Effect of pomegranate extract on vagina, skeleton, metabolic and endocrine profiles in an ovariectomized rat model

Kaban, İşık; Kaban, Alpaslan; Tunca, Aysun Fendal; Aka, Nurettin; Kavak, Hacer; Akar, Fugen

doi:10.1111/jog.13642

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…Some RCTs have shown that low- or ultra-low-dose HT is effective for the relief of menopausal symptoms and maintaining bone mass with fewer adverse effects in postmenopausal Chinese women. Isik Kaban et al [31] suggested that pomegranate itself or its formulation extracts may support or be an alternative to the primary treatment modalities in the preservation of bone density and the treatment of vaginal epithelial atrophy in menopause. Phytoestrogen preparations are generally considered to be a safe alternative to HT [32].…”

Section: Discussionmentioning

confidence: 99%

Effect of Menopausal Hormone Therapy on Bone Mineral Density in Chinese Women: A 2-Year, Prospective, Open-Label, Randomized-Controlled Trial

et al. 2019

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BackgroundThis study was designed to explore the effect of menopausal hormone therapy (MHT) on bone mineral density (BMD) in Chinese women.Material/MethodsThis was a prospective, open-label, randomized-controlled clinical trial. We randomly assigned 123 postmenopausal women to 3 groups: group A received 0.625 mg conjugated equine estrogen (CEE) plus 100 mg micronized progesterone (MP), group B received 0.3 mg CEE daily plus 100 mg MP, and group C received 0.625 mg CEE daily plus 10 mg dydrogesterone (DHG). All subjects received a 2-year intervention and drugs were given in a continuous sequential pattern.ResultsNinety-six patients were followed up. At 1 year, groups A and B gained 2.31% and 1.95% BMD, respectively (P<0.01); at 2 years, groups B and C gained 2.37% and 4.15% BMD (P<0.01) respectively. At 2 years, group A gained 3.28% BMD in the femoral neck and 3.77% BMD in Ward’s triangle (P<0.05). At 1 year, group B lost 2.14% BMD in the trochanter and 1.20% BMD in the total hip (P<0.05); at 2 years, group B lost 1.51% BMD in the total hip (P<0.01). ALP, Ca, P, and Ca/Cr levels were all decreased in the 3 groups (P<0.05). The changes in Cr level at 1 and 2 years were not significant when compared with baseline in all groups (P>0.05).ConclusionsBoth lower-dose and standard-dose CEE increased lumbar BMD, sustain femoral neck BMD, and Ward’s triangle BMD, while there was a reduced bone turnover rate. Standard-dose CEE combined with MP can increase BMD at these 2 sites. CEE combined with MP is recommended because it has better clinical benefits.

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Section: Discussionmentioning

confidence: 99%

Effect of Menopausal Hormone Therapy on Bone Mineral Density in Chinese Women: A 2-Year, Prospective, Open-Label, Randomized-Controlled Trial

et al. 2019

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“…Further investigations claimed pomegranate extract containing polyphenols displays adequate efficacy on bone loss in menopausal women. It preserves bone mineral density and helps to increase the tibial bone cortex thickness by improving the estrogen level in the body (Hae‐yeon, 2009; Kaban et al, 2018; Mori‐Okamoto et al, 2004).…”

Section: Management Of Menopause and Related Disordersmentioning

confidence: 99%

“…This demands further investigations and clinical trials to prove its action. yeon, 2009;Kaban et al, 2018;Mori-Okamoto et al, 2004).…”

Section: Ginkgo (Ginkgo Biloba)mentioning

confidence: 99%

Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis

Mohapatra,

Kumar,

Aggarwal

et al. 2024

Phytotherapy Research

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Women face a significant change in their reproductive health as menopause sets in. It is marred with numerous physiological changes that negatively impact their quality of life. This universal, transition phase is associated with menopausal and postmenopausal syndrome, which may spread over 2–10 years. This creates a depletion of female hormones causing physical, mental, sexual and social problems and may, later on, manifest as postmenopausal osteoporosis leading to weak bones, causing fractures and ultimately morbidity and mortality. Menopausal hormone therapy generally encompasses the correction of hormone balance through various pharmacological agents, but the associated side effects often lead to cessation of therapy with poor clinical outcomes. However, it has been noticed that phytotherapeutics is trusted by women for the amelioration of symptoms related to menopause and for improving bone health. This could primarily be due to their reduced side effects and lesser costs. This review attempts to bring forth the suitability of phytotherapeutics/herbals for the management of menopausal, postmenopausal syndrome, and menopausal osteoporosis through several published research. It tries to enlist the available botanicals with their key constituents and mechanism of action for mitigating symptoms associated with menopause as well as osteoporosis. It also includes a list of a few herbal commercial products available for these complications. The article also intends to collate the findings of various clinical trials and patents available in this field and provide a window for newer research avenues in this highly important yet ignored health segment.

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“…3 Estrogen therapy given orally or vaginally was known successfully reduces the symptoms of vaginal atrophy like dryness, sexual dysfunction and vaginal atrophy. 4 Nevertheless, the long term effect of use estrogen may risk breast cancer, endometrial cancer and coronary heart disease. 3 Phytoestrogen is an alternative treatment to reduce the side effect of perimenopause.…”

Section: Introductionmentioning

confidence: 99%

Estrogenic Effect of the Leaves from Katuk (Sauropus androgynus L. Merr) on Vaginal and Endometrial Atrophy in Perimenopausal Mice

Susilowati¹,

Khoiriyah²,

Hikmah³

2020

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Objective: To examine the potency of estrogenic effect of Katuk (or star gooseberry or sweet leaf) Sauropus androgynus L. Merr (Phyllanthaceae) leaf extract on the vaginal and endometrial atrophy in perimenopausal mice model. Methods: Completely random experiments divided into 4 groups with 5 female mice in each group: control group (N), perimenopause group which induced by 4-vynil cyclohexene dioxide (VCD) (P0), perimenopause group followed by S. androgynus leaves extract administration with 15 and 30 mg/kg BW (P15 and P30). The mice were induced to artificial perimenopause with 160 mg/kg body weight (BW) of VCD 5 times/week for 2 weeks and continuously treated with S. androgynus leaf extract for 30 days. Vaginal smear examination, maturation index (MI), vaginal epithelium and endometrial thickness were observed. Data were analyzed using a standard one-way ANOVA with LSD Test by SPSS 16.0 for Windows. Results: Administration of S. androgynus leaf extract for 30 days to perimenopausal mice model significantly decreased the duration of mice diestrus phase (p<0.01) compared to perimenopause mice. S. androgynus leaf extract treatment at dose 30 mg/kg BW led to higher vaginal epithelium thickness and maturation index compared to another group (p<0.01). The effective dose to enhance the vaginal epithelial and endometrial cells proliferation was 30 mg/ kg BW. Conclusions: S. androgynus leaf extract had a good estrogenic action that it might be useful for therapy of vaginal and endometrial atrophy caused by perimenopause effect.

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Effect of pomegranate extract on vagina, skeleton, metabolic and endocrine profiles in an ovariectomized rat model

Cited by 5 publications

References 34 publications

Effect of Menopausal Hormone Therapy on Bone Mineral Density in Chinese Women: A 2-Year, Prospective, Open-Label, Randomized-Controlled Trial

Effect of Menopausal Hormone Therapy on Bone Mineral Density in Chinese Women: A 2-Year, Prospective, Open-Label, Randomized-Controlled Trial

Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis

Estrogenic Effect of the Leaves from Katuk (Sauropus androgynus L. Merr) on Vaginal and Endometrial Atrophy in Perimenopausal Mice

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