Thiol Disulfide Homeostasis in Schizophrenic Patients Using Atypical Antipsychotic Drugs

Doğan, Halef Okan; Erşan, Etem Erdal; Aydın, Hüseyin; Erdoğan, Serpil; Erşan, Serpil; Alışık, Murat; Bakır, Sevtap; Erel, Özcan; Koç, Derya

doi:10.9758/cpn.2018.16.1.39

Cited by 9 publications

(5 citation statements)

References 39 publications

(38 reference statements)

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“…36 Similarly, other studies newly introduced the effect of antipsychotic drugs on biomarkers in schizophrenia patients. [37][38][39] The effect of olanzapine on homocysteine levels post-treatment at the 10th week in schizophrenia patients and their clinical relation using BPRS was that olanzapine significantly decreases homocysteine levels and clinically improved symptoms of schizophrenia. But this effect was not compared with a standard drug.…”

Section: Discussionmentioning

confidence: 99%

Homocysteine Levels and Clinical Outcomes in Schizophrenia—A Pilot Randomized Controlled Trial

Vedam

Ghanta

Kantipudi

et al. 2022

Journal of Pharmacology and Pharmacotherapeutics

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Background: There is an increasing need for proactive and individualized responses to various diseases in today’s progressive health-care fraternity. Accordingly, the approach to schizophrenia patients encompasses novel developments in the area of personalized medicine. Antipsychotic drugs in clinical practice necessitate biomarkers for the prediction of treatment outcomes and monitoring to ensure an appropriate choice of duration of chronic therapies. Hence, we studied the relation between homocysteine levels in peripheral blood and the effectiveness as well as the safety of haloperidol and olanzapine in schizophrenia treatment. Materials and Methods: A prospective randomized parallel-group open-label interventional clinical trial was conducted on 40 mild to moderate schizophrenia patients. To compare the efficacy of olanzapine and haloperidol Brief Psychiatric Rating Scale (BPRS) score was used. Homocysteine levels of peripheral blood and Abnormal Involuntary Movement Scale scores were evaluated. Results: BPRS score improved in both groups on day 14 and day 28. But significantly more with olanzapine ( P value =.001). The olanzapine group showed a higher reduction (13.91±0.47 to 9.74±0.5) in homocysteine levels than the haloperidol group. Also, the BPRS scores negatively correlated ( r = –0.66) to homocysteine levels. Conclusion: Therefore, our study shows that peripheral blood homocysteine levels can be used to predict and assess the treatment outcome in schizophrenia patients. Biomarker driven approach in schizophrenia will allow the patients to be treated promptly with the right drug. In this light, personalized treatment holds great potential in the future.

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Section: Discussionmentioning

confidence: 99%

Homocysteine Levels and Clinical Outcomes in Schizophrenia—A Pilot Randomized Controlled Trial

Vedam

Ghanta

Kantipudi

et al. 2022

Journal of Pharmacology and Pharmacotherapeutics

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“…Many studies have shown an increase in oxidative stress in patients with SCZ. 29,30 Some scholars have found that with accumulation of oxides, the resulting catecholamine o-quinones can cause dopaminergic neuron degeneration. 31 GSTs exert their antioxidant function by degrading the oxidative metabolite of catecholamine o-quinones.…”

Section: Discussionmentioning

confidence: 99%

<p>Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population</p>

Yan¹,

Duan²,

Fu³

et al. 2020

NDT

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Background: Glutathione S-transferase (GST) is an important antioxidant enzyme in the body. The weakening of the antioxidant system causes damage to the cells and tissues that make up the organism, adversely affects the function of the nervous system, and ultimately leads to schizophrenia (SCZ). Previous studies have yielded inconsistent results across different ethnic populations. Purpose: This case-control study was carried out to investigate whether genetic polymorphisms in GST could be associated with SCZ in the Chinese Han population. Patients and Methods: A total of 794 participants, including 379 SCZ patients (case group) and 415 healthy individuals (control group), were genotyped by polymerase chain reaction-restriction fragment length for polymorphisms in GST genes. Results: The study found that the frequency of the GSTM1 null genotype was higher in case group than control group (p=0.003). The frequency of the GSTM1 and GSTT1 double null genotype was also higher in case group than control group (p=0.008). Conclusion: We conclude that the GSTM1 null genotype and the GSTM1 and GSTT1 double null genotype may be related to the onset of SCZ in Chinese Han population.

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“…Antipsychotics, mood stabilizers, and antidepressants can also affect the oxidation process. A recent study examining the level of thiol-disulfide in patients with schizophrenia patients shows that the oxidative processes are influenced by atypical antipsychotic treatment [34]. Mood stabilizer drugs may reduce the level of lipid peroxidation [35].…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, it was also argued that atypical antipsychotic drugs might affect oxidative status by increasing the antioxidant levels and decreasing the oxidative stress [ 36 - 39 ]. A recent study showed that compared to controls, SH and ToSH levels were higher in patients with schizophrenia, who were on atypical antipsychotic drugs [ 34 ]. In our study, although the majority of the patients with BD were using antipsychotics, there was a shift toward the oxidative stress in the TDH in these patients.…”

Section: Discussionmentioning

confidence: 99%

Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression

Erzın

Özkaya

Topçuoğlu

et al. 2020

Clin Psychopharmacol Neurosci

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Objective: Bipolar disorder and unipolar depressive disorder are complex phenotypes. There appear to be phenotypical, mechanistic, and therapeutic differences between bipolar depression (BD) and unipolar depression (UD). There is a need for understanding the underlying biological variation between these clinical entities. The role of oxidative processes underlying bipolar disorder and depression has been demonstrated. Thiol-disulfide homeostasis (TDH) is a recent oxidative stress marker. In this study, we aimed to inspect patients with bipolar depression and unipolar depression in terms of thiol-disulfide balance and to compare them with healthy controls. Methods: Patients admitted to the outpatient clinic of Ankara Numune Training and Research Hospital and diagnosed either as a depressive episode with bipolar disorder (n = 37) or unipolar depression (n = 24) according to DSM-5 criteria, along with healthy controls (HC) (n = 50), were included in the study. Native thiol, total thiol, and disulfide levels were compared across the groups. Results: In comparison to HC, both BD and UD groups had higher disulfide levels, disulfide/native thiol ratio, and disulfide/total thiol ratio. No significant differences between BD and UD were detected in terms of disulfide level, disulfide/native thiol ratio, and disulfide/total thiol ratio. Conclusion: Increased levels of disulfide, native thiol, and disulfide/total thiol ratios compared to healthy controls in both UD and BD groups may be indicative of the presence of oxidative damage in these two clinical conditions. To clarify the role of oxidative stress in the pathophysiology of depressive disorders and investigate TDH, longitudinal studies in patients with medication-free UD and BD are required.

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Thiol Disulfide Homeostasis in Schizophrenic Patients Using Atypical Antipsychotic Drugs

Cited by 9 publications

References 39 publications

Homocysteine Levels and Clinical Outcomes in Schizophrenia—A Pilot Randomized Controlled Trial

Homocysteine Levels and Clinical Outcomes in Schizophrenia—A Pilot Randomized Controlled Trial

<p>Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population</p>

Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression

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