Effect of pH on Bactericidal Activities of Calcium Laurate

Morikawa, T.; Yamamoto, Yoshiaki; Nonomura, Yoshiaki

doi:10.5650/jos.ess17280

Cited by 7 publications

(2 citation statements)

References 23 publications

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“…From then, many other studies have proven the bactericidal or bacteriostatic effect of several saturated and unsaturated fatty acids on Gram-positive and Gram-negative bacteria [20,30]. Nowadays, partially driven by the emergence of multidrug-resistant strains, the research on fatty acids and monoglycerides as potential antibacterial agents has gained new attention [30,31,32,33,34,35,36].…”

Section: Resultsmentioning

confidence: 99%

Intracellular Staphylococcus aureus Elicits the Production of Host Very Long-Chain Saturated Fatty Acids with Antimicrobial Activity

et al. 2019

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As a facultative intracellular pathogen, Staphylococcus aureus is able to invade and proliferate within many types of mammalian cells. Intracellular bacterial replication relies on host nutrient supplies and, therefore, cell metabolism is closely bound to intracellular infection. Here, we investigated how S. aureus invasion affects the host membrane-bound fatty acids. We quantified the relative levels of fatty acids and their labelling pattern after intracellular infection by gas chromatography-mass spectrometry (GC-MS). Interestingly, we observed that the levels of three host fatty acids—docosanoic, eicosanoic and palmitic acids—were significantly increased in response to intracellular S. aureus infection. Accordingly, labelling carbon distribution was also affected in infected cells, in comparison to the uninfected control. In addition, treatment of HeLa cells with these three fatty acids showed a cytoprotective role by directly reducing S. aureus growth.

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Section: Resultsmentioning

confidence: 99%

Intracellular Staphylococcus aureus Elicits the Production of Host Very Long-Chain Saturated Fatty Acids with Antimicrobial Activity

et al. 2019

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“…Moran et al (2017) demonstrated that sapienic acid also showed selective antibacterial properties against S. aureus . Furthermore, we have previously reported the antibacterial activities of various FA (Morikawa et al, 2018; Yamamoto et al, 2015a, b, 2017). Palmitoleic acid calcium salt has been demonstrated as an effective bactericide against S. aureus and Propionibacterium acnes , which cause rough skin and acne.…”

Section: Introductionmentioning

confidence: 95%

Selective Antibacterial Activity of Palmitoleic Acid in Emulsions and Other Formulations

Watanabe

Yano

Kawai

et al. 2021

J Surfact & Detergents

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In recent years, the selective antibacterial properties of certain fatty acids (FA) against Staphylococcus aureus have received significant attention. In this study, the antibacterial properties of palmitoleic acid (16:1 FA) in oil (triolein), surfactant (Tween® 60), and water ternary systems were evaluated to demonstrate the effects of the mixed states on the biological activity. The 16:1 FA exhibited selective antibacterial activity against Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 18.8 μg mL−1. In contrast, palmitoleic acid did not display any activity in water‐in‐oil (W/O) emulsions and liquid crystal systems. In some micelle and surfactant‐free oil‐in‐water (O/W) emulsions, the FA showed significant selective antibacterial properties against Staphylococcus aureus. These results suggested that the mixed state of the ternary mixtures affects the antibacterial behavior of FA molecules. The findings of the present study provide a valuable platform for the design of formulations of cosmetics, topical skin products, and skin cleansers.

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Systematic Analysis of Selective Bactericidal Activity of Fatty Acids against <i>Staphylococcus aureus</i> with Minimum Inhibitory Concentration and Minimum Bactericidal Concentration

et al. 2019

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INTRODUCTION Bacteria live on human skin surface and play crucial roles in various skin conditions 1. The microbiota on healthy skin surfaces contains many kinds of bacteria, such as Corynebacterium, Staphylococcus, and Propionibacteriaceae 2 4. Staphylococcal bacteria, including Staphylococcus aureus S. aureus and Staphylococcus epidermidis S. epidermidis are present in the nasal cavity or sebaceous glands. S. aureus causes inflammation of atopic dry skin as well as skin roughness and food poisoning 5, 6. In contrast, S. epidermidis enhances the innate barrier immunity 7 9. Therefore, many dermatologists and cosmetic

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Effect of pH on Bactericidal Activities of Calcium Laurate

Cited by 7 publications

References 23 publications

Intracellular Staphylococcus aureus Elicits the Production of Host Very Long-Chain Saturated Fatty Acids with Antimicrobial Activity

Intracellular Staphylococcus aureus Elicits the Production of Host Very Long-Chain Saturated Fatty Acids with Antimicrobial Activity

Selective Antibacterial Activity of Palmitoleic Acid in Emulsions and Other Formulations

Systematic Analysis of Selective Bactericidal Activity of Fatty Acids against <i>Staphylococcus aureus</i> with Minimum Inhibitory Concentration and Minimum Bactericidal Concentration

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