Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Tan, Jia Wei; Yoon, Bo Kyeong; Cho, Nam‐Joon; Lovrić, Jasmina; Jug, Mario; Jackman, Joshua A.

doi:10.3390/ijms22189664

Cited by 23 publications

(18 citation statements)

References 155 publications

(183 reference statements)

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“…Such membrane interactions can be observed in LDH release studies and were reported to be considered beneficial for particle uptake when they do not affect cell viability. ( Tan et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Investigation of Cellular Interactions of Lipid-Structured Nanoparticles With Oral Mucosal Epithelial Cells

Jeitler

Glader

Tetyczka

et al. 2022

Front. Mol. Biosci.

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Lipid-based nanosystems enable intracellular delivery of drugs in the oral cavity for the treatment of local diseases. To rationally design such systems, suitable matrix compositions and particle properties need to be identified, and manufacturing technologies that allow reproducible production have to be applied. This is a prerequisite for the reliable and predictable performance of in-vitro biological studies. Here, we showed that solid lipid nanoparticles (SLN, palmitic acid) and nanostructured lipid carriers (NLC, palmitic acid and oleic acid in different ratios) with a size of 250 nm, a negative zeta potential, and a polydispersity index (PdI) of less than 0.3 can be reproducibly prepared by high-pressure homogenization using quality by design and a predictive model. SLN and NLC were colloidally stable after contact with physiological fluid and did not form agglomerates. The in-vitro studies clearly showed that besides particle size, surface charge and hydrophobicity, matrix composition had a significant effect. More specifically, the addition of the liquid lipid oleic acid increased the cellular uptake capacity without changing the underlying uptake mechanism. Regardless of the matrix composition, caveolin-mediated endocytosis was the major route of uptake, which was confirmed by particle localization in the endoplasmic reticulum. Thus, this work provides useful insights into the optimal composition of lipid carrier systems to enhance the intracellular uptake capacity of drugs into the oral mucosa.

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Section: Discussionmentioning

confidence: 99%

Investigation of Cellular Interactions of Lipid-Structured Nanoparticles With Oral Mucosal Epithelial Cells

Jeitler

Glader

Tetyczka

et al. 2022

Front. Mol. Biosci.

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“…Considering that shorter-chain antimicrobial lipids typically have greater solubility in aqueous environments as well, these findings support that undecanoic acid and monoundecanoin are attractive candidates for further development as membrane-disrupting antimicrobial lipids. Note that undecanoic acid is already used within antifungal creams while our results suggest that it might also be useful for other aqueous-based formulations such as lipid-based nanoparticles [ 59 ].…”

Section: Resultsmentioning

confidence: 99%

Nanoarchitectonics-based model membrane platforms for probing membrane-disruptive interactions of odd-chain antimicrobial lipids

Yoon

Tan

et al. 2022

Nano Convergence

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The use of nanoscience tools to investigate how antimicrobial lipids disrupt phospholipid membranes has greatly advanced molecular-level biophysical understanding and opened the door to new application possibilities. Until now, relevant studies have focused on even-chain antimicrobial lipids while there remains an outstanding need to investigate the membrane-disruptive properties of odd-chain antimicrobial lipids that are known to be highly biologically active. Herein, using the quartz crystal microbalance-dissipation (QCM-D) and electrochemical impedance spectroscopy (EIS) techniques, we investigated how an 11-carbon, saturated fatty acid and its corresponding monoglyceride—termed undecanoic acid and monoundecanoin, respectively—disrupt membrane-mimicking phospholipid bilayers with different nanoarchitectures. QCM-D tracking revealed that undecanoic acid and monoundecanoin caused membrane tubulation and budding from supported lipid bilayers, respectively, and were only active above their experimentally determined critical micelle concentration (CMC) values. Monoundecanoin was more potent due to a lower CMC and electrochemical impedance spectroscopy (EIS) characterization demonstrated that monoundecanoin caused irreversible membrane disruption of a tethered lipid bilayer platform at sufficiently high compound concentrations, whereas undecanoic acid only induced transient membrane disruption. This integrated biophysical approach also led us to identify that the tested 11-carbon antimicrobial lipids cause more extensive membrane disruption than their respective 12-carbon analogues at 2 × CMC, which suggests that they could be promising molecular components within next-generation antimicrobial nanomedicine strategies.

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“…Similarly, several other lipid-based NPs, such as nanostructured lipid carriers (NLCs), lipid nanocapsules (LNCs), polymer lipid NPs, and lipid-based micelles, were developed to deliver various drugs. − For instance, Kiss et al developed DEX-encapsulated nanostructured lipid carriers for ophthalmic use . Toxicity assessments on human cornea cells showed favorable ophthalmic tolerability of NLCs .…”

Section: Dexamethasone Delivery Systemsmentioning

confidence: 99%

Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery Systems

Madamsetty

Mohammadinejad

Uzielienè

et al. 2022

ACS Biomater. Sci. Eng.

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Dexamethasone (DEX) has been widely used to treat a variety of diseases, including autoimmune diseases, allergies, ocular disorders, cancer, and, more recently, COVID-19. However, DEX usage is often restricted in the clinic due to its poor water solubility. When administered through a systemic route, it can elicit severe side effects, such as hypertension, peptic ulcers, hyperglycemia, and hydro-electrolytic disorders. There is currently much interest in developing efficient DEX-loaded nanoformulations that ameliorate adverse disease effects inhibiting advancements in scientific research. Various nanoparticles have been developed to selectively deliver drugs without destroying healthy cells or organs in recent years. In the present review, we have summarized some of the most attractive applications of DEX-loaded delivery systems, including liposomes, polymers, hydrogels, nanofibers, silica, calcium phosphate, and hydroxyapatite. This review provides our readers with a broad spectrum of nanomedicine approaches to deliver DEX safely.

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Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides

Cited by 23 publications

References 155 publications

Investigation of Cellular Interactions of Lipid-Structured Nanoparticles With Oral Mucosal Epithelial Cells

Investigation of Cellular Interactions of Lipid-Structured Nanoparticles With Oral Mucosal Epithelial Cells

Nanoarchitectonics-based model membrane platforms for probing membrane-disruptive interactions of odd-chain antimicrobial lipids

Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery Systems

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