Effect of off-pump coronary surgery with right ventricular assist device on organ function and inflammatory response: a randomized controlled trial

Caputo, Massimo; Yeatman, Mark; Narayan, Pradeep; Marchetto, G; Ascione, Raimondo; Reeves, Barnaby C; Angelini, Gianni D

doi:10.1016/s0003-4975(02)04025-0

Cited by 49 publications

(20 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…in 255 the overall analysis, there was no difference between the two techniques with respect to ≤30-256 day all-cause mortality and MI; c). a significant linear relationship was found between risk 257 M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 12 profile and benefits of OPCAB for all endpoints: all-cause mortality, MI and cerebral stroke. 258 The robustness and stability of the results were confirmed in sensitivity analyses.…”

mentioning

confidence: 89%

Off-pump coronary artery bypass grafting improves short-term outcomes in high-risk patients compared with on-pump coronary artery bypass grafting: Meta-analysis

Kowalewski

Pawliszak

Malvindi

et al. 2016

The Journal of Thoracic and Cardiovascular Surgery

182

128

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 89%

Off-pump coronary artery bypass grafting improves short-term outcomes in high-risk patients compared with on-pump coronary artery bypass grafting: Meta-analysis

Kowalewski

Pawliszak

Malvindi

et al. 2016

The Journal of Thoracic and Cardiovascular Surgery

182

128

View full text Add to dashboard Cite

show abstract

“…CPB is a major trigger of inflammatory response during cardiac surgery since off-pump surgery has been shown to significantly reduce inflammatory response (e.g. (Ascione, et al, 2000;Caputo, et al, 2002;Nesher, et al, 2006)). CPB can impact upon the cellular and non-cellular elements of blood resulting in the activation of different pro-inflammatory cascades (Anselmi, et al, 2004;Hill, 1998;Khoynezhad, Jalali, & Tortolani, 2004;Rinder, 2006;Suleiman, Zacharowski, & Angelini, 2008).…”

Section: Systemic Inflammatory Response During Surgerymentioning

confidence: 99%

Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery

Zakkar

Ascione

James

et al. 2015

Pharmacology & Therapeutics

184

129

View full text Add to dashboard Cite

Postoperative atrial fibrillation (POAF) is a common complication of cardiac surgery that occurs in up to 60% of patients. POAF is associated with increased risk of cardiovascular mortality, stroke and other arrhythmias that can impact on early and long term clinical outcomes and health economics. Many factors such as disease-induced cardiac remodelling, operative trauma, changes in atrial pressure and chemical stimulation and reflex sympathetic/parasympathetic activation have been implicated in the development of POAF. There is mounting evidence to support a major role for inflammation and oxidative stress in the pathogenesis of POAF. Both are consequences of using cardiopulmonary bypass and reperfusion following ischaemic cardioplegic arrest. Subsequently, several anti-inflammatory and antioxidant drugs have been tested in an attempt to reduce the incidence of POAF. However, prevention remains suboptimal and thus far none of the tested drugs has provided sufficient efficacy to be widely introduced in clinical practice. A better understanding of the cellular and molecular mechanisms responsible for the onset and persistence of POAF is needed to develop more effective prediction and interventions.

show abstract

“…However, the studies by Caputo et al [19] and Vallely et al [33] showed a large effect on the pooled results. This may be due to the small sample sizes.…”

Section: Discussionmentioning

confidence: 87%

“…After omitting the studies by Caputo et al [19] and Vallely et al [33], the outcomes were reversed for the IL-6 concentration (SMD = 0.56, 95% CI = 0.12-1.01 [ Figure 2B]) and IL-8 concentration (SMD = 0.70, 95% CI = 0.27-1.13 [ Figure 4B]) 12 hours after operation. Other results of sensitivity analysis were consistent with the overall pooled results.…”

Section: Sensitivity Analysesmentioning

confidence: 96%

Meta-analysis of interleukin 6, 8, and 10 between off-pump and on-pump coronary artery bypass groups

Meng

Wang

et al. 2017

Bosn J of Basic Med Sci

View full text Add to dashboard Cite

This study aimed to evaluate the role of off-pump coronary artery bypass (CAB) surgery on the decrease of postoperative inflammatory responses in patients. We systematically searched databases of PubMed and Embase to select the related studies. Interleukin (IL) 6, 8, and 10 were used as outcomes and pooled analysis was performed using R 3.12 software. Standardized mean differences (SMDs) and their 95% confidence intervals (95% CIs) were considered as effect estimates. A total of 27 studies, including 1340 participants, were recruited in this meta-analysis. The pooled analyses showed that postoperative concentration of IL-10 at 12 hours was significantly lower in off-pump CAB group compared to on-pump CAB group (SMD = −1.3640, 95% CI = −2.0086-−0.7193). However, no significant differences were found in pre and postoperative concentrations of IL-6 and 8 between off-pump and on-pump CAB groups. These results suggest that there is no advantage of off-pump CAB surgery in the reduction of inflammation compared to on-pump CAB surgery.KEY WORDS: Coronary artery bypass; interleukins; meta-analysis; IL-6; IL-8; IL-10; off-pump coronary artery bypass surgery; on-pump coronary artery bypass surgery

show abstract

Effect of off-pump coronary surgery with right ventricular assist device on organ function and inflammatory response: a randomized controlled trial

Cited by 49 publications

References 32 publications

Off-pump coronary artery bypass grafting improves short-term outcomes in high-risk patients compared with on-pump coronary artery bypass grafting: Meta-analysis

Off-pump coronary artery bypass grafting improves short-term outcomes in high-risk patients compared with on-pump coronary artery bypass grafting: Meta-analysis

Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery

Meta-analysis of interleukin 6, 8, and 10 between off-pump and on-pump coronary artery bypass groups

Contact Info

Product

Resources

About