Combined Lowering Effects of Rosuvastatin and L. acidophilus on Cholesterol Levels in Rat

Wang, Lijun; Zhou, Baihua; Zhou, Xue; Wang, Yan; Wang, Hongwei; Jia, Shengying; Zhang, Zhipeng; Chu, Chao; Mu, Jianjun

doi:10.4014/jmb.1806.06004

Cited by 20 publications

(18 citation statements)

References 51 publications

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“…A subset of patients on statins cannot achieve target plasma cholesterol levels even at the highest doses and decide to stop treatment altogether than deal with the side effects [ 115 ]. Co-therapy involving a statin in combination with a probiotic is another interesting avenue to explore that can exert a combine cholesterol-lowering effect thereby decreasing statin doses [ 116 ]. However, it is presently very difficult to utilize knowledge of microbiota composition and function in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

The Role of Gut Microbiota on Cholesterol Metabolism in Atherosclerosis

Vourakis

Mayer

Rousseau

2021

IJMS

112

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Hypercholesterolemia plays a causal role in the development of atherosclerosis and is one of the main risk factors for cardiovascular disease (CVD), the leading cause of death worldwide especially in developed countries. Current data show that the role of microbiota extends beyond digestion by being implicated in several metabolic and inflammatory processes linked to several diseases including CVD. Studies have reported associations between bacterial metabolites and hypercholesterolemia. However, such associations remain poorly investigated and characterized. In this review, the mechanisms of microbial derived metabolites such as primary and secondary bile acids (BAs), trimethylamine N-oxide (TMAO), and short-chain fatty acids (SCFAs) will be explored in the context of cholesterol metabolism. These metabolites play critical roles in maintaining cardiovascular health and if dysregulated can potentially contribute to CVD. They can be modulated via nutritional and pharmacological interventions such as statins, prebiotics, and probiotics. However, the mechanisms behind these interactions also remain unclear, and mechanistic insights into their impact will be provided. Therefore, the objectives of this paper are to present current knowledge on potential mechanisms whereby microbial metabolites regulate cholesterol homeostasis and to discuss the feasibility of modulating intestinal microbes and metabolites as a novel therapeutic for hypercholesterolemia.

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Section: Discussionmentioning

confidence: 99%

The Role of Gut Microbiota on Cholesterol Metabolism in Atherosclerosis

Vourakis

Mayer

Rousseau

2021

IJMS

112

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“…Oxidative stress is known to play a role in the course of CVD [59,60]. This p non refers to elevated intracellular levels of oxygen radicals that cause damage Due to the benefits to human health, prebiotics are increasingly used by the food industry as functional ingredients.…”

Section: Oxidative Stressmentioning

confidence: 99%

“…Oxidative stress is known to play a role in the course of CVD [59,60]. This phenomenon refers to elevated intracellular levels of oxygen radicals that cause damage to lipids, proteins, and DNA [61].…”

Section: The Influence Of Probiotics and Prebiotics On The Mechanisms And Factors Causing Cvd 61 Oxidative Stressmentioning

confidence: 99%

Role of Gut Microbiota, Probiotics and Prebiotics in the Cardiovascular Diseases

et al. 2021

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In recent years, there has been a growing interest in identifying and applying new, naturally occurring molecules that promote health. Probiotics are defined as “live microorganisms which, when administered in adequate amounts, confer health benefits on the host”. Quite a few fermented products serve as the source of probiotic strains, with many factors influencing the effectiveness of probiotics, including interactions of probiotic bacteria with the host’s microbiome. Prebiotics contain no microorganisms, only substances which stimulate their growth. Prebiotics can be obtained from various sources, including breast milk, soybeans, and raw oats, however, the most popular prebiotics are the oligosaccharides contained in plants. Recent research increasingly claims that probiotics and prebiotics alleviate many disorders related to the immune system, cancer metastasis, type 2 diabetes, and obesity. However, little is known about the role of these supplements as important dietary components in preventing or treating cardiovascular disease. Still, some reports and clinical studies were conducted, offering new ways of treatment. Therefore, the aim of this review is to discuss the roles of gut microbiota, probiotics, and prebiotics interventions in the prevention and treatment of cardiovascular disease.

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“…Reduction of cholesterol; reduced in type 2 diabetes; improvement of Irritable bowel syndrome (IBS) symptoms; reduced inflammation. [12][13][14][15][16]…”

Section: Lactobacillus Acidophilusmentioning

confidence: 99%

Microbiota and Probiotics: The Role of Limosilactobacillus Reuteri in Diverticulitis

et al. 2021

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The microbiota is the set of commensal microorganisms, residing in the organism, helping proper functioning of organs and systems. The role that the microbiota plays in maintaining the health of vertebrates is widely accepted, particularly in the gastrointestinal system, where it is fundamental for immunity, development, and conversion of nutrients. Dysbiosis is an alteration of the microbiota which refers to a disturbed balance, which can cause a number of pathologies. Probiotics have proven to be effective in modulating the microbiota of the gastrointestinal system and, therefore, in promoting the health of the individual. In particular, Lactobacilli are a group of Gram-positive bacteria, which are able to produce lactic acid through glucose metabolism. They are present in different microenvironments, ranging from the vagina, to the mouth, to different tracts of the small intestine. In the present review, we will discuss the use of Limosilactobacillus in human health in general and more specifically in diverticulitis. In particular we analyze the role of Limosilactobacillus reuteri and its anti-inflammatory action. For this review, articles were identified using the electronic PubMed database through a comprehensive search, conducted by combining key terms such as “diverticulitis”, “Limosilactobacillus reuteri”, “human health and disease”, “probiotics”. We selected all the articles published in the last 10 years and screened 1017 papers. Articles referenced in the screened papers were evaluated if considered interesting for our topic. Probiotics have proven to be effective in modulating the microbiota of the gastrointestinal system and, therefore, in promoting the health of the individual. The importance of probiotics in treating diverticular disease and acute diverticulitis can be further understood if taking into consideration some pathophysiological aspects, associated to the microbiota. L. reuteri plays an important role in human health and disease. The effectiveness of L. reuteri in stimulating a correct bowl motility partly explains its effectiveness in treating diverticulitis. The most important action of L. reuteri is probably its immunomodulating activity. Levels of IL-6, IL-8, and Tumor necrosis factor (TNF-alpha) are reduced after supplementation with different strands of Lactobacilli, while T-regulatory cells increase in number and activity. Anyway, new mechanisms of action of probiotics come to light from the many investigations currently taking place in numerous centres around the world and to improve how exactly probiotic administration could make the difference in the management of diverticular disease and acute diverticulitis.

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Combined Lowering Effects of Rosuvastatin and L. acidophilus on Cholesterol Levels in Rat

Cited by 20 publications

References 51 publications

The Role of Gut Microbiota on Cholesterol Metabolism in Atherosclerosis

The Role of Gut Microbiota on Cholesterol Metabolism in Atherosclerosis

Role of Gut Microbiota, Probiotics and Prebiotics in the Cardiovascular Diseases

Microbiota and Probiotics: The Role of Limosilactobacillus Reuteri in Diverticulitis

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