Effect of Polymorphisms of Three Genes Mediating Monoamine Signalling on Brain Morphometry in Schizophrenia and Healthy Subjects

Vijayakumari, Anupa A.; John, John P.; Halahalli, Harsha N.; Paul, Pradip; Thirunavukkarasu, Priyadarshini; Purushottam, Meera; Jain, Sanjeev

doi:10.9758/cpn.2015.13.1.68

Cited by 8 publications

(4 citation statements)

References 56 publications

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“…Many studies, including neuroimaging, genetic, or biochemical parameters, have been performed in an attempt to identify the neurobiology of schizophrenia. 1 – 3) Because of the mentioned burden of schizophrenia in patients’ lives, researchers focused on identifying markers that represent disease status and prognosis. Peripheral tissues like plasma, serum, and lymphocytes are easily accessible, and are thus convenient to investigate.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Dysregulation of Several MicroRNAs in Peripheral Blood of Schizophrenia Patients

Camkurt¹,

Karababa

Erdal

et al. 2016

Clin Psychopharmacol Neurosci

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ObjectiveThe prevalence of schizophrenia is 1%, and it is a debilitating disorder that often results in a shortened lifespan. Peripheral blood samples are good candidates to investigate because they can be easily drawn, and they are widely studied in psychiatric disorders. MicroRNAs are small non-coding RNA transcripts. They regulate the expression of genes by binding to the 3′-untranslated region (UTR) of mRNAs and pointing them to degrade. In this study, we aimed to investigate the expression of miR-9-5p, miR-29a-3p, miR-106-5p, miR-106b-5p, miR-107, miR-125a-3p, and miR-125b-3p in schizophrenia patients and healthy controls.MethodsWe collected blood samples from 16 patients with schizophrenia and 16 healthy controls. MicroRNAs were measured with reverse transcriptase polymerase chain reaction.ResultsSchizophrenia patients showed statistically significant upregulation of five microRNAs: miR9-5p (p=0.002), miR29a-3p (p<0.001), miR106b-5p (p=0.002), miR125a-3p (p<0.001), and miR125b-3p (p=0.018).ConclusionOur results increased the value of the miR106 and miR29 families as potentially and consistently dysregulated in psychiatric disorders. Our results should be considered preliminary, and they need confirmation in future studies with larger sample sizes.

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Section: Introductionmentioning

confidence: 99%

Investigation of Dysregulation of Several MicroRNAs in Peripheral Blood of Schizophrenia Patients

Camkurt¹,

Karababa

Erdal

et al. 2016

Clin Psychopharmacol Neurosci

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“…Indeed, a more logical strategy would be to examine the sources of the variability of morphometric findings across samples, most important of which are the molecular genetic factors. These factors might include genetic and epigenetic factors, including the individual and additive effects of the multiple genes responsible for schizophrenia diathesis on brain development, as recently reported from our laboratory [ 48 , 49 ].…”

Section: Discussionmentioning

confidence: 97%

A systematic examination of brain volumetric abnormalities in recent-onset schizophrenia using voxel-based, surface-based and region-of-interest-based morphometric analyses

John

Lukose

Bagepally

et al. 2015

J Negat Results BioMed

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BackgroundBrain morphometric abnormalities in schizophrenia have been extensively reported in the literature. Whole-brain volumetric reductions are almost universally reported by most studies irrespective of the characteristics of the samples studied (e.g., chronic/recent-onset; medicated/neuroleptic-naïve etc.). However, the same cannot be said of the reported regional morphometric abnormalities in schizophrenia. While certain regional morphometric abnormalities are more frequently reported than others, there are no such abnormalities that are universally reported across studies. Variability of socio-demographic and clinical characteristics across study samples as well as technical and methodological issues related to acquisition and analyses of brain structural images may contribute to inconsistency of brain morphometric findings in schizophrenia. The objective of the present study therefore was to systematically examine brain morphometry in patients with recent-onset schizophrenia to find out if there are significant whole-brain or regional volumetric differences detectable at the appropriate significance threshold, after attempting to control for various confounding factors that could impact brain volumes.MethodsStructural magnetic resonance images of 90 subjects (schizophrenia = 45; healthy subjects = 45) were acquired using a 3 Tesla magnet. Morphometric analyses were carried out following standard analyses pipelines of three most commonly used strategies, viz., whole-brain voxel-based morphometry, whole-brain surface-based morphometry, and between-group comparisons of regional volumes generated by automated segmentation and parcellation.ResultsIn our sample of patients having recent-onset schizophrenia with limited neuroleptic exposure, there were no significant whole brain or regional brain morphometric abnormalities noted at the appropriate statistical significance thresholds with or without including age, gender and intracranial volume or total brain volume in the statistical analyses.ConclusionsIn the background of the conflicting findings in the literature, our findings indicate that brain morphometric abnormalities may not be directly related to the schizophrenia phenotype. Analysis of the reasons for the inconsistent results across studies as well as consideration of alternate sources of variability of brain morphology in schizophrenia such as epistatic and epigenetic mechanisms could perhaps advance our understanding of structural brain alterations in schizophrenia.Electronic supplementary materialThe online version of this article (doi:10.1186/s12952-015-0030-z) contains supplementary material, which is available to authorized users.

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“… 1 – 4) Differences in age, gender, duration of illness, exposure to antipsychotic drug could contribute towards the variability of morphometric findings. 5) Many genetic and environmental factors have been indicated for the etiopathogenesis of schizophrenia. 6) Oxidant-antioxidant balance disorders lie under several disease of central nervous system.…”

Section: Introductionmentioning

confidence: 99%

Thiol Disulfide Homeostasis in Schizophrenic Patients Using Atypical Antipsychotic Drugs

Doğan

Erşan

Aydın

et al. 2018

Clin Psychopharmacol Neurosci

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ObjectiveSchizophrenia is a severe, debilitating mental disorder characterized by behavioral abnormalities. Although several studies have investigated the role of oxidative stress and the effects of antipsychotic drugs on oxidative markers in schizophrenia, adequate information is not available on these issues. The aim of this study is to determine the changes in oxidative status and thiol disulfide homeostasis in schizophrenic patients using atypical antipsychotic drugs.MethodsThirteen schizophrenic patients using atypical antipsychotic drugs and 30 healthy controls were included this study. The concentrations of total oxidant status (TOS), total antioxidant status (TAS), native thiol, total thiol, and disulfide levels were determined in the study population.ResultsThe TAS (p=0.001), total thiol, and native thiol levels (p<0.001) were higher in the patients compared to the controls, whereas the TOS and disulfide levels were lower in the patients than in the controls (p<0.001).ConclusionThese results may suggest that atypical antipsychotic drugs have a useful therapeutic effect by reducing oxidative stress via the inhibition of the formation of disulfide bonds. The study population number was one of the limitations of this study. Therefore, further studies are needed to establish the association between thiol disulfide homeostasis in schizophrenic patients using atypical antipsychotic drugs.

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Effect of Polymorphisms of Three Genes Mediating Monoamine Signalling on Brain Morphometry in Schizophrenia and Healthy Subjects

Cited by 8 publications

References 56 publications

Investigation of Dysregulation of Several MicroRNAs in Peripheral Blood of Schizophrenia Patients

Investigation of Dysregulation of Several MicroRNAs in Peripheral Blood of Schizophrenia Patients

A systematic examination of brain volumetric abnormalities in recent-onset schizophrenia using voxel-based, surface-based and region-of-interest-based morphometric analyses

Thiol Disulfide Homeostasis in Schizophrenic Patients Using Atypical Antipsychotic Drugs

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