Effect of Pegylated Edge Activator on Span 60 Based- Nanovesicles: Comparison Between Myrj 52 and Myrj 59

Abstract

In recent years, Span 60 based nanovesicles have been the object of growing scientific attention as an alternative potential drug delivery system to conventional liposomes. Surface modification of nanovesicles can adjust the drug release rate and the affinity for the target site. The aim of present work was firstly to study the effects of different PEGylated edge activator (Myrj 52 and Myrj 59) on Span 60 based nanovesicles. Nanovesicles were prepared using Span 60 alone or in combination with Myrj 52 (polyethylene glycol 2000 monostearate) or Myrj 59 (polyethylene glycol 4400 monostearate) by employing the ethanol injection method. Myrj 52and Myrj 59 are hydrophilic nonionic surfactants were used to modify the surface of the developed vesicles. Dynamic light scattering was used to determine the size, zeta potential and polydispersity index of the nanovesicles formulation. The vesicles were also characterized for entrapment efficiency and in vitro release. In current work, the modified nanovesicles size (ranging from 54.32 to 141.7 nm), zeta potential (ranging from -5.67 to -27.1 mV) and polydispersity index (ranging from0.248 to 0.531) indicated that the surface modified nanovesicles vesicles are a homogenous and mono-disperse nanovesicles dispersions. The non-modified nanovesicles are showed higher particles size (>2 times) compared to modified nanovesicles. The modified nanovesicles were showed entrapment efficiency ranging from 36.42 to 78.13 %. All the modified nanovesicles showed accepted in vitro release of TN from nanovesicles (>70% released after 8 h), followed Higuchi models as drug release mechanism. In conclusion, these surface modified nanovesicles could be used as a potential drug carrier for a variety of drugs.

Formulation of Chitosan-Coated Brigatinib Nanospanlastics: Optimization, Characterization, Stability Assessment and In-Vitro Cytotoxicity Activity against H-1975 Cell Lines

“…Moreover, the Span-60:EA ratio 3:2 showed larger vesicles’ size than those of 4:1 ratio and this may be due to the higher EA concentration that led to the larger vesicles’ size. Both Tween ® 80 and Pluronic F127 are hydrophilic nonionic surfactants [ 35 ] that impart flexibility to the bilayer membranes of NSPs [ 36 ] and, thus, increase the elasticity of the vesicles and water uptake so leading to an increase in the vesicles’ size. PDI is an indicator of the vesicles’ size distribution and its value ranges from 0.0 (for completely uniform vesicles’ size distribution) to 1.0 (for highly polydispersed vesicles).…”

Preparation and Characterization of Thymoquinone Nanoparticles Pegylated as Drug Delivery System

“…The development of nanoparticles using thymoquinone as an active ingredient is based on volatility, low melting point and easily oxidized 10 .Thymoquinone is also difficult to dissolve in water, so it has a small bioavailability 9 . Therefore, thymoquinone is made in the form of nanoparticles to improve the bioavailability of drugs, improve the physical properties of chemicals 10 and protect medicinal ingredients so as to provide an effective therapeutic effect 17 . In this study, the resulting nanoparticle TQ-NP was characterized by evaluating nanoparticle morphology, size and distribution of particles, measurement of entrapment efficiency (EE) and drug loading (DL), and nanoparticle release.…”

“…PEG has been widely used in various nanoparticle systems to increase surface hydrophilicity and half-life by interacting with blood and mononuclear phagocyte cell systems. Pegylation is formed because physical adsorption or covalent grafting results in a layer of PEG on the surface of the particles so that it can increase the stability of the medicinal material 17 .…”

Formulation and Evaluation of Aceclofenac Liposomes

“… To find the release kinetics. 14 Physical appearance of drug is also observed, its color, odour, taste.…”