Effect of semen characteristics on pregnancy rate following intrauterine insemination

Dorjpurev, Uranchimeg; Kuwahara, Akira; Yano, Yumiko; Taniguchi, Takeo; Yamamoto, Yuri; Suto, A.; Tanaka, Yu; Matsuzaki, Takashi; Yasui, Toshiyuki; Irahara, Minoru

doi:10.2152/jmi.58.127

Cited by 42 publications

(41 citation statements)

References 27 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, a logistic regression analysis failed to identify a significant correlation between treatment outcome and other characteristics such as patient age, duration of infertility, the number of follicles and other semen parameters. This is in contrast with other published reports [1,37,39]. The lack of consensus in the literature clearly highlights the difficulties in finding reliable prognostic parameters for determining IUI outcome.…”

Section: Discussioncontrasting

confidence: 61%

“…On the other hand, Dorjpurev et al [39] showed that with a motility rate of ≥30% and a motile sperm concentration of ≥10 million/ml, IUI can be a useful tool for treating male subfertility. Kamath et al [40] reported that a duration of infertility of less than 5 years and a total motile spermatozoa count of more than 10 million are related to a better prognosis in IUI, and they found a trend toward a higher pregnancy rate with endometrial thickness > 6 mm.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of motile sperm organelle morphology examination (MSOME) for predicting pregnancy after intrauterine insemination

Akl¹,

Oliveira²,

Petersen³

et al. 2011

Fertility and Sterility

View full text Add to dashboard Cite

Background: Although the motile sperm organelle morphology examination (MSOME) was developed merely as a selection criterion, its application as a method for classifying sperm morphology may represent an improvement in the evaluation of semen quality. The aim of this study was to determine the prognostic value of normal sperm morphology using MSOME with regard to clinical pregnancy (CP) after intrauterine insemination (IUI). Methods: A total of 156 IUI cycles that were performed in 111 couples were prospectively analysed. Each subject received 75 IU of recombinant FSH every second day from the third day of the cycle. Beginning on the 10th day of the cycle, follicular development was monitored by vaginal ultrasound. When one or two follicles measuring at least 17 mm were observed, recombinant hCG was administered, and IUI was performed 12-14 h and 36-40 h after hCG treatment. Prior to the IUI procedure, sperm samples were analysed by MSOME at 8400× magnification using an inverted microscope that was equipped with DIC/Nomarski differential interference contrast optics. A minimum of 200 motile spermatozoa per semen sample were evaluated, and the percentage of normal spermatozoa in each sample was determined. Results: Pregnancy occurred in 34 IUI cycles (CP rate per cycle: 21.8%, per patient: 30.6%). Based on the MSOME criteria, a significantly higher percentage of normal spermatozoa was found in the group of men in which the IUI cycles resulted in pregnancy (2.6+/-3.1%) compared to the group that did not achieve pregnancy (1.2+/-1.7%; P = 0.019). Logistic regression showed that the percentage of normal cells in the MSOME was a determining factor for the likelihood of clinical pregnancy (OR: 1.28; 95% CI: 1.08 to 1.51; P = 0.003). The ROC curve revealed an area under the curve of 0.63 and an optimum cut-off point of 2% of normal sperm morphology. At this cut-off threshold, using the percentage of normal sperm morphology by MSOME to predict pregnancy was 50% sensitive with a 40% positive predictive value and 79% specificity with an 85% negative predictive value. The efficacy of using the percentage of normal sperm morphology by MSOME in predicting pregnancy was 65%.

show abstract

Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Efficacy of motile sperm organelle morphology examination (MSOME) for predicting pregnancy after intrauterine insemination

Akl¹,

Oliveira²,

Petersen³

et al. 2011

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

“…However, contradictory conclusions have also been reported. Ibérico et al (19) and Dorjpurev et al (23) proposed that infertility type (primary or secondary) did not affect gestational rates (19,23).…”

Section: Discussionmentioning

confidence: 99%

Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

Atasever¹,

Kalem²,

Hatırnaz³

et al. 2016

J Turkish German Gynecol Assoc

View full text Add to dashboard Cite

Objective:The aim of the present retrospective study was to evaluate intrauterine insemination (IUI) clinical experiences and to define the variables for predicting success. Material and Methods:The present study was an observational trial performed in a private IVF center on subfertile couples who had applied for treatment between 2002 and 2012, in which the data of 503 IUI cases were retrospectively reviewed. Couples who had been diagnosed with unexplained and mild male subfertility were included. The primary outcome measure was the clinical pregnancy rate in an attempt to form a predictive model for the odds of a clinical pregnancy. Recorded parameters were used to determine the prediction model. Results:Utilizing univariate logistic regression analysis, clinical pregnancy was positively associated with the duration of infertility (OR=1.09, p=0.089), secondary infertility (OR=1.77, p=0.050), and +4 sperm motility after preparation (OR=1.03, p=0.091). Following an adjustment analysis involving a multivariate logistic regression, clinical pregnancy was still found to positively associate with secondary infertility (OR=2.51, p=0.008). Conclusion:IUI success in secondary infertile couples who were in the unexplained infertility and mild male subfertility groups was higher than that in primary infertile couples, and the chances of pregnancy increased as sperm numbers with +4 motility increased. It is difficult to concomitantly evaluate all these parameters and to determine a predictive parameter in IUI independent from other factors. (J Turk Ger Gynecol Assoc 2016; 17: 134-8) Keywords: Intrauterine insemination, unexplained infertility, male subfertility Received: 1 April, 2016 Accepted: 25 July, 2016 Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

show abstract

“…Pregnancy rates after IUI differ between studies according to patient selection criteria, the presence of various infertility factors, ovarian stimulation methods, number of cycles performed, different sperm parameters and preparation technique. 2 Objectives of present study were…”

Section: Introductionmentioning

confidence: 99%

Factors determining successful intrauterine insemination

Sinha

Pandey

Srivastava

2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Infertility is defined as failure to conceive even after one year of regular, frequent and unprotected intercourse. Infertility can be attributed to male causes in approximately 25-40% cases, female causes in 40-50% cases, both in 10-20% and unexplained causes in 10-15% cases. Artificial insemination (Intrauterine Insemination) involves placement of processed sperms from husband (AIH – artificial insemination homologous) or from donor (AID – artificial insemination donor) into the female genital tract.Methods: Objectives of the study were to do sperm preparation to obtain normal good quality motile sperms, to perform intrauterine insemination using husband semen around the time of ovulation, to study factors responsible for successful pregnancy rates by this method. Out of 100 infertile females recruited for the study 34 underwent artificial insemination by IUI with controlled ovarian hyper stimulation. Sperms were washed by density gradient centrifugation or by a direct swim-up technique that does not involve centrifugation.Results: Overall pregnancy rate per patient for male factor infertility was 23.52%. None of the patients consented for more than three cycles of IUI. Maximum pregnancy was achieved in third cycle of IUI. Sperm motility >40% was related with pregnancy in 8 cases. Duration of infertility didn’t influence pregnancy rate. The majority of pregnancies were achieved in the age group of 25-29 years (50%). No pregnancy occurred with >15 years of infertility.Conclusions: This study concluded that intrauterine insemination after ovarian stimulation or controlled ovarian hyperstimulation is a successful and efficacious therapy for infertility.

show abstract

Effect of semen characteristics on pregnancy rate following intrauterine insemination

Cited by 42 publications

References 27 publications

Efficacy of motile sperm organelle morphology examination (MSOME) for predicting pregnancy after intrauterine insemination

Efficacy of motile sperm organelle morphology examination (MSOME) for predicting pregnancy after intrauterine insemination

Factors affecting clinical pregnancy rates after IUI for the treatment of unexplained infertility and mild male subfertility

Factors determining successful intrauterine insemination

Contact Info

Product

Resources

About