Investigation of Dysregulation of Several MicroRNAs in Peripheral Blood of Schizophrenia Patients

Camkurt, Mehmet Akif; Karababa, Fatih; Erdal, Mehmet Emin; Bayazıt, Hüseyin; Kandemir, Sultan Basmacı; Ay, Mustafa; Kandemır, Hasan; Ay, Özlem İzci; Çiçek, Erdinç; Selek, Salih; Taşdelen, Bahar

doi:10.9758/cpn.2016.14.3.256

Cited by 35 publications

(22 citation statements)

References 30 publications

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“…This discrepancy may be caused by different stimulations in different species. Regarding of schizophrenia, previous study indicated that schizophrenia patients showed statistically significant upregulation of miR-9 in the peripheral blood [46]. However, Topol et al demonstrated that the level of miR-9 was decreased in the subset of schizophrenia-patient-derived neural progenitor cells [47].…”

Section: Discussionmentioning

confidence: 99%

CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination

et al. 2018

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Circular RNAs (circRNAs), highly expressed in the central nervous system, are involved in various regulatory processes and implicated in some pathophysiology. However, the potential role of circRNAs in psychiatric diseases, particularly major depressive disorder (MDD), remains largely unknown. Here, we demonstrated that circular RNA DYM (circDYM) levels were significantly decreased both in the peripheral blood of patients with MDD and in the two depressive-like mouse models: the chronic unpredictable stress (CUS) and lipopolysaccharide (LPS) models. Restoration of circDYM expression significantly attenuated depressive-like behavior and inhibited microglial activation induced by CUS or LPS treatment. Further examination indicated that circDYM functions as an endogenous microRNA-9 (miR-9) sponge to inhibit miR-9 activity, which results in a downstream increase of target-HECT domain E3 ubiquitin protein ligase 1 (HECTD1) expression, an increase of HSP90 ubiquitination, and a consequent decrease of microglial activation. Taken together, the results of our study demonstrate the involvement of circDYM and its coupling mechanism in depression, providing translational evidence that circDYM may be a novel therapeutic target for depression.

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Section: Discussionmentioning

confidence: 99%

CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination

et al. 2018

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“…In recent years, it has been accepted that the biological basis of mental conditions also entails genetics, impairment in biochemical neurotransmission and receptor functions, and oxidative stress/antioxidant balance. 6 – 8) Furthermore, neuro-inflammatory processes play a significant role in both the etiology and progression of psychiatric disorders. 9 – 11) Evaluation of the relationship between opioid dependence and neuroinflammation indicated differences in the serum levels of cytokines like interleukin-1β (IL-1β), IL-2, IL-4, IL-6, IL-8, interferon gamma (IFN-γ) and tumor necrosis factor alfa (TNF-α).…”

Section: Introductionmentioning

confidence: 99%

Increased Neutrophil-lymphocyte and Platelet-lymphocyte Ratios in Male Heroin Addicts: A Prospective Controlled Study

Çiçek

Demırel²,

Çiçek³

et al. 2018

Clin Psychopharmacol Neurosci

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ObjectiveThe neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are markers that can determine the presence of systemic inflammatory response. In this study, we examined the NLR and PLR levels in patients with heroin dependence compared to healthy controls.MethodsThe study sample included 90 male patients with heroin dependence aged 18 to 45 years and 60 healthy subjects who had similar socio-demographic characteristics as the patient group. The diagnoses of heroin dependence and other Axis I psychiatric disorders in the patient and control groups were screened with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (SCID-I). The extent of heroin addiction was assessed with the Addiction Severity Index (ASI).ResultsThe mean NLR and PLR levels of patients with heroin dependence were significantly higher than the control subjects (p=0.031 and p<0.001, respectively). Positive correlations were found between NLR, PLR and duration of the disorder.ConclusionOur results indicate that inflammatory processes may play a role in the pathophysiology of heroin dependence.

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“…The microarray data and RT-qPCR data identified miR-125a to be upregulated in the rats with MCAO; these results are consistent with the hypothesis that some miRNAs can be differentially expressed in a stroke-affected brain. Previous studies have indicated that miR-125a is expressed or enriched in multiple myeloma ( 39 , 40 ), psychiatric disorders ( 41 ) and cerebrovascular diseases ( 42 ). miR-125a has been shown to play a role in cancer development and metastasis, and to be involved in neurodegenerative diseases ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-125a-3p is involved in early behavioral disorders in stroke-afflicted rats through the regulation of Cadm2

Liu

Ren

et al. 2017

Int J Mol Med

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Ischemic strokes carry a significant risk of mortality and recurrent vascular events. Recent studies suggest that changes in microRNAs (miRNAs or miRs) may affect the development of the stroke. However, few studies have investigated the role of miRNAs in behavioral disorder in early stroke. In the present study, animal models of middle cerebral artery occlusion (MCAO) are used, as well as a cell model of neurite outgrowth to further investigate the role of miRNAs in targeting synapse-associated proteins expression in early stroke. The authors used miRNA expression microarrays on RNA extracted from the cortex tissue samples from the rats of MCAO and control rats. Reverse transcription-quantitative polymerase chain reaction was conducted to verify the candidate miRNAs discovered by microarray analysis. Data indicated that miR-125a was significantly increased in the cortex of the model of MCAO, which were concomitant with that rats of MCAO at the same age displayed significant behavioral deficits. Bioinformatics analysis predicted the cell adhesion molecule 2 (Cadm2, mRNA) neurite outgrowth-associated protein is targeted by miR-125a. Overexpression of miR-125a reduced the level of Cadm2 expression in PC12 cell injury induced by free-serum. In contrast, inhibition of miR-125a using miR-125a inhibitors significantly resulted in higher levels of Cadm2 expression. In conclusion, miR-125a is involved in the behavioral disorder of animal models of MCAO by regulation of Cadm2.

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Investigation of Dysregulation of Several MicroRNAs in Peripheral Blood of Schizophrenia Patients

Cited by 35 publications

References 30 publications

CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination

CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination

Increased Neutrophil-lymphocyte and Platelet-lymphocyte Ratios in Male Heroin Addicts: A Prospective Controlled Study

MicroRNA-125a-3p is involved in early behavioral disorders in stroke-afflicted rats through the regulation of Cadm2

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