Effect of Resveratrol on Blood Rheological Properties in LPS-Challenged Rats

Wang, Ying; Hao, Cui; Niu, Fei; Liu, Shuo-Lin; Li, Yao; Zhang, Limin; Du, Hui-Bo; Zhao, Zi‐Gang; Niu, Chun‐Yu

doi:10.3389/fphys.2018.01202

Cited by 15 publications

(16 citation statements)

References 21 publications

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“…The WBCs in the LPSM and LPSH groups were lower than in the control group after administration on days 1, 3, and 5, as was also reported for pigs [4]. According to Wang et al [17], the reason for blood leukopenia was that the WBCs adhered to the endothelial cells after LPS injection, and the WBCs infiltrated into the tissue through the vascular endothelial barrier. The lower LPS dose (LPSL) did not affect the expressions of IFN-γ and TLR4 , whereas the higher doses (LPSM and LPSH) increased them to an even greater extent than the control group after the LPS challenge on days 1 and 3.…”

Section: Discussionsupporting

confidence: 62%

“…It occurs in high concentrations in grape skins, peanuts and wines and possesses anti-inflammatory, anti-cancerogen and antioxidant properties [8,9,10,11]. Studies involving resveratrol treatment in animals with inflammatory diseases have demonstrated downregulation of inflammation-induced biomarkers, including pro-inflammatory mediators ( IL-1β , IL-6 , TNF-α , MCP-1 , IFN-γ , and NF-κB ) [12,13,14,15] and upregulation of inflammation-reduced biomarkers, including anti-oxidant protein (SOD) and total WBC counts [16,17]. Calabrese et al [18] classified resveratrol as a hormetic modulator in diseases, which included inflammation and infections.…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Resveratrol Improves Systemic Inflammation Responses in LPS-Injected Lambs

Liang

Zhou

et al. 2019

Animals

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Simple SummaryChina’s livestock industry has been transforming from traditional extensive systems to highly intensive systems. Highly intensive livestock production often causes immune stress to animals, which makes them more susceptible to infections. The aim of this study was to examine whether resveratrol alleviates inflammation in lambs. Results showed that resveratrol attenuated the LPS-evoked inflammatory responses in lambs by suppressing expression levels of inflammatory cytokines and blocking NF-κB and MAPK signaling pathways. Based on these studies, resveratrol has the potential to be a promising therapeutic reagent for multiple inflammatory illnesses caused by immune stress. AbstractHighly intensive livestock production often causes immune stress to animals, which makes them more susceptible to infections. The aim of this study was to examine whether resveratrol (Res) alleviates inflammation in lambs. In Experiment 1, 16 male lambs were injected with lipopolysaccharides (LPS) at an initial dose of 0.25, 1.25, and 2.5 μg/kg body weight (BW) for 9 days. Average daily gain and blood parameters were measured and clinical symptoms were recorded. In Experiment 2, 20 male lambs were injected intravenously with LPS (0 mg/kg) + Res (0 mg), LPS (2.5 μg /kg) + Res (0 mg, 82.5 mg, 165 mg, 330 mg), 4 h after LPS injection. Jugular blood was collected from each lamb to determine white blood cell (WBC) counts and the expression of inflammatory genes. In Experiment 1, all LPS-treated lambs showed clinical signs of sickness including rhinorrhea, lethargy, and shivering, and systemic inflammatory responses of increased inflammatory genes levels and cortisol concentration. The lambs had increased respiratory and heart rates and rectal temperature and decreased average daily gain and feed intake. In Experiment 2, resveratrol significantly reduced WBCs and the expression levels of several genes associated with inflammation response (TLR4, NF-κB, c-jun) and inhibited the signaling cascades of NF-κB and MAPKs by down-regulating the expression levels of inflammatory cytokines (IL-1β, IL-4, IL-6, TNF-α, IFN-γ) induced by LPS. Resveratrol attenuated the LPS-evoked inflammatory responses in lambs by suppressing expression levels of inflammatory cytokines, and blocking NF-κB and MAPK signaling pathways.

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Protective Effect of Resveratrol Improves Systemic Inflammation Responses in LPS-Injected Lambs

Liang

Zhou

et al. 2019

Animals

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“…Nonetheless, Cottart et al confirmed that, despite the extensive research on the benefits derived from RE, there was not enough research conducted to assess its harmful effects [59], especially since human clinical studies are limited. For instance, RE can cause considerable reductions in white blood cell (WBC) counts and plasma IL-6 or TNF levels, as well as elevations of plasma alanine aminotransferase (ALT) levels [173,174]. In addition, high doses of RE (2-5 g per day) can lead to episodes of light and mild diarrhea, nausea, hypersensitivity, and anal pruritus [175].…”

Section: Resveratrol Can Lead To Hypersensitivity and Alteration Of Hmentioning

confidence: 99%

Potential Adverse Effects of Resveratrol: A Literature Review

Shaito

Posadino

Younes

et al. 2020

IJMS

392

293

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Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clinical trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects.In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.

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“…The effects of resveratrol on hemorheological parameters have already been evaluated in some animal and human trials; however, they have not been studied in heart failure [8,24].…”

Section: Discussionmentioning

confidence: 99%

“…In a previous in vivo study of our working group, moderate red wine consumption had beneficial effect on red blood cell aggregation and deformability in healthy volunteers. Moreover, a significant improvement of RBC deformability and platelet aggregation was observed after RES administration (10 mg daily for 3 months) in patients with chronic ischemic heart disease [8,23,24].…”

Section: Introductionmentioning

confidence: 94%

Hemorheological Alterations in Patients with Heart Failure with Reduced Ejection Fraction Treated by Resveratrol

Gal

Praksch

Kenyeres

et al. 2020

Cardiovascular Therapeutics

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Objectives. Several beneficial effects of resveratrol have already been published. This study evaluated the effect of resveratrol on the hemorheological parameters in patients with heart failure with reduced ejection fraction. Methods. In our double-blind, placebo-controlled human clinical trial, we enrolled 60 outpatients with heart failure. Patients were randomized into two groups: receiving either 100 mg resveratrol capsule daily or placebo for 3 months. Hematocrit was determined by microhematocrit centrifuge. Plasma and whole blood viscosity was evaluated by capillary viscometer. Erythrocyte aggregation was measured by both LORCA and Myrenne aggregometers. LORCA ektacytometer was used for measuring erythrocyte deformability. Exercise capacity was assessed by a 6-minute walk test. Results. Resveratrol treatment did not have any significant effect on hematocrit and viscosity. The erythrocyte deformability also remained unchanged. However, significant improvement of red blood cell aggregation was observed in the resveratrol group compared to baseline after 3 months. Furthermore, positive correlation was found between the exercise capacity and the hemorheological properties (Hct, WBV, and RBC aggregation and deformability) as well. Conclusion. These findings indicate that resveratrol can significantly reduce red blood cell aggregation, which may positively influence microcirculation, which may contribute to the improvement of tissue perfusion and oxygen supply in heart failure.

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Effect of Resveratrol on Blood Rheological Properties in LPS-Challenged Rats

Cited by 15 publications

References 21 publications

Protective Effect of Resveratrol Improves Systemic Inflammation Responses in LPS-Injected Lambs

Protective Effect of Resveratrol Improves Systemic Inflammation Responses in LPS-Injected Lambs

Potential Adverse Effects of Resveratrol: A Literature Review

Hemorheological Alterations in Patients with Heart Failure with Reduced Ejection Fraction Treated by Resveratrol

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