Effect of Sesame Oil on the Inhibition of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice

Mosayebi, Ghasem; Ghazavi, Ali; Salehi, H; Ma, Payani; Mr, Khazae

doi:10.3923/pjbs.2007.1790.1796

Cited by 22 publications

(10 citation statements)

References 34 publications

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“…Control mice (vehicle group) received saline (i.p.) containing 3% DMSO, as previously described [ 24 , 25 ]. The dose of trans-resveratrol was selected based on earlier reports, showing its antioxidant property with a concentration ranging from 8 to 40 mg/kg [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency

Carrizzo

Iside²,

Nebbioso

et al. 2022

Cell. Mol. Life Sci.

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Beyond well-assessed risk factors, cardiovascular events could be also associated with the presence of epigenetic and genetic alterations, such as the methylenetetrahydrofolate-reductase (MTHFR) C677T polymorphism. This gene variant is related to increased circulating levels of homocysteine (Hcy) and cardiovascular risk. However, heterozygous carriers have an augmented risk of cardiovascular accidents independently from normal Hcy levels, suggesting the presence of additional deregulated processes in MTHFR C677T carriers. Here, we hypothesize that targeting Sirtuin 1 (SIRT1) could be an alternative mechanism to control the cardiovascular risk associated to MTHFR deficiency condition. Flow Mediated Dilatation (FMD) and light transmission aggregometry assay were performed in subjects carrying MTHFR C677T allele after administration of resveratrol, the most powerful natural clinical usable compound that owns SIRT1 activating properties. MTHFR C677T carriers with normal Hcy levels revealed endothelial dysfunction and enhanced platelet aggregation associated with SIRT1 downregulation. SIRT1 activity stimulation by resveratrol intake was able to override these abnormalities without affecting Hcy levels. Impaired endothelial function, bleeding time, and wire-induced thrombus formation were rescued in a heterozygous Mthfr-deficient (Mthfr+/–) mouse model after resveratrol treatment. Using a cell-based high-throughput multiplexed screening (HTS) assay, a novel selective synthetic SIRT1 activator, namely ISIDE11, was identified. Ex vivo and in vivo treatment of Mthfr+/– mice with ISIDE11 rescues endothelial vasorelaxation and reduces wire-induced thrombus formation, effects that were abolished by SIRT1 inhibitor. Moreover, platelets from MTHFR C677T allele carriers treated with ISIDE11 showed normalization of their typical hyper-reactivity. These results candidate SIRT1 activation as a new therapeutic strategy to contain cardio and cerebrovascular events in MTHFR carriers.

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Section: Methodsmentioning

confidence: 99%

SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency

Carrizzo

Iside²,

Nebbioso

et al. 2022

Cell. Mol. Life Sci.

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“…Typical brain inflammatory cell infiltration was observed in EAE mice compared to sesame oil-treated mice. This result suggests that sesame oil effectively prevents disease progression in EAE, which may be related to the inhibition of oxidative stress [ 209 ].…”

Section: Natural Compounds Against Oxidative Stress In Animal Models ...mentioning

confidence: 99%

Potential Utility of Natural Products against Oxidative Stress in Animal Models of Multiple Sclerosis

Zha

Liu

et al. 2022

Antioxidants

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Multiple sclerosis (MS) is an autoimmune-mediated degenerative disease of the central nervous system (CNS) characterized by immune cell infiltration, demyelination and axonal injury. Oxidative stress-induced inflammatory response, especially the destructive effect of immune cell-derived free radicals on neurons and oligodendrocytes, is crucial in the onset and progression of MS. Therefore, targeting oxidative stress-related processes may be a promising preventive and therapeutic strategy for MS. Animal models, especially rodent models, can be used to explore the in vivo molecular mechanisms of MS considering their similarity to the pathological processes and clinical signs of MS in humans and the significant oxidative damage observed within their CNS. Consequently, these models have been used widely in pre-clinical studies of oxidative stress in MS. To date, many natural products have been shown to exert antioxidant effects to attenuate the CNS damage in animal models of MS. This review summarized several common rodent models of MS and their association with oxidative stress. In addition, this review provides a comprehensive and concise overview of previously reported natural antioxidant products in inhibiting the progression of MS.

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“…Vitamin D 3 resulted in reduction of multiple sclerosis (MS) symptoms such as cognitive dysfunction, in animals (Garcion et al, 2003;Mosayebi, Ghazavi, Payani, 2006), however, its mechanism has not been Vitamin D 3 mediates spatial memory improvement through nitric oxide mechanism in demyelinated hippocampus of rat Zahra Ataie, Samira Choopani, Forough Foolad, Fariba Khodagholi, Mahdi Goudarzvand yet cleared. There are some contradictory results that vitamin D 3 has dual effect on the cognition (Brouwer-Brolsma et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D3 mediates spatial memory improvement through nitric oxide mechanism in demyelinated hippocampus of rat

Ataie

Choopani

Foolad

et al. 2022

Braz. J. Pharm. Sci.

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Studies have revealed beneficial role of vitamin D 3 in neuro-cognitive function. There is also supporting evidence on the involvement of nitric oxide (NO) in the neuro-protective action. However, its over production could contribute to brain disorders. In this study, demyelination was induced by ethidium bromide (EB) injection into the right side of the hippocampus area of male rats. Vitamin D 3 was administered to rats for 7 and 28 days prior to behavioral experiments using Morris water maze (MWM). Travelled distance, time spent to reach the platform, and time spent in target zone, were considered for learning and spatial memory evaluation. Nitrite oxide (NO2 -) concentration was measured as an indicator for nitric oxide production. The time spent to reach the platform and the travelled distance were decreased significantly by 28 days of vitamin D 3 administration (compared to 7 days experiment). Time spent in target quadrant was significantly lowered by administered vitamin on day 28. Therefore, considering a number of studies that have shown the effect of vitamin D 3 on cognition, these findings could support their potential effect. Besides, nitric oxide concentration significantly differed in 28 days of vitamin D 3 treated group compared with the groups treated with EB or 7 days of vitamin D 3.

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Effect of Sesame Oil on the Inhibition of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice

Cited by 22 publications

References 34 publications

SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency

SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency

Potential Utility of Natural Products against Oxidative Stress in Animal Models of Multiple Sclerosis

Vitamin D3 mediates spatial memory improvement through nitric oxide mechanism in demyelinated hippocampus of rat

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