Silymarin and Inflammation: Food for Thoughts

Surai, Peter F.; Surai, Anton; Earle-Payne, Katie

doi:10.3390/antiox13010098

Cited by 2 publications

(2 citation statements)

References 219 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Silymarin has good effects in terms of anticancer activity, regulation of apoptosis and inflammatory response [ 12 , 13 , 14 ], and protection and repair of liver damage [ 15 , 16 ]. It also significantly attenuates macroscopic colonic damage as well as reduces colonic myeloperoxidase activity.…”

Section: Introductionmentioning

confidence: 99%

Effects of Six Natural Compounds and Their Derivatives on the Control of Coccidiosis in Chickens

Hou,

Han,

Lin

et al. 2024

Microorganisms

View full text Add to dashboard Cite

Chicken coccidiosis costs the poultry industry over GBP 10 billion per year. The main method of preventing and controlling coccidiosis in chickens continues to be the use of drugs. Unfortunately, the prevalence of drug resistance in the field reduces or even eliminates the effectiveness of drugs, and drug residues in the food supply chain can also can be harmful to humans. Therefore, safe and effective anticoccidial drugs are urgently needed. Natural products have many advantages such as being safe, effective and inexpensive and are a sustainable way to control coccidiosis. In this study, the anticoccidial effects of six natural compounds were tested by Eimeria tenella infection. Oocyst production, cecum lesion, body weight gain, feed conversion ratio, and intestinal microbiota were measured. The results showed that nerolidol had a moderate effect on maintaining both body weight gain and feed conversion ratio. Silymarin and dihydroartemisinin showed significant anticoccidial effects by reducing total oocyst output. Dihydroartemisinin also significantly reduced the cecum lesion caused by Eimeria infection, but this compound may be toxic to the host at such informed doses because it decreases growth and survival rates. In addition, both silymarin and dihydroartemisinin partly restored the microbiota after challenge. This indicates that silymarin, dihydroartemisinin, and nerolidol are effective in the control of chicken coccidiosis. Our data provide basic knowledge about the anticoccidial effects of such natural compounds/derivates.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of Six Natural Compounds and Their Derivatives on the Control of Coccidiosis in Chickens

Hou,

Han,

Lin

et al. 2024

Microorganisms

View full text Add to dashboard Cite

show abstract

“…When the blood flow returns to ischemic liver, free oxygen radicals are formed as a result of some biochemical reactions. In this process, more damage occurs due to deterioration of antioxidant mechanisms [4,5].…”

Section: Introductionmentioning

confidence: 99%

The Promising Effects of Erdosteine and Vitamin B in the Liver Ischemia/Reperfusion Model in Anesthetized Rats

Eygi,

Gul,

Aslan

et al. 2024

Medicina

View full text Add to dashboard Cite

Background and Objectives: Erdosteine (Erd) is an antioxidant and anti-inflammatory drug. Vitamin B has been reported to exert anti-inflammatory and antioxidant effects. In this study, we investigated the effect of erdosteine and vitamin B complex on a liver ischemia/reperfusion (I/R) model. Materials and Methods: Thirty-two Wistar Albino male rats weighing 350–400 g were used. The animals were randomly selected and divided into four groups. The groups are as follows: first group (Sham), second group (I/R), third group (I/R + vit B), and fourth group (I/R + vit B + Erd). Rats were subjected to 45 min of hepatic ischemia, followed by a 45 min reperfusion period in the I/R and Vitamin B + Erd groups. An amount of 150 mg/kg/day of erdosteine was given orally for 2 days, and 0.05 mL/kg of i.p. vitamin B complex was given 30 min before the reperfusion. Serum biochemical parameters were measured. Serum Total Antioxidant Status (TAS) and Total Oxidant Status (TOS) were measured, and the Oxidative Stress Index (OSI) was calculated. Hepatic tissue samples were taken for the evaluation of histopathological features. Results: In terms of all histopathological parameters, there were significant differences in the I/R + vit B group and I/R + vit B + Erd group compared with the I/R group (p < 0.01). In terms of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), TNF-alpha, and IL-6 levels, there were significant differences between the I/R group and treatment groups (p < 0.01). The lowest TOS and OSI levels were obtained in the treatment groups, and these groups had statistically significantly higher TAS levels compared with the sham and I/R groups (p < 0.01). Conclusions: As a preliminary experimental study, our study suggests that these agents may have potential diagnostic and therapeutic implications for both ischemic conditions and liver-related diseases. These results suggest that the combination of vit B + Erd may be used to protect against the devastating effects of I/R injury. Our study needs to be confirmed by clinical studies with large participation.

show abstract

Silymarin and Inflammation: Food for Thoughts

Cited by 2 publications

References 219 publications

Effects of Six Natural Compounds and Their Derivatives on the Control of Coccidiosis in Chickens

Effects of Six Natural Compounds and Their Derivatives on the Control of Coccidiosis in Chickens

The Promising Effects of Erdosteine and Vitamin B in the Liver Ischemia/Reperfusion Model in Anesthetized Rats

Contact Info

Product

Resources

About