. Sixty male Wistar rats were divided into ten separate groups. Animals were treated with Pb (50 mg/kg/day, i.p.) and with the same concentration of silibinin and Sili-NLCs (25, 50, and 100 mg/kg/day, p.o.) for six days. After sacrificing rats, kidney tissue samples were collected from all animals to assess the oxidative stress parameters. Also, histopathological examination using Hematoxylin-Eosin (H&E) studied. Our data revealed that Pb-induced oxidative damage which indicated by increasing lipid peroxidation (LPO) and nitric oxide (NO) accompanied by decreasing the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activity. Moreover, the histopathological examination correlated well with these findings. However, silibinin and especially Sili-NLCs significantly prevented the induction of oxidative damage. Nevertheless, our data suggested that Sili-NLCs are potentially superior to pure silibinin for attenuating Pb-induced acute nephrotoxicity. So, using novel therapeutic approaches is highly required.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Potential protective effect of Silibinin-loaded nanostructured lipid carriers (NLCs) in lead-induced acute nephrotoxicity

Makhdoomi

Ariafar

Sanemar

et al. 2022

Preprint

Self Cite

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“…Johnsen's mean testicular biopsy score count H and E 40x: Johnsen's mean testicular biopsy score (Table 1) was used to evaluate testicular histological damage and spermatogenesis with light microscopy [36,37] . Each testis's 30 tubules were given a grade.…”

Section: Histological and Immunohistochemical Studymentioning

confidence: 99%

Physiological and Histological Study of the Therapeutic Effect of Silibinin on Testicular Alteration in Adult Male Albino Rats

Melebary¹

2023

IJPS

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The male reproductive system is vulnerable to oxidative stress, which is linked to several disorders. Silibinin, a natural polyphenolic flavonoid, possesses antioxidant, anti-inflammation and anticancer properties. Considering silibinin's wide range of biological and metabolic roles (silibinin) plays, the current study was conducted to evaluate the biochemical, histological, immunohistochemical and morphometric changes that may develop in the rat testis exposed to oxidative stress and the possible protective role of silibinin. Thirty adult rats were used in the current study. Rats were equally divided into three groups. G1 negative control group, G2 was given thioacetamide (200 mg/kg body weight, G3 received silibinin at (100 mg/kg body weight) for 4 w concurrently with thioacetamide. Serum levels of sexual hormones and testicular oxidative stress markers were measured. Testicular sections were stained with haematoxylin and eosin, and immunohistochemical stains for Vimentin and p53 subjected to morphometric and statistical analysis. Testicular histological architecture and biochemical and morphometric markers all declined in the thioacetamide group. When rats were given silibinin, however, the normal biochemical and morphometric parameters were restored and the histological structure of their testicles was preserved. This investigation showed that silibinin might increase testosterone and gonadotropin levels and enhance several testicular indices (luteinizing hormone and follicle-stimulating hormone). The protective effects of silibinin on reproductive toxicity and oxidative stress were evidenced by the antioxidant activities and improvement of the histological structures of both Leydig and Sertoli cells. As a result, it can be used as a supplement to improve male reproductive function, particularly spermatogenesis.

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Silibinin-loaded Nanostructured Lipid Carriers (NLCs) Ameliorated Lead-induced Acute Nephrotoxicity in Male Rats

Makhdoomi,

Ariafar,

Mirzaei

et al. 2024

Cell Biochem Biophys

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Comparative efficacy of silibinin and nano-silibinin on lead poisoning in Male Wistar rats

Cited by 10 publications

References 62 publications

Potential protective effect of Silibinin-loaded nanostructured lipid carriers (NLCs) in lead-induced acute nephrotoxicity

Potential protective effect of Silibinin-loaded nanostructured lipid carriers (NLCs) in lead-induced acute nephrotoxicity

Physiological and Histological Study of the Therapeutic Effect of Silibinin on Testicular Alteration in Adult Male Albino Rats

Silibinin-loaded Nanostructured Lipid Carriers (NLCs) Ameliorated Lead-induced Acute Nephrotoxicity in Male Rats

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