Effect of prebiotics of<i>Agave salmiana</i>fed to healthy Wistar rats

Jasso-Padilla, Iliana; Juárez-Flores, Bertha I.; Álvarez-Fuentes, Gregorio; Cruz-Martínez, Alejandro De la; González-Ramírez, José Enrique; Moscosa-Santillán, Mario; González‐Chávez, Marco Martín; Oros-Ovalle, Cuauhtémoc; Prell, Florian; Czermak, Peter; Martínez-Gutiérrez, Fidel

doi:10.1002/jsfa.7764

Cited by 23 publications

(14 citation statements)

References 38 publications

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“…These studies were primarily designed to analyze the prebiotic effects from agave fructans in in vitro studies [17–21], animal models [13, 22, 23] and clinical trials [24–27], whereas other studies have investigated the effects on food intake, body weight gain and hyperglycemia [11, 14, 22, 28]. Only one study has been conducted to analyze liver steatosis in diabetic rats supplemented with agave fructans [12], and several studies have been designed to investigate the relationship between dp and biological activity [13, 20, 21].…”

Section: Resultsmentioning

confidence: 99%

Fructans from Agave tequilana with a Lower Degree of Polymerization Prevent Weight Gain, Hyperglycemia and Liver Steatosis in High-Fat Diet-Induced Obese Mice

Márquez-Aguirre¹,

Camacho-Ruíz

Gutiérrez-Mercado³

et al. 2016

Plant Foods Hum Nutr

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Fructans from agave have received specific attention because of their highly branched fructan content. We have previously reported that the degree of polymerization (dp) influences their biological activity. Therefore, the aim of this study was to investigate the effect of unfractionated and fractionated fructans (higher and lower dps) from Agave tequilana in high-fat diet-induced (HFD) obese mice. Fructans with a lower dp (HFD+ScF) decreased weight gain by 30 %, body fat mass by 51 %, hyperglycemia by 25 % and liver steatosis by 40 %. Interestingly, unfractionated fructans (HFD+F) decreased glucose and triglycerides (TG), whereas fractionated fructans with a higher dp (HFD+LcF) decreased TG but not glucose; in contrast, HFD+ScF decreased glucose but not TG. Our findings suggest that both higher and lower dp agave fructans have complementary effects in metabolic disorders related to obesity. These findings may contribute to the development of improved food supplements with a specific ratio combination of fructans with different dps.Electronic supplementary materialThe online version of this article (doi:10.1007/s11130-016-0578-x) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Fructans from Agave tequilana with a Lower Degree of Polymerization Prevent Weight Gain, Hyperglycemia and Liver Steatosis in High-Fat Diet-Induced Obese Mice

Márquez-Aguirre¹,

Camacho-Ruíz

Gutiérrez-Mercado³

et al. 2016

Plant Foods Hum Nutr

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“…A number of studies have shown that beneficial bacterial additives, by changing the composition of the intestinal microflora and increasing the intestinal population of Lactobacillus, Bifidobacterium can help to lower cholesterol blood level [39][40][41]. Xie et al fed rats with a high cholesterol diet, Lactobacillus acidophilus M1-16 and Lactobacillus plantarum 9-41-A for 6 weeks.…”

Section: Dietary Influence On Hypercholesterolemic Ratsmentioning

confidence: 99%

Combined Lowering Effects of Rosuvastatin and L. acidophilus on Cholesterol Levels in Rat

Wang¹,

Zhou²,

Zhou³

et al. 2019

Journal of Microbiology and Biotechnology

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Statins are a class of lipid-lowering drugs commonly used in the prevention of cardiovascular diseases. However, statin therapy presents many limitations, which have led to an increased interest in non-drug therapies, such as probiotics, to improve blood cholesterol levels. Indeed, probiotic strains such as Lactobacillus acidophilus have been found to improve blood lipid profiles, especially in reducing total cholesterol and LDL-C levels. In this study, we established a high-cholesterol rat model and studied the effect of Lactobacillus acidophilus administration alone or in combination with rosuvastatin. We were able to show that Lactobacillus exerts a cholesterol-lowering effect. Additionally, we observed that when administered together, rosuvastin and Lactobacillus exert a combined cholesterol-lowering effect. Altogether, our data advocate for the possibility of establishing probiotics as non-drug supplements for the treatment of hypercholesterolemia.

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“…and Bifidobacterium spp. 76 Shifts of colonic microbiota composition induced by pectins were not as prominent as shifts of cecal microbiota in the study conducted by Tian et al 105 In the cecal microbiota the rise in Lactobacillus was also present, specifically in groups receiving lowmethyl esterified citrus pectin and sugar beet pectin.…”

Section: Insight Into Rat Intestinal Microbiota Modulation By Food Sumentioning

confidence: 80%

“…and Bifidobacterium spp . (CFU g −1 ) in both test groups (approximately 4-log increase was observed in the group with symbiotic food) 76 Feruloylated oligosaccharides (FOs) from maize bran 45, male Sprague–Dawley rats, weighing 160–170 g n = 9, normal feed n = 9, + 300 mg/kg BW/d xylooligosaccharides (XOS) n = 9,+ 300 mg/kg BW/d XOS + 12 mg/kg BW/d ferulic acid (FA) n = 9, + 300 mg/kg BW/d FOs n = 9, + 600 mg/kg BW/d FOs Feces collected and stored at −80°C. 5 weeks DNA extraction using TIAN amp Stool DNA kit PCR amplification sequencing on the Illumina GAIIx platform reference base from Ribosomal Database Project Feruloylated oligosaccharides showed even higher prebiotic activity than XOS FOs : ↑bacterial richness and diversity ↓ ratio of Firmicutes to Bacteroidetes ↑ Bacteroidetes , Proteobacteria, Actinobacteria, Lactobacillus and Ruminococcus ↓ Clostridia 77 Pectins (four types) 40, male Wistar rats (300 ± 10 g) n = 8, control group n = 8, 3% (w/w) low-methyl esterified citrus pectin (LMP) n = 8, 3% (w/w) high-methyl esterified citrus pectin (HMP) n = 8, 3% (w/w) sugar beet pectin (SBP) n = 8, 3% (w/w) soy pectin (SSPS) Cecal and colonic digesta collected separately.…”

Section: Gut Microbiota Shifts In Healthy Rat Models By Different Nutmentioning

confidence: 89%

Modulation of gut microbiota in healthy rats after exposure to nutritional supplements

2020

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Introduction: Rats are experimental animals, frequently used as model organisms in the biomedical studies, and increasingly used to study the gut microbiota. Specifically, the aim of latter studies is either the elucidation of relationship between intestinal dysbiosis and diseases or the determination of nutrients or pharmaceutical agents which can cause the modulation in the presence or abundance of gut microbiota. Aim: Herein, the research studies conducted on the gut microbiota of healthy rats are presented in a summarized and concise overview. The focus is on studies aimed to reveal the shifts in microbial composition and functional changes after exposure to various types of nutritional supplements. Methods: We performed the search of PubMed database using the term "rat gut microbiome microbiota" and examined studies aimed to assess the composition of gut microbiota in physiological homeostasis as well as the effect of various nutritional supplements on the gut microbiota of healthy rats.

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Effect of prebiotics ofAgave salmianafed to healthy Wistar rats

Cited by 23 publications

References 38 publications

Fructans from Agave tequilana with a Lower Degree of Polymerization Prevent Weight Gain, Hyperglycemia and Liver Steatosis in High-Fat Diet-Induced Obese Mice

Fructans from Agave tequilana with a Lower Degree of Polymerization Prevent Weight Gain, Hyperglycemia and Liver Steatosis in High-Fat Diet-Induced Obese Mice

Combined Lowering Effects of Rosuvastatin and L. acidophilus on Cholesterol Levels in Rat

Modulation of gut microbiota in healthy rats after exposure to nutritional supplements

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