Effect of poly(ethylene oxide) with different molecular weights on the electrospinnability of sodium alginate

Nie, Huarong; He, Aihua; Wu, Wanling; Zheng, Jie; Xu, Shanshan; Li, Junxing; Han, Charles C.

doi:10.1016/j.polymer.2009.07.043

Cited by 82 publications

(63 citation statements)

References 29 publications

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“…The physical properties of the electrospun solution were directly related to the ability to form uniform nanofibers [45]. The flexibility and toughness of PVA is good, so it is often used to improve the physical properties through mixing with other materials [37].…”

Section: Electrospinning Of Aad/pva Blend Solutionsmentioning

confidence: 99%

Synthesis of amphiphilic alginate derivatives and electrospinning blend nanofibers: a novel hydrophobic drug carrier

et al. 2015

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As a kind of novel hydrophobic drug carrier materials, the drug-loaded nanofibers were successfully fabricated using amphiphilic alginate derivative (AAD) and poly (vinyl alcohol) (PVA) by electrospinning method. The AAD was synthesized by amide linkage attachment of octylamine onto the carboxylic group of alginate, which was characterized by the means of elemental analysis, FT-IR spectrometer, 1 H NMR spectrometer and fluorescence measurement. Experimental results showed the amidation of alginate was successful, in which the degree of modification was 0.27 and the critical aggregation concentration in 0.15 mol/L aqueous NaCl solution was 0.43 mg/mL. The octyl groups of AAD could effectively make alginate chains flexible and enhance chain entanglements through the hydrophobic interactions between octyl groups. In contrast to sodium alginate (SA)/ PVA blend solutions, AAD/PVA blend solutions showed more excellent electrospinnability. Additionally, the different volume ratios of SA or AAD to PVA played an important role in the formation and morphology of the electrospun blend nanofibers. Although the amidation of alginate could not fundamentally alter the spinnability of alginate, the content of alginate in the blend nanofibers was appropriately increased. The new generated drug-loaded AAD/PVA (20/80) blend nanofibers exhibited relatively continuous and uniform nanofibers with the average diameter of 191.72 nm. Compared to the drug-loaded SA/PVA (20/80) blend nanofibers, the drug-loaded AAD/PVA (20/80) blend nanofibers presented a sustained release performance with the slow release of about 76 % k-cyhalothrin during the initial period of 10 h.

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Section: Electrospinning Of Aad/pva Blend Solutionsmentioning

confidence: 99%

Synthesis of amphiphilic alginate derivatives and electrospinning blend nanofibers: a novel hydrophobic drug carrier

et al. 2015

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“…Alginate is a renewable, biocompatible polysaccharide derived from brown seaweed, containing guluronic (G), and mannuronic (M) blocks. Although unable to be electrospun into nanofibers on its own due to the lack of chain entanglement, water‐soluble linear polymers such as polyethylene oxide (PEO) have often been added to an alginate solution to aid electrospinning, together with surfactants and cosolvents . The carboxyl groups in G blocks in alginate are capable of crosslinking in the presence of divalent ions such as calcium and barium, thereby reducing the dissolution rate of electrospun alginate nanofibers.…”

Section: Introductionmentioning

confidence: 99%

Postelectrospinning modifications for alginate nanofiber‐based wound dressings

et al. 2013

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Alginate nanofibers have been attractive for potential tissue regeneration applications due to a combination of their moisture retention ability and large surface area available in a nonwoven nanofiber form. This study aims to address several challenges in alginate nanofiber application, including the lack of structural stability in aqueous environment and limited cell attachment as compared to commercial wound dressings, via examining crosslinking techniques. In addition to the commonly performed divalent ion crosslinking, a glutaraldehyde double-crosslinking step and polylysine addition were applied to an electrospun alginate nanofiber nonwoven mat. With optimization of the electrospinning solution, nanofiber morphology was maintained after the two-stage crosslinking process. Extensibility of the nanofiber mat reduced after the crosslinking process. However, both aqueous stability and cell attachment improved after the postspinning modifications, as shown through degradation tests in phosphate buffered saline solutions and fibroblast cell culture studies, respectively.

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“…The SA (2%) and PVA (12%) solutions were prepared by dissolving 2 g of SA and 12 g of PVA separately in 100 mL of distilled water (Nie et al, 2009). PVA/SA solutions containing various volume ratios (8:2, 7:3, 6:4, 5:5 and 4:6) of 12% PVA and 2% SA were prepared and the conductivity of the solutions was determined so that the optimal volume ratio could be found.…”

Section: Preparation Of Mh/pva/sa Nanofibersmentioning

confidence: 99%

A novel electrospun membrane based on moxifloxacin hydrochloride/poly(vinyl alcohol)/sodium alginate for antibacterial wound dressings in practical application

et al. 2014

Drug Delivery

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College of Pharmacy, Chongqing Medical University, Chongqing, P. R. China AbstractThis study reports on the performance of sodium alginate (SA)/poly(vinyl alcohol) (PVA)/ moxifloxacin hydrochloride (MH) nanofibrous membranes (NFM) capable of providing antibacterial agent delivery for wound-dressing applications. The aim of this work was to prepare antibacterial NFM with good permeability properties by employing PVA and SA as carriers. A group of 12% PVA/2% SA solutions blended in various ratios (8:2, 7:3, 6:4, 5:5 and 4:6, v/v) and containing 0.5, 1, 2 or 4 wt% MH were studied for electrospinning into nanoscale fibermats. The optimum ratio found to form smooth fibers with uniform fibrous features was 6:4. The drug release behavior of the electrospun, the antibacterial effects on Pseudomonas aeruginosa and Staphylococcus aureus and the animal wound dressing capabilities were also investigated. As much as 80% of the MH was released from the electrospun after 10 h of incubation at 37 C. In addition, the NFM with 0.5 MH exhibited less activity, whereas those with higher concentrations of MH exhibited greater antibacterial effect. Furthermore, the MH-loaded electrospun accelerated the rate of wound dressing compared to other groups. The results of the in vitro and in vivo experiments suggest that MH/PVA/SA nanofibers might be an interesting bioactive wound dressing for clinical applications.

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Effect of poly(ethylene oxide) with different molecular weights on the electrospinnability of sodium alginate

Cited by 82 publications

References 29 publications

Synthesis of amphiphilic alginate derivatives and electrospinning blend nanofibers: a novel hydrophobic drug carrier

Synthesis of amphiphilic alginate derivatives and electrospinning blend nanofibers: a novel hydrophobic drug carrier

Postelectrospinning modifications for alginate nanofiber‐based wound dressings

A novel electrospun membrane based on moxifloxacin hydrochloride/poly(vinyl alcohol)/sodium alginate for antibacterial wound dressings in practical application

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