Effect of Photobiomodulation on Mesenchymal Stem Cells

Fekrazad, Reza; Asefi, Sohrab; Allahdadi, Mahdi; Kalhori, Katayoun Am

doi:10.1089/pho.2015.4029

Cited by 70 publications

(37 citation statements)

References 74 publications

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“…64,65 Aside from the effects on mitochondria, PBM is also known to induce proliferation and migration of stem cells. 32,[66][67][68][69] It has been suggested that through this induction, PBM can mobilize stem cells that home specifically to damaged tissue to aid in repair. For example, in animal models, PBM applied to the tibia results in migration of stem cells and mitigation of damage in models of myocardial infarction [70][71][72] and Alzheimer's disease.…”

Section: Photobiomodulationmentioning

confidence: 99%

“Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?

Liebert

Bicknell

Johnstone

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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Section: Photobiomodulationmentioning

confidence: 99%

“Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?

Liebert

Bicknell

Johnstone

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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“…More recently, Fekrazad et al [23] also published a review on the effect of PBMT on MSCs, confirming the positive effects of PBMT. Moreover, the authors found the most appropriate doses (0.7-4 J cm −2 ) and wavelengths (600 to 700 nm) to increase cell proliferation.…”

Section: Pbmt Effect On Different Types Of Cellsmentioning

confidence: 83%

Effects of photobiomodulation therapy in dentoalveolar-derived mesenchymal stem cells: a review of literature

et al. 2017

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This review aims to present and discuss the published data on the application of photobiomodulation therapy (PBMT) on cultured cells, including dentoalveolar-derived mesenchymal stem cells (ddMSCs). The knowledge of the effects of PBMT on ddMSCs is of importance for future application in tissue engineering approaches aiming to regenerate missing dental tissues, among others. The tissue engineering, which is based on the triad stem cells, growth factors, and scaffolds, presents shortcomings that could be circumvented by the effects of the PBMT. Thus, our research group has proposed the PBMT as a fourth element of tissue engineering. This proposition is based on the published data on the effects of PBMT on different cell types, including ddMSCs. Future perspectives on PBMT and ddMSCs will be presented showing translational studies of tissue regeneration induced by PBMT. The experience of our research group supported by other studies of the literature shows the beneficial effects of PBMT. Moreover, this review will show that PBMT on ddMSCs and tissue regeneration is still a huge field for future investigations not only in vitro but also in vivo.

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“…Photomedicine encompasses the study and application of lights in diseases and health. Photobiomodulation (PBM) therapy is based on the exposure of biological tissues to low‐level laser light (coherent light) or light‐emitting diodes (LEDs; noncoherent light), leading to modulation of cellular functions, such as proliferation and migration, which result in tissue regeneration . Most tissues in adult humans have a potent pool of resident stem and progenitor cells.…”

Section: Introductionmentioning

confidence: 99%

“…Photobiomodulation (PBM) therapy is based on the exposure of biological tissues to low-level laser light (coherent light) or light-emitting diodes (LEDs; noncoherent light), leading to modulation of cellular functions, such as proliferation and migration, which result in tissue regeneration. [2] Most tissues in adult humans have a potent pool of resident stem and progenitor cells. These cells play a pivotal role in routine physiological turnover during tissue-organ maintenance and they contribute to the repair of tissue injury.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of repigmentation induced by photobiomodulation therapy in vitiligo

Lan

2019

Experimental Dermatology

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Photobiomodulation (PBM) therapy is based on the exposure of biological tissues to low‐level laser light (coherent light) or light‐emitting diodes (LEDs; noncoherent light), leading to the modulation of cellular functions, such as proliferation and migration, which result in tissue regeneration. PBM therapy has important clinical applications in regenerative medicine. Vitiligo is an acquired depigmentary disorder resulting from disappearance of functional melanocytes in the involved skin. Vitiligo repigmentation depends on available melanocytes derived from (a) melanocyte stem cells located in the bulge area of hair follicles and (b) the epidermis at the lesional borders, which contains a pool of functional melanocytes. Since follicular melanoblasts (MBs) are derived from the melanocyte stem cells residing at the bulge area of hair follicle, the process of vitiligo repigmentation presents a research model for studying the regenerative effect of PBM therapy. Previous reports have shown favourable response for treatment of vitiligo with a low‐energy helium‐neon (He‐Ne) laser. This review focuses on the molecular events that took place during the repigmentation process of vitiligo triggered by He‐Ne laser (632.8 nm, red light). Monochromatic radiation in the visible and infrared A (IRA) range sustains matrix metalloproteinase (MMP), improves mitochondrial function, and increases adenosine triphosphate (ATP) synthesis and O2 consumption, which lead to cellular regenerative pathways. Cytochrome c oxidase in the mitochondria was reported to be the photoacceptor upon which He‐Ne laser exerts its effects. Mitochondrial retrograde signalling is responsible for the cellular events by red light. This review shows that He‐Ne laser initiated mitochondrial retrograde signalling via a Ca2+‐dependent cascade. The impact on cytochrome c oxidase within the mitochondria, an event that results in activation of CREB (cyclic‐AMP response element binding protein)‐related cascade, is responsible for the He‐Ne laser promoting functional development at different stages of MBs and boosting functional melanocytes. He‐Ne laser irradiation induced (a) melanocyte stem cell differentiation; (b) immature outer root sheath MB migration; (c) differentiated outer root sheath MB melanogenesis and migration; and (d) perilesional melanocyte migration and proliferation. These photobiomodulation effects result in perifollocular and marginal repigmentation in vitiligo.

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Effect of Photobiomodulation on Mesenchymal Stem Cells

Cited by 70 publications

References 74 publications

“Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?

“Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?

Effects of photobiomodulation therapy in dentoalveolar-derived mesenchymal stem cells: a review of literature

Mechanisms of repigmentation induced by photobiomodulation therapy in vitiligo

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