Effect of Oral Vitamin C Supplementation on High-Altitude Hyperuricemia in Young Men Initially Migrating to High Altitude: A Pilot Study

Peng, Hui; Feng, Dongfang; Wang, Yingkai; Dong, Zixi; Chen, Qing; Zhang, Lihong; Luo, Ruigang; Chen, Jinsong; Wang, Anjun; Ma, Shiwu

doi:10.1089/ham.2018.0058

Cited by 9 publications

(8 citation statements)

References 42 publications

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“…The oldest [44,46,47] were focused on the uricosuric effect of vitamin C supplementation. Further work focused on SUA levels in the healthy population and patients with various chronic diseases, including end-stage renal disease [66][67][68][69][70][71][72][73][74]. The last subgroup consisted of studies where patients with gout in their clinical history were included [44,75,76].…”

Section: Interventional Studiesmentioning

confidence: 99%

“…Another analyzed subgroup of studies are experiments aimed at assessing the effect of ascorbic acid supplementation on the level of uric acid in the blood serum in healthy people. In most of the presented studies, VC was supplemented at a dose of 500 mg/d [66,68,74], one VC was supplemented at a dose of 1000 mg/d [67]; all studies were double-blind, placebo-controlled studies. The first study by Baser et al [66] showed no significant reduction in SUA.…”

Section: Study Study Population Follow-up Duration Intervention Exclumentioning

confidence: 99%

“…Only young men who, apart from VC supplementation with 1000 mg [67] or 500 mg/d [74], were subjected to intensive physical training, and being at high altitude [74], were qualified for the remaining two studies. In both cases, the effect of VC supplementation was to reduce the increase in SUA associated with accelerated metabolism resulting from increased physical exertion.…”

Section: Study Study Population Follow-up Duration Intervention Exclumentioning

confidence: 99%

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Role of Vitamin C in Prophylaxis and Treatment of Gout—A Literature Review

et al. 2021

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Gout, known as “the disease of the kings”, is the most frequent type of arthritis. It results from sustained hyperuricemia that leads to monosodium urate crystal deposition in joint structures and soft tissue. Environmental factors such as diet affect the incidence of gout; there is a known relationship between the occurrence of an acute attack of gout and the consumption of alcohol and meat; and a low purine diet is a widely recognized nonpharmacological method of supplementing the treatment and preventing recurrence of arthritis. This review aims to summarize the current knowledge about the role of vitamin C in prevention and treatment of gout. A PubMed/Medline database search on the role of vitamin C in purine metabolism was done. Reports from in vitro and animal studies seem to be promising and to allow explanation of the physiological relationship between vitamin C and uric acid. Most epidemiological studies indicate a significant correlation between high vitamin C intake and lower serum uric acid levels. Despite promising observations, there are few observational and interventional studies, and their results do not clearly define the benefits of a high daily intake of vitamin C in preventing the development and recurrence of gout.

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Section: Interventional Studiesmentioning

confidence: 99%

Section: Study Study Population Follow-up Duration Intervention Exclumentioning

confidence: 99%

Section: Study Study Population Follow-up Duration Intervention Exclumentioning

confidence: 99%

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Role of Vitamin C in Prophylaxis and Treatment of Gout—A Literature Review

et al. 2021

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“…Vitamin E is a fat-soluble antioxidant. A growing body of evidence suggests that dietary vitamin E intake is related to serum uric acid levels [12, 13]. An experimental study reported that vitamin E treatment increased urinary excretion of uric acid and reduced serum uric acid levels in deoxycorticosterone-salt-treated rats [14].…”

Section: Introductionmentioning

confidence: 99%

“…An experimental study reported that vitamin E treatment increased urinary excretion of uric acid and reduced serum uric acid levels in deoxycorticosterone-salt-treated rats [14]. Furthermore, a preliminary prospective control study conducted among young male army recruits revealed that oral vitamin E supplementation mitigated increases in serum uric acid levels within 1 month of moving from a low- to high-altitude region [12]. A cross-sectional study assessed the relationship between dietary vitamin E intake and serum uric acid levels in Caucasian cohorts, reporting inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

Dietary Vitamin E Intake Was Inversely Associated with Hyperuricemia in US Adults: NHANES 2009–2014

Zhang

Shi

et al. 2020

Ann Nutr Metab

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Introduction: Current evidence on the association between dietary vitamin E intake and hyperuricemia risk is limited and conflicting. Objective: The aim of the study was to assess the association of dietary vitamin E intake with hyperuricemia in US adults. Methods: We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey, 2009–2014. Dietary vitamin E intake was evaluated through two 24-h dietary recall interviews. Logistic regression and restricted cubic spline models were used to examine the association between dietary vitamin E intake and hyperuricemia. Results: Overall, 12,869 participants were included. The prevalence of hyperuricemia was 19.35%. After adjustment for age, gender, BMI, race, educational level, smoking status, alcohol consumption, physical activity, total daily energy intake, total cholesterol, protein intake, glomerular filtration rate, serum Cr, use of uric acid drugs, and drug abuse, the odds ratio (95% confidence interval) of hyperuricemia for the highest tertile of dietary vitamin E intake was 0.77 (0.63–0.96) compared with that of the lowest tertile. In men, dietary vitamin E intake and hyperuricemia were negatively correlated. In stratified analyses by age (20–39, 40–59, and ≥60 years), dietary vitamin E intake was inversely associated with hyperuricemia only among participants aged ≥60 years. Dose-response analyses showed that dietary vitamin E intake was inversely associated with hyperuricemia in a nonlinear manner. Conclusion: Dietary vitamin E intake was negatively correlated with hyperuricemia in US adults, especially among males and participants aged ≥60 years.

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Serum Metabolomics Identifies Dysregulated Pathways and Potential Metabolic Biomarkers for Hyperuricemia and Gout

Shen

Wang

Liang

et al. 2021

Arthritis & Rheumatology

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Objective To systematically profile metabolic alterations and dysregulated metabolic pathways in hyperuricemia and gout, and to identify potential metabolite biomarkers to discriminate gout from asymptomatic hyperuricemia. Methods Serum samples from 330 participants, including 109 with gout, 102 with asymptomatic hyperuricemia, and 119 normouricemic controls, were analyzed by high‐resolution mass spectrometry–based metabolomics. Multivariate principal components analysis and orthogonal partial least squares discriminant analysis were performed to explore differential metabolites and pathways. A multivariate methods with Unbiased Variable selection in R (MUVR) algorithm was performed to identify potential biomarkers and build multivariate diagnostic models using 3 machine learning algorithms: random forest, support vector machine, and logistic regression. Results Univariate analysis demonstrated that there was a greater difference between the metabolic profiles of patients with gout and normouricemic controls than between the metabolic profiles of individuals with hyperuricemia and normouricemic controls, while gout and hyperuricemia showed clear metabolomic differences. Pathway enrichment analysis found diverse significantly dysregulated pathways in individuals with hyperuricemia and patients with gout compared to normouricemic controls, among which arginine metabolism appeared to play a critical role. The multivariate diagnostic model using MUVR found 13 metabolites as potential biomarkers to differentiate hyperuricemia and gout from normouricemia. Two‐thirds of the samples were randomly selected as a training set, and the remainder were used as a validation set. Receiver operating characteristic analysis of 7 metabolites yielded an area under the curve of 0.83–0.87 in the training set and 0.78–0.84 in the validation set for distinguishing gout from asymptomatic hyperuricemia by 3 machine learning algorithms. Conclusion Gout and hyperuricemia have distinct serum metabolomic signatures. This diagnostic model has the potential to improve current gout care through early detection or prediction of progression to gout from hyperuricemia.

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Effect of Oral Vitamin C Supplementation on High-Altitude Hyperuricemia in Young Men Initially Migrating to High Altitude: A Pilot Study

Cited by 9 publications

References 42 publications

Role of Vitamin C in Prophylaxis and Treatment of Gout—A Literature Review

Role of Vitamin C in Prophylaxis and Treatment of Gout—A Literature Review

Dietary Vitamin E Intake Was Inversely Associated with Hyperuricemia in US Adults: NHANES 2009–2014

Serum Metabolomics Identifies Dysregulated Pathways and Potential Metabolic Biomarkers for Hyperuricemia and Gout

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