<i>Salvia officinalis</i> L. attenuates morphine analgesic tolerance and dependence in rats: possible analgesic and sedative mechanisms

Hasanein, Parisa; Far, Masoud Teimuri; Emamjomeh, Abbasali

doi:10.3109/00952990.2015.1062893

Cited by 12 publications

(4 citation statements)

References 35 publications

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“…Among these are that it might diminish morphine's undesirable side effects. These include tolerance and dependence (Cowan and Macfarlane, 1975;Nozaki et al, 1975;Hasanein et al, 2015;Salmanzadeh et al, 2017), inhibition of gastrointestinal motility (Niwa et al, 2002;Gallantine and Meert, 2008), and respiratory depression (Emery et al, 2016;Whiteside et al, 2016). These preceding reports show that these adverse effects of morphine are dose dependent, and that the doses of morphine used in the present studies in combination with CRAs are sufficiently low that they would have the possibility of obviating the development of at least some of these adverse effects.…”

Section: Discussionmentioning

confidence: 61%

Coadministration of Chemokine Receptor Antagonists with Morphine Potentiates Morphine’s Analgesic Effect on Incisional Pain in Rats

Inan

Eisenstein

Watson

et al. 2018

J Pharmacol Exp Ther

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Crossdesensitization between opioid and chemokine receptors and involvement of chemokines in pain modulation are well established. We investigated if coadministration of chemokine receptor antagonists (CRAs) with morphine would enhance the analgesic potency of morphine on incisional pain in rats. Animals underwent incisional surgery on the left hind paw and pain responses were evaluated using von Frey filaments at various time points postsurgery between 15 and 360 minutes and daily between 24 and 72 hours. Dose-response curves for morphine, maraviroc (a CCR5 antagonist), and AMD3100 (a CXCR4 antagonist) alone were established. While morphine significantly reduced pain in a time-and dose-dependent manner, maraviroc and AMD3100 had no effect by themselves. Coadministration of either maraviroc or AMD3100 with morphine significantly increased morphine's analgesic effect on incisional pain, shifting the dose-response curve to the left 2.3and 1.8-fold, respectively. Coadministration of both CRAs with morphine significantly shifted further the morphine doseresponse curve to the left 3.3-fold. The effect of treatments on mRNA levels in the draining popliteal lymph node for a panel of chemokines and cytokines showed that message for many of these mediators was upregulated by the incision, and the combination of morphine with the CRAs markedly downregulated them. The data show that combining morphine with CRAs potentiates morphine's analgesic effect on incisional pain. Thus, the same analgesic effect of morphine alone can be achieved with lower doses of morphine when combined with CRAs. Using morphine in lower doses could reduce unwanted side effects and possibly block development of tolerance and dependence.

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Section: Discussionmentioning

confidence: 61%

Coadministration of Chemokine Receptor Antagonists with Morphine Potentiates Morphine’s Analgesic Effect on Incisional Pain in Rats

Inan

Eisenstein

Watson

et al. 2018

J Pharmacol Exp Ther

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“…Furthermore, concomitant treatment with SO 800 mg/kg and morphine prevented the development of tolerance to the analgesic effect of morphine on day 7 of morphine administration. These results showed that SO may decrease tolerance induced by repeated morphine administration [20].…”

Section: Neurobiological Effects Analgesic and Anti-inflammatory Effectsmentioning

confidence: 63%

“…increased percentage of maximum possible effect (%MPE) compared to vehicle group [20]. Furthermore, concomitant treatment with SO 800 mg/kg and morphine prevented the development of tolerance to the analgesic effect of morphine on day 7 of morphine administration.…”

Section: Neurobiological Effects Analgesic and Anti-inflammatory Effectsmentioning

confidence: 97%

Recent Studies on the Neuropharmacological Effects of Salvia officinalis L.: A Promising Candidate for Alzheimer's Disease

Hasanein¹,

Sharifi²,

Emamjomeh³

2017

Med chem

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Salvia is the largest genus of the Lamiaceae family including about 100 species. Salvia officinalis L. (SO) is one of the most appreciated herbs for richness of the essential oil content and its numerous biologically active compounds. SO has been used in herbal medicine for many centuries. In Islamic literature, it is considered as one of the greatest forms of healing medicine. The leaves of the plant have a wide range of biological activities, such as anti-bacterial, fungistatic, virustatic, anticancer, astringent, eupeptic and antihydrotic effects. Recently, this plant has been focused for its application in traditional medicine as well as to find new neurobiological properties. In this review, the up-todate information on the neurobiological effects of SO on the central nervous system will be reviewed. These include analgesic, memory enhancing, neuroprotective, anticonvulsant, anti-addictive, sedative, anxiolytic, and skeletal muscle relaxant effects. Furthermore, chemical compounds responsible for these effects and the clinical studies on this plant are presented and discussed.

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“…Morphine appears to be the most active metabolite of heroin, therefore, the effects of morphine are important in understanding the ramifications of heroin abuse 1 . Chronic opioids induces a variety of changes in the nervous system resulting in dependence 2 , 3 . Opioid dependence is characterized by the withdrawal reaction (physical dependence) and/or the presence of a “drug-craving” component (psychological dependence) 4 .…”

Section: Introductionmentioning

confidence: 99%

MnSOD mediated by HSV vectors in the periaqueductal gray suppresses morphine withdrawal in rats

Iida

Liu

et al. 2017

Gene Ther

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Morphine appears to be the most active metabolite of heroin; therefore, the effects of morphine are important in understanding the ramifications of heroin abuse. Opioid physical dependence (withdrawal response) may have very long-lasting effects on the motivation for reward, including the incubation of cue-induced drug-seeking behavior. However, the exact mechanisms of morphine withdrawal (MW) are not clear yet, and its treatment remains elusive. Periaqueductal gray (PAG) is one of the important sites in the pathogenesis of MW. Here, we used recombinant herpes simplex virus (HSV) vectors that encode the sod2 gene expressing manganese superoxide dismutase (MnSOD) to evaluate its therapeutic potential in MW. Microinjection of HSV vectors expressing MnSOD into the PAG reduced the MW syndrome. MnSOD vectors suppressed the upregulated mitochondrial superoxide, and endoplasmic reticulum stress markers (glucose-related protein 78 (GRP78) and activating transcription factor 6 alpha (ATF6α)) in the PAG induced by MW. Immunostaining showed that mitochondrial superoxide, GRP78 and ATF6α were colocalized with neuronal nuclei (a neuronal-specific marker), suggesting that they are located in the neurons in the PAG. These results suggest that overexpression of MnSOD by HSV vectors may relieve opioid dependence. This study may provide a novel therapeutic approach to morphine physical withdrawal response.

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Salvia officinalis L. attenuates morphine analgesic tolerance and dependence in rats: possible analgesic and sedative mechanisms

Cited by 12 publications

References 35 publications

Coadministration of Chemokine Receptor Antagonists with Morphine Potentiates Morphine’s Analgesic Effect on Incisional Pain in Rats

Coadministration of Chemokine Receptor Antagonists with Morphine Potentiates Morphine’s Analgesic Effect on Incisional Pain in Rats

Recent Studies on the Neuropharmacological Effects of Salvia officinalis L.: A Promising Candidate for Alzheimer's Disease

MnSOD mediated by HSV vectors in the periaqueductal gray suppresses morphine withdrawal in rats

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