Effect of sex on recovery of ejection fraction in patients with anterior ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Guo, R. S.; Yang, Lixia; Liu, Bei; Qi, Feng; Wang, Xianmei; Guo, Chuan-ming; Zhang, Wei

doi:10.1097/mca.0000000000000060

Cited by 7 publications

(6 citation statements)

References 23 publications

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“…This effect on LVEF can be explained on the basis of our study in conjunction with another study which considered patients with anterior wall myocardial infarction (STEMI) only. 4 Multiple factors may be responsible for such results, which include older age at the time of presentation and more comorbidities at the time of presentation in women. The importance of such factors can be supported by various other studies.…”

Section: Discussionmentioning

confidence: 99%

“…The importance of such factors can be supported by various other studies. 4,13,14 Women were of older age as compared to men. Based on established facts, the cardio-protective effect of estrogen is responsible for the delay in the onset of cardiovascular disease in women, which translates into the fact that CAD would present at an older age in women.…”

Section: Discussionmentioning

confidence: 99%

“…Dokazano je da je oslabljena sistolička funkcija LV povezana s lošim ishodima, pa se ejekcijska frakcija lijeve klijetke (EF) smatra važnim čimbenikom za kratkoročne i dugoročne ishode. [4][5][6][7][8] Trenutačno je optimalna strategija liječenja bolesnika s MI-jem revaskularizacija zahvaćene žile s pomoću PCI-ja. 9,10 Usprkos dobro potvrđenoj ulozi PCI-ja u zaštiti vijabilnog tkiva miokarda i u poboljšanju opće funkcije LV-a, istraživanja su zabilježila različite ishode ovisno spolu.…”

Section: Methodsunclassified

“…Ovakav učinak na EF može se objasniti na temelju našeg istraživanja zajedno s rezultatima još jedne studije koja je uključivala bolesnike sa STEMI-jem koji je zahvatio prednju stijenku. 4 Više čimbenika može biti odgovorno za ovakve rezultate, uključujući stariju dob u trenutku primitka u bolnicu te viši pobol pri nastupu bolesti u žena. Važnost takvih čimbenika može se potkrijepiti raznim drugim istraživanjima.…”

Section: Raspravaunclassified

“…Impaired LV systolic function has been proven to be associated with poor outcomes, so left ventricular ejection fraction (LVEF) is regarded as an important factor for short and long-term outcomes. [4][5][6][7][8] Currently, the optimum strategy in treatment of patients with MI is revascularization of the culprit vessel with PCI. 9, 10 In spite of the well-established role of PCI in protecting viable myocardium and improvement in the overall LV function, variable outcomes have been reported based on gender differences.…”

mentioning

confidence: 99%

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The Relationship Between Gender and Ejection Fraction in Patients with Acute Coronary Syndrome after Reperfusion Therapy

Altaf¹,

Shah²

2019

Cardiologia Croatica

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Infarkt miokarda (MI) jedan je od glavnih uzroka smrti i pobola u cijelome svijetu, a perkutana koronarna intervencija (PCI) ima ključnu ulogu SAŽETAK: Uvod: Prethodna istraživanja o povezanosti spola i ejekcijske frakcije (EF) odnosila su se samo na jednožilnu koronarnu bolest te su uzimala u obzir samo bolesnike s akutnim infarktom miokarda s elevacijom ST-segmenta (STEMI). U ovom smo radu istražili učinak spola na EF u akutnome koronarnom sindromu, uključujući STEMI i akutni infarkt miokarda bez elevacije ST-segmenta (NSTEMI) kod koronarne bolesti svih krvnih žila jer one mogu utjecati na funkciju lijeve klijetke.Bolesnici i metode: U istraživanje je bilo uključeno 480 bolesnika s akutnim koronarnim sindromom (STEMI i NSTEMI). Zabilježene su sve početne karakteristike, kao i početna EF. Svi su bolesnici bili liječeni reperfuzijskom terapijom prema međunarodnim smjernicama. Nakon praćenja od godine dana EF je izmjerena ponovno.Rezultati: Žene su bile statistički značajno starije od muškaraca (P < 0,05). Postojala je značajna razlika u EF-u između žena i muškaraca (P < 0,05). Tijekom razdoblja praćenja nije bilo značajnih promjena u EF-u u skupini žena (P > 0,05). Životna dob i ženski spol pokazali su se neovisnim prediktorima promjene EF-a.Zaključak: Ženski je spol neovisan prediktor oporavka EF-a u bolesnika s akutnim koronarnim sindromom (STEMI i NSTEMI).SUMMaRY: Introduction: Previous gender-related studies on ejection fraction (EF) were single vessel specific and considered only patients with ST-segment elevation myocardial infarction (STEMI). This study evaluated the effect of gender on EF in acute coronary syndrome, including STEMI and non-STsegment elevation myocardial infarction (NSTEMI) as well as all blood vessels, since they can affect left ventricular function.Patients and Methods: 480 patients with acute coronary syndrome (STEMI and NSTEMI) were enrolled. All baseline characteristics along with EF were noted. All patients received reperfusion therapy as per international guidelines. Patients were followed up for one year, after which EF was reassessed.Results: Women were significantly older than men (P<0.05). There was significant difference between EF the between female and male groups (P<0.05). No significant change was seen in EF in the female group during follow-up (P>0.05). Age and female gender were found to be independent predictors of change in EF. Conclusion:Female gender is an independent predictor of recovery of EF in patients with acute coronary syndrome (STEMI and NSTEMI).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsunclassified

Section: Raspravaunclassified

mentioning

confidence: 99%

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The Relationship Between Gender and Ejection Fraction in Patients with Acute Coronary Syndrome after Reperfusion Therapy

Altaf¹,

Shah²

2019

Cardiologia Croatica

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Gender Disparities in Presentation, Management, and Outcomes of Acute Myocardial Infarction

Liakos

Parikh

2018

Curr Cardiol Rep

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While AMI continues to be a leading cause of mortality in both men and women, significant gender differences exist in presentation, management, and outcomes. Women with AMI are older, suffer atypical symptoms, and more often present with HF and cardiogenic shock. Delays in medical care and hence longer ischemic times exist in women, partly due to decreased awareness and lack of symptom recognition. Women continue to be less likely to receive guideline-based pharmacological therapies and revascularization than men with AMI. While women suffer from significantly higher risk-adjusted rates of bleeding, vascular complications, and short-term mortality, the risk-adjusted rates of long-term mortality remain similar between men and women. Further investigations and efforts are needed to aggressively modify risk factors, reduce delays in care, and address the higher rates of adverse events seen in women with AMI. Significant sex disparities are prevalent in presentation, management, and outcomes of adults with AMI. Further investigations and efforts are needed to aggressively modify risk factors, reduce delays in care, and address the higher rates of adverse events seen in women with AMI.

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Gender Differences in Left Ventricular Function Following Percutaneous Coronary Intervention for First Anterior Wall ST-Segment Elevation Myocardial Infarction

Weissler‐Snir

Kornowski

Sagie

et al. 2014

The American Journal of Cardiology

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Effect of sex on recovery of ejection fraction in patients with anterior ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Abstract: These data suggest that being female is an independent determinant of LVEF recovery in patients with anterior myocardial infarction after primary PCI.

Cited by 7 publications

References 23 publications

The Relationship Between Gender and Ejection Fraction in Patients with Acute Coronary Syndrome after Reperfusion Therapy

The Relationship Between Gender and Ejection Fraction in Patients with Acute Coronary Syndrome after Reperfusion Therapy

Gender Disparities in Presentation, Management, and Outcomes of Acute Myocardial Infarction

Gender Differences in Left Ventricular Function Following Percutaneous Coronary Intervention for First Anterior Wall ST-Segment Elevation Myocardial Infarction

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