Effect of pheniramine maleate on reperfusion injury in brain tissue

Abstract

BackgroundThe aim of this study was to investigate the protective effects of methylprednisolone (Pn), which is a potent anti-inflammatory agent, and pheniramine maleate (Ph), which is an antihistaminic with some anti-inflammatory effects, on reperfusion injury in brain developing after ischemia of the left lower extremity of rats.Material/MethodsTwenty-eight randomly selected male Sprague-Dawley rats were divided into 4 groups: Group 1 was the control group, Group 2 was the sham group (I/R), Rats in Group 3 were subjected to I/R and given Ph, and rats in Group 4 were subjected to I/R and given Pn. A tourniquet was applied at the level of left groin region of subjects in the I/R group after induction of anesthesia. One h of ischemia was performed with no drug administration. In the Ph group, half of a total dose of 10 mg/kg Ph was administered intraperitoneally before ischemia and the remaining half before reperfusion. In the Pn group, subjects received a single dose of 50 mg/kg Pn intraperitoneally at the 30th min of ischemia. Brains of all subjects were removed after 24 h for examination.ResultsMalondialdehyde (MDA) levels of the prefrontal cortex were significantly lower in the Ph group than in the I/R group (p<0.05). Superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzyme activities were found to be significantly higher in the Ph group than in the I/R group (p<0.05). Histological examination demonstrated that Ph had protective effects against I/R injury developing in the brain tissue.ConclusionsPh has a protective effect against ischemia/reperfusion injury created experimentally in rat brains.

Investigation of the antioxidant effects of pheniramine maleate and nebivolol on testicular damage in rats with experimentally induced testis torsion

“…Yürekli et al 18 illustrated the protective effect of PM by I/R damage in the brain tissue, while Nosalova et al 4 obtained similar results by mesenteric I/R damage. Gökalp et al 1 have detected that PM has a protective effect on the I/R damage of lung tissue through the inhibition of the inflammatory mediators.…”

Renoprotective effect of edaravone in acute limb ischemia/reperfusion injury

“…The SOD activity in the renal tissue was numerically lower in the I/R group than in the control group and numerically higher in the edaravone group than in the I/R group; however, none of these differences were significant. Yurekli et al [20] investigated the effect of pheniramine on brain injury related to lower-extremity I/R, carried out 24-h reperfusion after 1-h ischemia. The SOD activity in the brain tissue was significantly reduced by pheniramine.…”

“…The antioxidant activity of GPx is conferred by its reduction of H 2 O 2 to H 2 O. Yurekli et al [20] showed that the GPx activity in the brain tissue was significantly decreased by I/R and significantly increased by pheniramine. Moreover, the GPx activity in the serum and spinal cord tissue was significantly decreased by I/R and significantly increased by cilostazol.…”

Combined drugs in the treatment of acute respiratory viral infections: a review of research results

“…Так, в одном из исследований было установлено, что фенирамина малеат оказывает защитное дей-ствие против ишемического реперфузионного повреждения в головном мозге крыс [15]. Авторы другого исследования, целью которого было изучение защитного действия метилпреднизолона и фенирамина малеата на реперфузионное повреждение легких, развивающееся после ишемии левой нижней конечности крыс, также заключили, что фенирамина малеат обладает защитным эффектом при ишемическом реперфузионном повреждении легких крыс [16]. В более позднем исследовании на мышиной модели было продемонстрировано, что фенирамина малеат и небиволол обладают антиоксидантным действием против ишемического реперфузионного повреждения, а также способствуют восстановлению тканей [17].…”