Effect of platelet-rich plasma in the treatment of periodontal intrabony defects in humans

Ouyang, Xiangying; Qiao, Jing

doi:10.1097/00029330-200609020-00003

Cited by 48 publications

(51 citation statements)

References 39 publications

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“…The full text of the remaining 21 papers was then searched. For 1 study, the full text was not obtained [12], so the final pool was 20 studies. Out of these, 3 papers were further rejected for the following reasons: two studies did not provide a control group [13, 14] and one was not a fully RCT [15].…”

Section: Resultsmentioning

confidence: 99%

Adjunctive Platelet-Rich Plasma (PRP) in Infrabony Regenerative Treatment: A Systematic Review and RCT’s Meta-Analysis

Saleem

Pisani

Zahid

et al. 2018

Stem Cells International

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Background and Objective The purpose of this study was to highlight the clinical performance of platelet-rich plasma (PRP) used as an adjunctive tool for regeneration in infrabony periodontal defects using different biomaterials or performing different surgical flap approaches. Comparative evaluation of main clinical outcomes as probing pocket depth reduction, clinical attachment gain, and recession reduction with and without the use of PRP has been analysed. Materials and Methods According to the focused question, an electronic and hand searching has been performed up to December 2016. From a batch of 73 articles, the selection strategy and Jadad quality assessment led us to include 15 studies for the meta-analysis. Results Despite the high heterogeneity found and the lack of complete data regarding the selected clinical outcomes, a comparative analysis has been possible by the categorization of used biomaterials and surgical flap approaches. This method led us to observe the best performance of grafts with the use of adjunctive PRP in CAL gain and PPD reduction. No difference has been outlined with a specific surgical flap. Conclusions Although PRP is considered a cheap and patient's derived growth factor, the not conclusive data reported would suggest that its use in addition to bone substitutes could be of some clinical benefit in the regenerative treatment of infrabony defects. Clinical Relevance This systematic review was intended to sort out the huge controversial debate in the field about the possible use of PRP in regenerative surgery in infrabony defect. The clinical relevance of using blood-borne growth factors to conventional procedures is effective as these could determine a better performance and outcomes despite the surgical approach adopted and limit the use of additional biomaterials for the blood clot stabilization.

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Section: Resultsmentioning

confidence: 99%

Adjunctive Platelet-Rich Plasma (PRP) in Infrabony Regenerative Treatment: A Systematic Review and RCT’s Meta-Analysis

Saleem

Pisani

Zahid

et al. 2018

Stem Cells International

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“…A randomized, split mouth, double-masked clinical study [36] showed that the addition of PRP to a bovine derived xenograft to treat human intrabony defects significantly improved the clinical outcome. Another recent study evaluated the effect of PRP in the treatment of periodontal intrabony defects in humans [37] and showed that the combination of PRP with bovine porous bone mineral led to significantly favorable clinical improvements. The unfavorable results seen in other studies [32,33] may be due to the incompatible combination of PRP with the chosen biomaterial or to the fact that the concentration of platelets in PRP may vary according to the procedure used for its preparation [32].…”

Section: Discussionmentioning

confidence: 99%

Calcium Sulfate and Platelet-Rich Plasma make a novel osteoinductive biomaterial for bone regeneration

Intini

Andreana

Intini³

et al. 2007

J Transl Med

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BackgroundWith the present study we introduce a novel and simple biomaterial able to induce regeneration of bone. We theorized that nourishing a bone defect with calcium and with a large amount of activated platelets may initiate a series of biological processes that culminate in bone regeneration. Thus, we engineered CS-Platelet, a biomaterial based on the combination of Calcium Sulfate and Platelet-Rich Plasma in which Calcium Sulfate also acts as an activator of the platelets, therefore avoiding the need to activate the platelets with an agonist.MethodsFirst, we tested CS-Platelet in heterotopic (muscle) and orthotopic (bone) bone regeneration bioassays. We then utilized CS-Platelet in a variety of dental and craniofacial clinical cases, where regeneration of bone was needed.ResultsThe heterotopic bioassay showed formation of bone within the muscular tissue at the site of the implantation of CS-Platelet. Results of a quantitative orthotopic bioassay based on the rat calvaria critical size defect showed that only CS-Platelet and recombinant human BMP2 were able to induce a significant regeneration of bone. A non-human primate orthotopic bioassay also showed that CS-Platelet is completely resorbable. In all human clinical cases where CS-Platelet was used, a complete bone repair was achieved.ConclusionThis study showed that CS-Platelet is a novel biomaterial able to induce formation of bone in heterotopic and orthotopic sites, in orthotopic critical size bone defects, and in various clinical situations. The discovery of CS-Platelet may represent a cost-effective breakthrough in bone regenerative therapy and an alternative or an adjuvant to the current treatments.

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“…While no substantial evidence supports the routine application of PRP products in daily clinical practice, there is still great interest concerning its use in combination with bone grafts as a potential modality for periodontal regeneration and there do have positive outcomes in several crosssectional investigations [69,71]. For example, the treatment of deep intra-bony periodontal defects with a combination of PRP and bone grafts has led to a significantly favorable clinical and radiographic improvement [73,74]. It seems much more can be done to improve PRP technology itself as well as to standardize its application.…”

Section: The Use Of Prp In Periodontal Therapymentioning

confidence: 99%

“…However, published data on PRP-assisted grafting reports variable clinical outcomes, regardless of whether or not the study authors are in support of the PRP concept [69,71,74,75]. Sound biological rationale and a multitude of basic science research supports the use of PRP in promoting soft tissue healing, although evidence of its role in enhancing periodontal applications, especially root coverage, is limited.…”

Section: The Use Of Prp In Periodontal Therapymentioning

confidence: 99%

A review on endogenous regenerative technology in periodontal regenerative medicine

et al. 2010

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Effect of platelet-rich plasma in the treatment of periodontal intrabony defects in humans

Cited by 48 publications

References 39 publications

Adjunctive Platelet-Rich Plasma (PRP) in Infrabony Regenerative Treatment: A Systematic Review and RCT’s Meta-Analysis

Adjunctive Platelet-Rich Plasma (PRP) in Infrabony Regenerative Treatment: A Systematic Review and RCT’s Meta-Analysis

Calcium Sulfate and Platelet-Rich Plasma make a novel osteoinductive biomaterial for bone regeneration

A review on endogenous regenerative technology in periodontal regenerative medicine

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