Role of Vitamin C in Prophylaxis and Treatment of Gout—A Literature Review

Brzezińska, Olga; Styrzyński, Filip; Makowska, Joanna; Walczak, Konrad

doi:10.3390/nu13020701

Cited by 25 publications

(27 citation statements)

References 73 publications

(147 reference statements)

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“…Gout is the most common form of arthritic disease. 1 From 1992 to 2017, the global incidence and prevalence of gout increased by 37% and 41%, respectively. 2 Currently, it is not yet proven that diet and lifestyle change can reduce high uric acid; therefore, patients need to use related drugs and other special treatment methods.…”

Section: Introductionmentioning

confidence: 99%

Tongbixiao Pills Improve Gout by Reducing Uric Acid Levels and Inhibiting Inflammation

ZhiguoShao

et al. 2022

Dose-Response

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Gout is a chronic disease. Gout symptoms are often experienced in the middle of the night. The onset of gout in the middle of the night is closely related to abnormal liver and gallbladder meridian. The purpose of this study was to investigate the clinical efficacy and possible mechanism of action of Tongbixiao pills in the treatment of hyperuricemia and gouty arthritis. The Tongbixiao pills we used included several traditional Chinese medicines, most of which tonify the spleen; strengthen the liver; benefit the kidney; and reduce heat, dampness, and blood stasis. In this randomized clinical study of 105 patients, we found that Tongbixiao pills can reduce uric acid levels in hyperuricemia patients. Additionally, the efficacy was similar to that of allopurinol and the level of uric acid did not increase significantly at eight weeks after withdrawal. In the absence of notable adverse reactions, Tongbixiao pills can also increase uric acid excretion, reduce serum creatinine and lipid levels, and reduce inflammation and relieve gout symptoms. In addition, we used SD rats to simulate gout and arthritis and divided them into five groups: normal group, model group, low-dose group, medium-dose group, and high-dose group. The inflammatory indices of the 40 SD rats were observed. After seven days, ankle swelling in rats in the treatment group was significantly reduced. The indices of uric acid, creatinine, and urea nitrogen in the treatment group were significantly lower than those in the model group, which proved that Tongbixiao pills could inhibit hyperuricemia in rats, thus treating gout. This study demonstrates that Tongbixiao pills can treat gout, provide more treatment options for gouty arthritis, and improve the quality of life of patients.

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Section: Introductionmentioning

confidence: 99%

Tongbixiao Pills Improve Gout by Reducing Uric Acid Levels and Inhibiting Inflammation

ZhiguoShao

et al. 2022

Dose-Response

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“…Although many epidemiological studies indicate a significant correlation between high vitamin C intake and lower serum uric acid levels, data is still mixed and primarily related to the populations studied [35,36]. Pharmacologically, the uricosuric effects of vitamin C seem to have the highest impact on hyperuricemia.…”

Section: Vitamin Supplementation In the Treatment Of Goutmentioning

confidence: 99%

Nutritional factors in the prevention and treatment of gout

Sebastian

Wąsik²,

Wojtuś³

2023

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Introduction and purpose: Despite the fact that effective urate lowering therapy and anti-inflammatory drugs for the treatment of gout are commonly available, there is considerable interest in novel treatment approaches. Gouty patients often have a multitude of comorbidities, which lead to concern over drug–drug interactions and medication adverse events. Thus, diet modifications are examined as a way of nonpharmacological treatment of gout. In this review, we explore the potential impact of nutritional factors on hyperuricemia and clinical gout outcomes. A search was conducted using PubMed and Google Scholarship databases. Brief description of the state of knowledge: Management in patients with gout should be holistic. Incorrect nutrition may lead to hyperuricemia. Studies to date suggest that avoidance of certain foods and beverages can decrease the frequency of gout flares. Weight loss may be beneficial for prevention as well as treatment of gout and its comorbidities. The impact of various types of diet on the course of gout has been given particular attention and recent research suggests that vegetarian, mediterranean and dash diets may be beneficial for gouty patients. Also, some vitamins and omega-3 PUFA have favorable effects and the potential clinical use in gout treatment. Conclusions: We propose that simple dietary regimens may be beneficial to complement therapeutic management or contribute to the prevention of flares in gout patients. Although piecemeal modifications of various nutrients often provide incomplete dietary recommendations, understanding the role of nutritional factors in gout development would be helpful for patients in choosing their healthy diet.

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“…Диета, богатая фруктами и овощами, обычно приводит к ощелачиванию мочи и способствует выведению МК с мочой [55,56]. Результаты исследований демонстрируют значительную корреляцию между высоким потреблением витамина С как с пищей, так и в виде биологически активных добавок, и более низким уровнем МК, что, вероятно, связано с его урикозурическим эффектом [57].…”

Section: Hyperuricemia and Diet гиперурикемия и рацион питанияunclassified

Hyperuricemia: Features of the Diet

Швабская¹,

Измайлова²,

Карамнова³

et al. 2022

Racionalʹnaâ farmakoterapiâ v kardiologii

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The association of hyperuricemia (HU) with cardiovascular disease (CVD), diabetes, metabolic syndrome, and kidney disease has been demonstrated in numerous studies. НU is the main pathogenetic factor in the development of gout and is associated with an increase in overall and cardiovascular mortality. НU is included in the list of factors determining cardiovascular risk. According to epidemiological studies, there is a high prevalence of HU in the world and its increase in recent decades. A number of factors have been identified that contribute to the increased risk of НU. Non-modifiable factors include gender, age, genetic factors, and modifiable factors include diet and lifestyle. Nutritional unbalances, increased life expectancy, increased prevalence of obesity, and increased use of drugs (especially diuretics) are seen as contributing factors to the rise in НU. The review was carried out to summarize the available information on the effect of dietary habits, individual foods and nutrients on serum uric acid (SUA) levels and the risk of developing HU. The review presents the results of scientific studies demonstrating the relationship of НU with the consumption of foods rich in purines (offal, red meat, fish, seafood, legumes), alcohol consumption, drinks sweetened with fructose, coffee, dairy products, vegetables and fruits. Diet correction is an important and necessary step in the prevention and treatment of НU. The article reviews the basic principles of dietary management in HU and provides dietary recommendations for patients. For effective prevention and treatment of НU, a mandatory correction of the diet is required.

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Role of Vitamin C in Prophylaxis and Treatment of Gout—A Literature Review

Cited by 25 publications

References 73 publications

Tongbixiao Pills Improve Gout by Reducing Uric Acid Levels and Inhibiting Inflammation

Tongbixiao Pills Improve Gout by Reducing Uric Acid Levels and Inhibiting Inflammation

Nutritional factors in the prevention and treatment of gout

Hyperuricemia: Features of the Diet

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