Effect of Oral Zinc Supplements on Growth, Hormonal Levels, and Zinc in Healthy Short Children

Ghavami-Maibodi, S Ziaadin; Collipp, P.J.; Castro‐Magana, Mariano; Stewart, Constance; Chen, S Y

doi:10.1159/000176660

Cited by 60 publications

(11 citation statements)

References 17 publications

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“…Our findings were supported by other studies [3-5,17,18] who reported that Zn supplementation was effective for inducing growth in short children with Zn deficiency in a rate similar to that in healthy children. However, in some studies, this effect was not observed [6,7].…”

Section: Discussionsupporting

confidence: 91%

Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency

2012

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BackgroundThe relationship between zinc (Zn) and growth hormone-insulin growth factor (GH-IGF) system and how Zn therapy stimulates growth in children has not been clearly defined in humans. Thus, we aimed to assess GH-IGF axis in short children with Zn deficiency and to investigate the effect of Zn supplementation on these parameters.MethodsFifty pre-pubertal Egyptian children with short stature and Zn deficiency were compared to 50 age-, sex-, and pubertal stage- matched controls. All subjects were subjected to history, auxological assessment and measurement of serum Zn, IGF-1, insulin growth factor binding protein-3 (IGFBP-3); and basal and stimulated GH before and 3 months after Zn supplementation (50 mg/day).ResultsAfter 3 months of Zn supplementation in Zn-deficient patients, there were significant increases in height standard deviation score (SDS, P = 0.033), serum Zn (P < 0.001), IGF-1 (P < 0.01), IGF-1 standard deviation score (SDS,P < 0.01) and IGFBP-3 (P = 0.042). Zn rose in all patients but reached normal ranges in 64 %, IGF-1 levels rose in 60 % but reached normal ranges in 40 % and IGFBP-3 levels rose in 40 % but reached reference ranges in 22 %. Growth velocity (GV) SDS did not differ between cases and controls (p = 0.15) but was higher in GH-deficient patients than non-deficient ones, both having Zn deficiency (p = 0.03).ConclusionSerum IGF-1 and IGFBP-3 levels were low in short children with Zn deficiency, and increased after Zn supplementation for 3 months but their levels were still lower than the normal reference ranges in most children; therefore, Zn supplementation may be necessary for longer periods.

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Section: Discussionsupporting

confidence: 91%

Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency

2012

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“…Low serum and hair zinc concentration and improved growth under oral zinc supple mentation were observed in most infants and children with growth retardation due to zinc deficiency [11,16,26,29,37], Therefore, it was of interest to compare parameters of zinc nutritional status of the infants enrolled in the three studies who were fed the formula without zinc fortification. Infants studied by Walravens et al [37] had substantially lower serum and hair zinc values at 6 months of age than infants studied by Higashi [19] at 5 months of age and the premature infants of this study at 121 days of age.…”

Section: Discussionmentioning

confidence: 99%

Growth, Zinc and Copper Nutritional Status of Male Premature Infants with Different Zinc Intake

Haschke¹,

Singer²,

Baumgärtner³

et al. 1985

Ann Nutr Metab

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Zinc is an essential nutrient for growth and low intake can result in growth retardation. However, high zinc intake can affect copper metabolism. Therefore, data from a study of 10 male premature infants fed a cow’s milk-based formula nonfortified with zinc (mean ± SD = 1.4 ± 0.1 mg·1^-1) were compared with data of 10 similar infants fed the same formula fortified with zinc (4.1 ± 0.3 mg·1^-1). Growth, food intake, zinc and copper nutritional status were studied from 6 through 122 days of age. No differences in gain of weight, length and head circumference and in food intake were found. Serum zinc concentration was significantly (p < 0.05) and hair zinc concentration was slightly higher in the infants fed the zinc-fortified formula at 122 days of age. Copper and ceruloplasmin concentrations in serum and hair copper concentration were similar in both groups at 122 days of age. The results suggest that feeding a formula nonfortified with zinc did not affect growth of male premature infants. Feeding a zinc-fortified formula on the other hand had no influence on copper nutritional status.

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“…Ghavami-Maibodi et al 9 acompanharam dois grupos de crianças com baixa velocidade de crescimento, suplementadas com doses variadas de zinco: um, com 50mg/Zn/dia por dois meses e, subseqüentemente, 50mg/Zn/dia uma vez por semana por dez meses; outro, com 100mg/Zn/ dia por um ano. Evidenciaram um aumento estatisticamente significativo tanto na taxa de crescimento, como nas concentrações de zinco no cabelo, soro e urina, de ambos os grupos, embora os efeitos fossem mais pronunciados no grupo suplementado com a dose maior.…”

Section: E F E I T O S D a S U P L E M E N T A ç ã O C O M Z I N C O unclassified

Efeitos da suplementação com zinco sobre o crescimento, sistema imunológico e diabetes

Sena

Pedrosa

2005

Rev. Nutr.

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O zinco apresenta funções catalíticas, estruturais e reguladoras, sendo componente de várias enzimas. Os sintomas observados na deficiência deste elemento incluem lesões de pele, anorexia, retardo do crescimento, hipogonadismo e alteração na função imune. O objetivo desta revisão foi apresentar as funções metabólicas e funcionais do zinco, enfatizando as conseqüências da deficiência e os aspectos que justificam os estudos envolvendo a suplementação com zinco e seus efeitos sobre o crescimento, sistema imunológico e diabetes. Considerando que algumas doenças predispõem o organismo à deficiência de zinco, a suplementação, isoladamente ou associada a outros elementos, demonstra benefícios, especialmente no aumento da velocidade de crescimento, funcionamento do sistema imunológico, diminuição das afecções respiratórias e controle das diarréias. A suplementação em pacientes com diabetes está relacionada com as variáveis do controle metabólico e as concentrações plasmáticas e eritrocitárias de zinco. As estratégias de suplementação com zinco, em populações de risco, devem ser implementadas, considerando-se as doses adequadas de ingestão. Termos de indexação: crescimento, diabetes, sistema imunológico, suplementação, zinco. A B S T R A C T Zinc has catalytic, structural and regulatory functions and is a component of many enzymes. Skin lesions

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Effect of Oral Zinc Supplements on Growth, Hormonal Levels, and Zinc in Healthy Short Children

Cited by 60 publications

References 17 publications

Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency

Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency

Growth, Zinc and Copper Nutritional Status of Male Premature Infants with Different Zinc Intake

Efeitos da suplementação com zinco sobre o crescimento, sistema imunológico e diabetes

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