Evaluation of antinociceptive effect of Aegiceras corniculatum stems extracts and its possible mechanism of action in rodents

Roome, Talat; Dar, Ahsana; Naqvi, Sabira; Choudhary, M. Iqbal

doi:10.1016/j.jep.2011.03.025

Cited by 24 publications

(13 citation statements)

References 37 publications

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“…Moreover, Roome et al (2011) demonstrated that the ethyl acetate extract from the stems of Aegiceras corniculatum at doses of 10, 25, and 50 mg/kg caused significant antinociceptive effects. Furthermore, Ashok Kumar et al (2010) reported that methanol extracts of Amaranthus viridis (A. viridis), A. caudatus , and A. spinosus showed significant pain management effects in albino mice at a dose of 400 mg/kg ( P < 0.01), which was attributed to the presence of alkaloids, steroids, flavonoids, terpenoids, and phenolic compounds in these extracts [30, 57, 58, 63, 64]. …”

Section: Resultsmentioning

confidence: 99%

Antioxidant, Antinociceptive, and Anti-Inflammatory Effects of Carotenoids Extracted from Dried Pepper (Capsicum annuumL.)

Hernández-Ortega

Ortiz-Moreno

Hernández-Navarro

et al. 2012

Journal of Biomedicine and Biotechnology

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Carotenoids extracted from dried peppers were evaluated for their antioxidant, analgesic, and anti-inflammatory activities. Peppers had a substantial carotenoid content: guajillo 3406 ± 4 μg/g, pasilla 2933 ± 1 μg/g, and ancho 1437 ± 6 μg/g of sample in dry weight basis. A complex mixture of carotenoids was discovered in each pepper extract. The TLC analysis revealed the presence of chlorophylls in the pigment extract from pasilla and ancho peppers. Guajillo pepper carotenoid extracts exhibited good antioxidant activity and had the best scavenging capacity for the DPPH+ cation (24.2%). They also exhibited significant peripheral analgesic activity at 5, 20, and 80 mg/kg and induced central analgesia at 80 mg/kg. The results suggest that the carotenoids in dried guajillo peppers have significant analgesic and anti-inflammatory benefits and could be useful for pain and inflammation relief.

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Section: Resultsmentioning

confidence: 99%

Antioxidant, Antinociceptive, and Anti-Inflammatory Effects of Carotenoids Extracted from Dried Pepper (Capsicum annuumL.)

Hernández-Ortega

Ortiz-Moreno

Hernández-Navarro

et al. 2012

Journal of Biomedicine and Biotechnology

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“…Its fruit is green to pink in color and has a curved-cylindrical shape [43]. Folk medicinal practitioners from the Sindh region in Pakistan use the stem to treat rheumatism, painful arthritis, and inflammatory diseases [74,75]. A. corniculatum showed many potential pharmacological activities (Table 6).…”

Section: Resultsmentioning

confidence: 99%

Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves―A Comprehensive Review

et al. 2019

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Mangroves are ecologically important plants in marine habitats that occupy the coastlines of many countries. In addition to their key ecological importance, various parts of mangroves are widely used in folklore medicine and claimed to effectively manage a panoply of human pathologies. To date, no comprehensive attempt has been made to compile and critically analyze the published literature in light of its ethnopharmacological uses. This review aims to provide a comprehensive account of the morphological characteristics, ethnobotany, global distribution, taxonomy, ethnopharmacology, phytochemical profiles, and pharmacological activities of traditionally used mangroves. Out of 84 mangrove species, only 27 species were found to be traditionally used, however not all of them are pharmacologically validated. The most common pharmacological activities reported were antioxidant, antimicrobial, and antidiabetic properties. Mangroves traditionally reported against ulcers have not been extensively validated for possible pharmacological properties. Terpenoids, tannins, steroids, alkaloids, flavonoids, and saponins were the main classes of phytochemicals isolated from mangroves. Given that mangroves have huge potential for a wide array of medicinal products and drug discovery to prevent and treat many diseases, there is a dire need for careful investigations substantiated with accurate scientific and clinical evidence to ensure safety and efficient use of these plants and validate their pharmacological properties and toxicity.

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“…In this assay, mice were placed on a heated (50 ± 0.05°C) metal plate and the time elapsed until the appearance of reactions (lifting or licking of the paws) to the thermal stimulus was recorded as an index of nociception [24, 25]. A cut-off period of 30 s was imposed to avoid tissue damage to the paws.…”

Section: Methodsmentioning

confidence: 99%

Ficus hispida Bark Extract Prevents Nociception, Inflammation, and CNS Stimulation in Experimental Animal Model

Msi

Siraj

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Background. Ficus hispida is traditionally used in the ailment of pain, inflammation, and neurological disorders. The present study set out to evaluate the in vivo antinociceptive, anti-inflammatory, and sedative activity of the ethanol extract of Ficus hispida bark (EFHB). Methods. The antinociceptive activity of EFHB was evaluated by using acetic acid induced writhing, formalin, hot plate, and tail immersion methods in Swiss albino mice. Its anti-inflammatory activity was assessed by using carrageenan and histamine induced rat paw oedema test in Wister rats. The central stimulating activity was studied by using pentobarbital induced hypnosis, hole cross, and open field tests in Swiss albino mice. Results. EFHB demonstrated antinociceptive activity both centrally and peripherally. It showed 62.24% of writhing inhibition. It significantly inhibited licking responses in early (59.29%) and late phase (71.61%). It increased the reaction time to the thermal stimulus in both hot plate and tail immersion. It inhibited the inflammation to the extent of 59.49%. A substantial increase in duration of sleep up to 60.80 min and decrease of locomotion up to 21.70 at 400 mg/kg were also observed. Conclusion. We found significant dose dependent antinociceptive, anti-inflammatory, and sedative properties of EFHB in experimental animal models.

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Evaluation of antinociceptive effect of Aegiceras corniculatum stems extracts and its possible mechanism of action in rodents

Cited by 24 publications

References 37 publications

Antioxidant, Antinociceptive, and Anti-Inflammatory Effects of Carotenoids Extracted from Dried Pepper (Capsicum annuumL.)

Antioxidant, Antinociceptive, and Anti-Inflammatory Effects of Carotenoids Extracted from Dried Pepper (Capsicum annuumL.)

Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves―A Comprehensive Review

Ficus hispida Bark Extract Prevents Nociception, Inflammation, and CNS Stimulation in Experimental Animal Model

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