Effect of Salvia leriifolia leaf extract on morphine dependence in mice

Abstract

The effect of Salvia leriifolia leaf extract on morphine dependence was investigated in mice. Dependence was induced using subcutaneous injections of morphine daily for 3 days. On day 4, morphine was injected 2 h before the intraperitoneal injection of naloxone. The number of episodes of jumping during the 30 min after injection of naloxone was considered as the intensity of the withdrawal syndrome. The ethanol extract reduced the number of jumping episodes dose-dependently. The extract at a dose of 500 mg/kg was as effective as a dose of 5 mg/kg of diazepam in reducing the number of jumping episodes. The effect of the extract was blocked by aminophylline (20 mg/kg), a non-selective antagonist of adenosine receptors. It is concluded that the ethanol extract of S. leriifolia leaves could diminish the withdrawal syndrome of morphine.

Salvia officinalis L. attenuates morphine analgesic tolerance and dependence in rats: possible analgesic and sedative mechanisms

“…As it has been reported that some Salvia spp. increase ATP levels in the brain (4,9,31) and ATP is broken down to adenosine, it might be possible that the extract decreased morphine dependence by an adenosine related mechanism. Further studies are needed to confirm this mechanism.…”

“…Polyphenols and flavonoids are the major antioxidants of the SO extract (31). High antioxidant activity of SO and these compounds has been demonstrated in the previous studies (10,32).…”

“…Mey. attenuate morphine dependence in mice (8,9). Salvia officinalis L. (SO) (common sage), an aromatic plant which can be found worldwide, has broad pharmacological effects on the central nervous system (CNS) including neuroprotective (4), antioxidant (10), antinociception (11) and memory enhancing (12) effects.…”

Evaluation of antinociceptive effect of Aegiceras corniculatum stems extracts and its possible mechanism of action in rodents

“…Morphine dependence was induced in mice as described by Hosseinzadeh and Lary (2000). Morphine (50, 50 and 75 mg/kg) was injected subcutaneously (s.c.) thrice a day at 11:00 a.m., 14:00 and 17:00 p.m., respectively, for 3 consecutive days.…”

Labdane Diterpenoids from Salvia leriifolia: Absolute Configuration, Antimicrobial and Cytotoxic Activities

“…Due to the high percentage of oil and protein, the seeds are used as human and animal nutrition. A broad range of pharmacological activities have been reported, such as attenuation of morphine dependence [10], hypoglycemic [11], analgesic, anti-inflammatory [12,13], anticonvulsant [14], cytotoxic, antiproliferative [15,16], antioxidant, and cholinesterase inhibitory activities [17], antiulcer effects [18], and a protective effect on different markers of oxidative damage in muscle tissue caused by lower limb ischemiareperfusion [19]. Previous phytochemical investigations of S. leriifolia afforded a labdane diterpenoid [20], a novel diterpene-norditerpene conjugate [21], several abietane and rearranged abietane diterpenoids [21,22], lupane triterpenoids [22], and flavonoids [23].…”