Selective Antibacterial Activity of Palmitoleic Acid in Emulsions and Other Formulations

Watanabe, T.; Yano, Shigekazu; Kawai, Takeshi; Jinbo, Yuji; Nonomura, Yoshiaki

doi:10.1002/jsde.12529

Cited by 8 publications

(4 citation statements)

References 36 publications

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“…Furthermore, other compounds detected have been reported to have antibacterial properties. They include 2-Hydroxy-5methylbenzaldehyde (Sang and Lin 2019), 1, 2-Benzenedicarboxylic acid (Fadipe et al 2014), Palmitoleic acid (Watanabe et al 2021), Phytol (Pejin et al 2014), Squalene (Nazemi et al 2022) and Dibutyl phthalate (Khatiwora et al 2012). In conclusion, this study revealed the presence of multiple antibiotic-resistant bacteria on fomites of the selected hospitals sampled.…”

Section: Polyalthia Longifoliamentioning

confidence: 99%

Antibacterial activities of Polyalthia longifolia leaf extracts on multiple antibiotic-resistant bacteria isolated from hospital fomites in Akure, Nigeria

BABATUNDE,

OGUNDARE,

ADEBOLU

2023

Nusantara Biosci

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Abstract. Babatunde OJ, Ogundare AO, Adebolu TT. 2023. Antibacterial activities of Polyalthia longifolia leaf extracts on multiple antibiotic-resistant bacteria isolated from hospital fomites in Akure, Nigeria. Nusantara Bioscience 15: 149-160. Polyalthia longifolia (Sonn.), an ornamental plant, is said to be therapeutic while searching for new medications to treat infections caused by multiple Antibiotic-Resistant Bacteria (MAR). This plant's leaves were investigated for prospective antibacterial activity against MAR isolated from fomites in selected hospitals in Akure and their pharmacological properties. Standard microbiological methods were used to isolate and identify bacteria from fomites. Disc diffusion was performed to test their sensitivity to conventional antibiotics and P. longifolia leaf extracts made with ethanol and water. Ciprotab® was used as the control during the antibacterial assay. Therefore, GC-MS analysis was carried out using standard methods to identify the chemicals in the plant leaf extracts. Staphylococcus aureus (29.17%), Streptococcus pyogenes (20.83%), Pseudomonas aeruginosa (14.28%), Escherichia coli (14.28%), Salmonella typhi (12.5%) and Klebsiella pneumoniae (8.33%) were the bacterial species isolated from the fomites sampled in this study. Crude ethanol leaf extract of P. longifolia (100mg/mL) inhibited the growth of these organisms with the greatest effect on P. aeruginosa with a value of 23.83±0.44 mm, which is superior to that medicated by the control antibiotic (ciprofloxacin). The GC-MS analysis of the purified leaf extracts of P. longifolia revealed the presence of bioactive compounds such as n-hexadecanoic acid and phytol, among others. The study revealed that the leaf extracts of P. longifolia can inhibit the growth of the isolated MAR from fomites with an added cidal effect, and the inhibition increase with the increase in concentration and exposure time.

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Section: Polyalthia Longifoliamentioning

confidence: 99%

Antibacterial activities of Polyalthia longifolia leaf extracts on multiple antibiotic-resistant bacteria isolated from hospital fomites in Akure, Nigeria

BABATUNDE,

OGUNDARE,

ADEBOLU

2023

Nusantara Biosci

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“…In mice fed a high-fat diet, the unsaturated palmitoleic acid reduces hepatic gluconeogenesis by decreasing the expression of sirtuin 3 (SIRT3), a protein deacetylase and the activities of gluconeogenic enzymes, such as phosphoenolpyruvate carboxykinase (PEPCKP), pyruvate carboxylase (PC) and malate dehydrogenase 2 (MDH2) [ 262 ]. It also acts as an anti-inflammatory mediator [ 263 , 264 ] and displays antibacterial properties against Staphylococcus aureus [ 265 ].…”

Section: Fatty Acidsmentioning

confidence: 99%

Secondary Metabolites with Biomedical Applications from Plants of the Sarraceniaceae Family

Miclea

2022

IJMS

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Carnivorous plants have fascinated researchers and hobbyists for centuries because of their mode of nutrition which is unlike that of other plants. They are able to produce bioactive compounds used to attract, capture and digest prey but also as a defense mechanism against microorganisms and free radicals. The main purpose of this review is to provide an overview of the secondary metabolites with significant biological activity found in the Sarraceniaceae family. The review also underlines the necessity of future studies for the biochemical characterization of the less investigated species. Darlingtonia, Heliamphora and Sarracenia plants are rich in compounds with potential pharmaceutical and medical uses. These belong to several classes such as flavonoids, with flavonol glycosides being the most abundant, monoterpenes, triterpenes, sesquiterpenes, fatty acids, alkaloids and others. Some of them are well characterized in terms of chemical properties and biological activity and have widespread commercial applications. The review also discusses biological activity of whole extracts and commercially available products derived from Sarraceniaceae plants. In conclusion, this review underscores that Sarraceniaceae species contain numerous substances with the potential to advance health. Future perspectives should focus on the discovery of new molecules and increasing the production of known compounds using biotechnological methods.

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“…In this light, conventional formulations should not be neglected and a focus on simple nanoparticle design should be prioritized to facilitate translation when possible. For example, palmitoleic acid (1% w/w) showed significant antibacterial properties against S. aureus in vitro when formulated as a surfactant-free, oil-in water emulsion with triolein (1-3% w/w) and water [152]. Another promising example is the antibacterial and anti-biofilm activity against Gram-positive and Gram-negative pathogens of a non-aqueous 5% (w/w) GML monoglyceride gel that was observed in vitro [153].…”

Section: Regulatory Considerationsmentioning

confidence: 99%

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Tan

Yoon

Cho

et al. 2021

IJMS

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There is enormous interest in utilizing biologically active fatty acids and monoglycerides to treat phospholipid membrane-related medical diseases, especially with the global health importance of membrane-enveloped viruses and bacteria. However, it is difficult to practically deliver lipophilic fatty acids and monoglycerides for therapeutic applications, which has led to the emergence of lipid nanoparticle platforms that support molecular encapsulation and functional presentation. Herein, we introduce various classes of lipid nanoparticle technology and critically examine the latest progress in utilizing lipid nanoparticles to deliver fatty acids and monoglycerides in order to treat medical diseases related to infectious pathogens, cancer, and inflammation. Particular emphasis is placed on understanding how nanoparticle structure is related to biological function in terms of mechanism, potency, selectivity, and targeting. We also discuss translational opportunities and regulatory needs for utilizing lipid nanoparticles to deliver fatty acids and monoglycerides, including unmet clinical opportunities.

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Selective Antibacterial Activity of Palmitoleic Acid in Emulsions and Other Formulations

Cited by 8 publications

References 36 publications

Antibacterial activities of Polyalthia longifolia leaf extracts on multiple antibiotic-resistant bacteria isolated from hospital fomites in Akure, Nigeria

Antibacterial activities of Polyalthia longifolia leaf extracts on multiple antibiotic-resistant bacteria isolated from hospital fomites in Akure, Nigeria

Secondary Metabolites with Biomedical Applications from Plants of the Sarraceniaceae Family

Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

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