The Relationship Between Gender and Ejection Fraction in Patients with Acute Coronary Syndrome after Reperfusion Therapy

Abstract

Infarkt miokarda (MI) jedan je od glavnih uzroka smrti i pobola u cijelome svijetu, a perkutana koronarna intervencija (PCI) ima ključnu ulogu SAŽETAK: Uvod: Prethodna istraživanja o povezanosti spola i ejekcijske frakcije (EF) odnosila su se samo na jednožilnu koronarnu bolest te su uzimala u obzir samo bolesnike s akutnim infarktom miokarda s elevacijom ST-segmenta (STEMI). U ovom smo radu istražili učinak spola na EF u akutnome koronarnom sindromu, uključujući STEMI i akutni infarkt miokarda bez elevacije ST-segmenta (NSTEMI) kod koronarne bolesti svih krvnih žila jer one mogu utjecati na funkciju lijeve klijetke.Bolesnici i metode: U istraživanje je bilo uključeno 480 bolesnika s akutnim koronarnim sindromom (STEMI i NSTEMI). Zabilježene su sve početne karakteristike, kao i početna EF. Svi su bolesnici bili liječeni reperfuzijskom terapijom prema međunarodnim smjernicama. Nakon praćenja od godine dana EF je izmjerena ponovno.Rezultati: Žene su bile statistički značajno starije od muškaraca (P < 0,05). Postojala je značajna razlika u EF-u između žena i muškaraca (P < 0,05). Tijekom razdoblja praćenja nije bilo značajnih promjena u EF-u u skupini žena (P > 0,05). Životna dob i ženski spol pokazali su se neovisnim prediktorima promjene EF-a.Zaključak: Ženski je spol neovisan prediktor oporavka EF-a u bolesnika s akutnim koronarnim sindromom (STEMI i NSTEMI).SUMMaRY: Introduction: Previous gender-related studies on ejection fraction (EF) were single vessel specific and considered only patients with ST-segment elevation myocardial infarction (STEMI). This study evaluated the effect of gender on EF in acute coronary syndrome, including STEMI and non-STsegment elevation myocardial infarction (NSTEMI) as well as all blood vessels, since they can affect left ventricular function.Patients and Methods: 480 patients with acute coronary syndrome (STEMI and NSTEMI) were enrolled. All baseline characteristics along with EF were noted. All patients received reperfusion therapy as per international guidelines. Patients were followed up for one year, after which EF was reassessed.Results: Women were significantly older than men (P<0.05). There was significant difference between EF the between female and male groups (P<0.05). No significant change was seen in EF in the female group during follow-up (P>0.05). Age and female gender were found to be independent predictors of change in EF. Conclusion:Female gender is an independent predictor of recovery of EF in patients with acute coronary syndrome (STEMI and NSTEMI).