A review on endogenous regenerative technology in periodontal regenerative medicine

Chen, Fa‐Ming; Zhang, Jing; Zhang, Min; An, Yu; Wu, Zhifen

doi:10.1016/j.biomaterials.2010.07.019

Cited by 331 publications

(295 citation statements)

References 303 publications

(441 reference statements)

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“…46,47 As a result, many regenerative design strategies have focused on isolating and concentrating portions of human blood such as platelets and plasma (e.g., platelet-rich plasma [PRP]) or pro-coagulation molecules (e.g., fibrin sealants) to enhance endogenous healing responses. [48][49][50][51][52][53][54] It remains to be seen whether a scaffold with only inflammation-related chemical and mechanical cues can elicit enough of an EC ossification response to heal critical-sized bone defects.…”

Section: Coupling In Vivo Developmental Engineering With Native Ecm Bmentioning

confidence: 99%

Endochondral Ossification for Enhancing Bone Regeneration: Converging Native Extracellular Matrix Biomaterials and Developmental Engineering In Vivo

Dennis

Berkland

Bonewald

et al. 2015

Tissue Engineering Part B: Reviews

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Section: Coupling In Vivo Developmental Engineering With Native Ecm Bmentioning

confidence: 99%

Endochondral Ossification for Enhancing Bone Regeneration: Converging Native Extracellular Matrix Biomaterials and Developmental Engineering In Vivo

Dennis

Berkland

Bonewald

et al. 2015

Tissue Engineering Part B: Reviews

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“…However, these treatment modalities are expensive due to the high cost of bone-harvesting procedures and are associated with donor site morbidity, hematomas, inflammation, and pain. 1,2 Tissue regeneration using mesenchymal stem cells (MSCs) presents several advantages over grafts, including high-quality regeneration of damaged tissues without the formation of fibrous tissue, no donor-site harvesting, and low risk of disease transmission or autoimmune rejection due to the immunoregulatory capacity of MSCs. 3 It is well known that MSCs reside in a wide spectrum of postnatal tissue types, including the dental and orofacial tissues.…”

Section: Introductionmentioning

confidence: 99%

Bone Regeneration Potential of Stem Cells Derived from Periodontal Ligament or Gingival Tissue Sources Encapsulated in RGD-Modified Alginate Scaffold

Moshaverinia

Chen

et al. 2013

Tissue Engineering Part A

117

131

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Mesenchymal stem cells (MSCs) provide an advantageous alternative therapeutic option for bone regeneration in comparison to current treatment modalities. However, delivering MSCs to the defect site while maintaining a high MSC survival rate is still a critical challenge in MSC-mediated bone regeneration. Here, we tested the bone regeneration capacity of periodontal ligament stem cells (PDLSCs) and gingival mesenchymal stem cells (GMSCs) encapsulated in a novel RGD-(arginine-glycine-aspartic acid tripeptide) coupled alginate microencapsulation system in vitro and in vivo. Five-millimeter-diameter critical-size calvarial defects were created in immunocompromised mice and PDLSCs and GMSCs encapsulated in RGD-modified alginate microspheres were transplanted into the defect sites. New bone formation was assessed using microcomputed tomography and histological analyses 8 weeks after transplantation. Results confirmed that our microencapsulation system significantly enhanced MSC viability and osteogenic differentiation in vitro compared with non-RGD-containing alginate hydrogel microspheres with larger diameters. Results confirmed that PDLSCs were able to repair the calvarial defects by promoting the formation of mineralized tissue, while GMSCs showed significantly lower osteogenic differentiation capability. Further, results revealed that RGD-coupled alginate scaffold facilitated the differentiation of oral MSCs toward an osteoblast lineage in vitro and in vivo, as assessed by expression of osteogenic markers Runx2, ALP, and osteocalcin. In conclusion, these results for the first time demonstrated that MSCs derived from orofacial tissue encapsulated in RGD-modified alginate scaffold show promise for craniofacial bone regeneration. This treatment modality has many potential dental and orthopedic applications.

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“…24 Ideally, the scaffold should mimic the cells' microenvironment, giving the required structural signals, adhesion molecules, and pore size for homing, differentiation, and phenotypic acquisition, 25 while allowing cell-cell and cellmatrix interactions. 26 Even minute differences in the scaffold geometry, pore size, elasticity, mechanical properties, chemical composition, and degradation rate can greatly influence the cells regenerative behavior in vivo. 23,27 In the analyzed studies, the scaffold/carrier selection was closely related to the design of the experimental defect, with mineralized b-TCP used for capping of pulp defects, while those studies with partial to complete pulpal removal/amputation used cell pellets in the absence of a scaffold or applied cells on different collagen carriers to conform to the respective pulp chamber form.…”

Section: Discussionmentioning

confidence: 99%

Stem Cell Transplantation for Pulpal Regeneration: A Systematic Review

El‐Sayed

Jakusz

Jochens³

et al. 2015

Tissue Engineering Part B: Reviews

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For treating pulpal pathological conditions, pulpal regeneration through transplanted stem/progenitor cells might be an alternative to conventional root canal treatment. A number of animal studies demonstrated beneficial effects of stem/progenitor cell transplantation for pulp-dentin complex regeneration, that is, pulpal tissue, neural, vascular, and dentinal regeneration. We systematically reviewed animal studies investigating stem/progenitor cell-mediated pulp-dentin complex regeneration. Studies quantitatively comparing pulp-dentin complex regeneration after transplantation of stem/progenitor cells versus no stem/progenitor cell transplantation controls in intraoral in vivo teeth animal models were analyzed. The following outcomes were investigated: regenerated pulp area per root canal total area, capillaries per total surface, regenerated dentinal area per total defect area, and nerves per total surface. PubMed and EMBASE were screened for studies published until July 2014. Crossreferencing and hand searching were used to identify further articles. Standardized mean differences (SMD) and 95% confidence intervals (95% CI) were calculated using random-effects meta-analysis. To assess possible bias, SYRCLE's risk of bias tool for animal studies was used. From 1364 screened articles, five studies (representing 64 animals) were included in the quantitative analysis. Risk of bias of all studies was high. Stem/progenitor celltransplanted pulps showed significantly larger regenerated pulp area per root canal total area (SMD [95% CI]: 2.28 [0.35-4.21]) and regenerated dentin area per root canal total area ]) compared with no stem/progenitor cell transplantation controls. Only one study reported on capillaries per or nerves per total surface and found both significantly increased in stem/progenitor cell-transplanted pulps compared with controls. Stem/progenitor cell transplantation seems to enhance pulp-dentin complex regeneration in animal models. Due to limited data quantity and quality, current evidence levels are insufficient for further conclusions.

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A review on endogenous regenerative technology in periodontal regenerative medicine

Cited by 331 publications

References 303 publications

Endochondral Ossification for Enhancing Bone Regeneration: Converging Native Extracellular Matrix Biomaterials and Developmental Engineering In Vivo

Endochondral Ossification for Enhancing Bone Regeneration: Converging Native Extracellular Matrix Biomaterials and Developmental Engineering In Vivo

Bone Regeneration Potential of Stem Cells Derived from Periodontal Ligament or Gingival Tissue Sources Encapsulated in RGD-Modified Alginate Scaffold

Stem Cell Transplantation for Pulpal Regeneration: A Systematic Review

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