Effect of Regular and Decaffeinated Coffee on Serum Gastrin Levels

Multi‐parametric approach to identify coffee components that regulate mechanisms of gastric acid secretion

“…These results are in accordance with the previous findings of our group [7,9,11,24], which also demonstrated that the pro-secretory activity of C5HT depends on the number of carbons in the C-chain of the corresponding fatty acid [10]. Furthermore, the effect of CAFF on gastric acid secretion has been often described as pro-secretory [3,8,25].…”

The effect of coffee on gastric emptying and oro‐caecal transit time

“…It has been demonstrated previously that coffee affects several of these factors. Coffee stimulates release of gastrin [1,[23][24][25][26][27][28][29][30] and gastric acid secretion [1,27,[30][31][32]. It also promotes cholecystokinin release [33].…”

Quantitation of βN-Alkanoyl-5-hydroxytryptamides in Coffee by Means of LC-MS/MS-SIDA and Assessment of Their Gastric Acid Secretion Potential Using the HGT-1 Cell Assay

“…Addition of petroleum ether (20 mL) led to the precipitation of the target compounds which were isolated by centrifugation and recrystallized from methanol, yielding the β N-d 2 -alkanoyl-5-hydroxytryptamides in a purity of more than 99% (LC-MS, 1 m/z (%) 160.1 (100), 177 (12). 1 H NMR (400 MHz, d 6 -DMSO): δ/ppm 0.84 (t, 3H, J = 7.1 Hz, H-C(28)), 1.15-1.30 (m, 12 Â 2H, 2 Â 1H, H-C (14)(15)(16)(17)(18)(20)(21)(22)(23)(24)(25)(26)(27), H-C (19,20)), 1.47 (m, 2H, H-C(13)), 2.03 (t, 2H, J = 7.4 Hz, H-C(12)), 2.69 (t, 2H, J = 7.4 Hz, H-C(8)), 3.25 (q, 2H, J = 6.6 Hz, H-C(9)), 6.56 (dd, 1H, J = 8.56 Hz, J = 2.02 Hz, H-C(6)), 6.80 (d, 1H, J = 2.02 Hz, H-C(4)), 6.99 (d, 1H, J = 1.77 Hz, H-C(2)), 7.10 (d, 1H, J = 8.6 Hz, H-C(7)), 7.82 (t, 1H, J = 5.56 Hz, H-N(10)), 8.54 (s, 1H, HO-C(5)), 10.44 (d, 1H, J = 1.77 Hz, H-N(1)). 13 C NMR (100 MHz, d 6 -DMSO): δ/ppm 14.08 (CH 3 , C(28)), 25.35 (CH 2 , C(8,13)), 22.17-34.47 (CDH, CH 2 , C(14-27)), 35.53 (CH 2 , C(12)), 39.75 (CH 2 , C(9)), 102.66 (CH, C(4)), 111.80 (CH, C(6,7)), 112.66 (C, C(3)), 123.39 (CH, C(2)), 128.06 (C, C(3 0 )), 131.07 (C, C(7 0 )), 150.84 (C-OH, C(5)), 172.32 (CdO, C(11)).…”

“…However, the number of consumers experiencing undesirable physiological symptoms, for example, stomach irritation or gastroesophageal reflux after ingestion is increasing (1)(2)(3)(4)(5)(6). As a consequence, these sensitive individuals have to avoid coffee consumption completely.…”