Effect of selenium on sheep lymphocyte responses to mitogens

Larsen, H. J.; Øvernes, Gunnar; Moksnes, Knut

doi:10.1016/s0034-5288(18)30887-7

Cited by 31 publications

(8 citation statements)

References 21 publications

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“…Synergism between selenium and vitamin E has been demonstrated by the significant increase in lymphocyte counts in healthy sheep (Larsen et al., 1988) and pregnant sows (Mavromatis et al., 1999), but was not seen in this experiment. Lymphocytes are considered the population of cells most sensitive to ROS due to the high level of free fatty acids in their membranes (Nemec et al., 1990).…”

Section: Resultsmentioning

confidence: 47%

SHORT COMMUNICATION: Neutrophil oxidative metabolism and haemogram of sheep experimentally infected with Haemonchus contortus and supplemented with selenium and vitamin E

Camargo

Lopes

Costa

et al. 2010

Journal of Animal Physiology and Animal Nutrition

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The objective of this study was to evaluate neutrophil oxidative metabolism and haemogram in sheep experimentally infected with Haemonchus contortus and supplemented with selenium and vitamin E. Twenty male Corriedale sheep were utilised and distributed into four experimental groups each with five animals infected with larvae: G1--supplemented with sodium selenite, 0.2 mg/kg body weight (bw) given intramuscularly (IM); G2--supplemented with sodium selenite and vitamin E, 0.2 mg/kg bw and 2000 IU per animal, respectively, both IM; G3--supplemented with vitamin E, 2000 IU per animal IM; G4--not supplemented. A haemogram and the number of parasite eggs were determined in samples of blood and faeces, respectively, on days zero (T0), 20 (T1), 40 (T2) and 60 (T3) and nitroblue tetrazolium (NBT) assays were performed on heparinized blood samples taken on days zero, 30 and 60. A lower total leucocyte count was detected in G1 in relation to G4 at T4. Lymphocytes were reduced in G1 in relation to G3 and G4 at T3. In both non-stimulated (NBT-NS) and stimulated (NBT-S) dye reduction assays, there was reduced activity at 60 days, in relation to other times in the groups treated with selenium (G1 and G2). On the basis of results obtained, we conclude that supplementation with selenium provides better antioxidant protection to neutrophils.

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Section: Resultsmentioning

confidence: 47%

SHORT COMMUNICATION: Neutrophil oxidative metabolism and haemogram of sheep experimentally infected with Haemonchus contortus and supplemented with selenium and vitamin E

Camargo

Lopes

Costa

et al. 2010

Journal of Animal Physiology and Animal Nutrition

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“…Thus, a relatively narrow range of selenium concentrations must be maintained for optimal function of the immune system. 2,3,7,12,13,16,21,25,27,29,30,32 This study and results of a field investigation failed to clarify the association between subclinical selenium toxicosis and abortion/perinatal mortality. However, data from a limited number of animals suggest that current values indicative of perinatal selenium toxicosis (Ն3 ppm) may underestimate the resistance of animals to chronic selenium toxicosis and that marked elevations in hepatic selenium concentration (Ͼ9 ppm) may be clinically relevant.…”

Section: Discussionmentioning

confidence: 78%

The Effect of Subclinical Selenium Toxicosis on Pregnant Beef Cattle

et al. 1998

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Abstract. A field investigation conducted by the South Dakota Animal Disease Research and DiagnosticLaboratory suggested that subclinical selenium toxicosis in pregnant cows may have contributed to an outbreak of aborted/stillborn calves in a high-selenium region of South Dakota. This study was undertaken to evaluate the relationship between abortion and subclinical selenium toxicosis in the dam and to assess the effects of subclinical selenium toxicosis on the bovine immune system. Fifteen pregnant cows were fed diets containing 0.25 (control), 6.0, and 12.0 ppm selenium beginning at 80-110 days gestation. Although selenium toxicosis has been reported to cause abortion, this study failed to reproduce abortions. A single cow in the 12-ppm selenium treatment group gave birth to a weak calf, which subsequently died. This calf had myocardial lesions consistent with those described for selenium toxicosis and had hepatic selenium levels of 9.68 ppm (wet weight). Elevated dietary selenium resulted in the depression of several leukocyte function parameters in pregnant cows. A statistically significant depression in forced antibody response was identified in both selenium-supplemented groups. A significantly diminished mitogenic response to concanavalin A and pokeweed mitogen was also observed in the 12-ppm selenium group. Although a similar pattern of depression was also observed with phytohemagglutinin, differences were not significant. These findings indicate that even in the absence of clinical alkali disease, elevated selenium levels may adversely affect both pregnancy outcome and the bovine immune system.

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“…Selenium, copper, zinc, cobalt, molybdenum and iron have been shown to alter components of the immune system (28,44–46) as has chromium (13), with deficiency associated with reduced responses to pathogens and antigens. Deficiencies in selenium (47–49), copper (45), cobalt (50,51) and molybdenum (52–54) have been reported to reduce disease resistance. However, the effects are not consistent, which may reflect the range and complexity of the in vivo experimental systems used, or the multifactorial nature of susceptibility to disease.…”

Section: Influence Of Minerals On Immunity In Livestockmentioning

confidence: 99%

How minerals may influence the development and expression of immunity to endoparasites in livestock

McClure

2007

Parasite Immunology

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This review attempts to explain how dietary mineral intake may affect the immune system, with particular reference to gastrointestinal nematode infestations of livestock, and considers its significance for other gut infections as well as for other species. Of the 56 minerals found in mammalian tissues, 16 are currently considered to be essential, and a further 13 probably essential, for cell and tissue function. To date, eight of these have been shown to affect the function of the mammalian immune system directly. Nine others have roles in physiological pathways such as neurological or endocrine function, or protein or carbohydrate metabolism, which in turn regulate the immune system. The remainder may in the future be shown to have immunologically specific roles. The pathogenesis of mineral effects on immunity involves a number of pathways and molecular mechanisms. Major areas requiring further investigation are the relationship between deficiency of minerals and in vivo immune-mediated protection against disease, in particular diseases of the mucosa, and the mechanisms by which the minerals or their deficiency exert their effect on immunity. Research is also required into the possibility that animals in the process of acquiring gut immunity have higher requirements for minerals.

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Effect of selenium on sheep lymphocyte responses to mitogens

Cited by 31 publications

References 21 publications

SHORT COMMUNICATION: Neutrophil oxidative metabolism and haemogram of sheep experimentally infected with Haemonchus contortus and supplemented with selenium and vitamin E

SHORT COMMUNICATION: Neutrophil oxidative metabolism and haemogram of sheep experimentally infected with Haemonchus contortus and supplemented with selenium and vitamin E

The Effect of Subclinical Selenium Toxicosis on Pregnant Beef Cattle

How minerals may influence the development and expression of immunity to endoparasites in livestock

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