Meta-analysis of interleukin 6, 8, and 10 between off-pump and on-pump coronary artery bypass groups

Meng, F.; Ma, Jun; Wang, Wei; Lin, Bin

doi:10.17305/bjbms.2017.1505

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…[ 44 ] Studies evaluating proinflammatory cytokines release after OPCAB and on-pump CABG have, however, reported contradictory results. [ 45 ] There is insubstantial evidence of reduction of the postoperative systemic inflammatory reaction and platelet activation after OPCAB. [ 46 ] The Randomized On/Off Bypass (ROOBY) trial of 2203 patients, comparing Off-pump and On-pump CABG, found no significant reduction in the incidence of POCD on shunning CPB.…”

Section: Role Of Cardiac Surgerymentioning

confidence: 99%

Neurological dysfunction after cardiac surgery and cardiac intensive care admission: A narrative review part 1: The problem; nomenclature; delirium and postoperative neurocognitive disorder; and the role of cardiac surgery and anesthesia

Kapoor

2020

Ann Card Anaesth

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The association with cardiac surgery with cognitive decline was first reported in the 1960s after the introduction of coronary artery surgery. The incidence in cognitive decline was thought to be more after cardiac surgery, especially with the use of the cardiopulmonary bypass. Anesthesia and surgery are both associated with cognitive decline but many other factors appear to contribute its genesis. On-pump surgery, microembolization during manipulation of the heart and great vessels, temperature changes, pH changes, and altered cerebral perfusion, during cardiac surgery, have all been blamed for this. Postoperative cognitive decline is associated with poor clinical outcomes and higher mortality. Several studies have been conducted in the last decade to determine the genesis of this malady. Current evidence is absolving cardiac surgery and anesthesia to be the primary causes per se of cognitive dysfunction.

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Section: Role Of Cardiac Surgerymentioning

confidence: 99%

Neurological dysfunction after cardiac surgery and cardiac intensive care admission: A narrative review part 1: The problem; nomenclature; delirium and postoperative neurocognitive disorder; and the role of cardiac surgery and anesthesia

Kapoor

2020

Ann Card Anaesth

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“…Studies that evaluated the circulating levels of proinflammatory cytokines (IL‐6, ‐8, and ‐10) after off‐ and on‐pump‐ surgery reported contradictory results 14, 18, 19, 20, 21, 22…”

Section: Differences In Systemic Inflammatory Reaction and Platelet/cmentioning

confidence: 99%

Off‐Pump Coronary Artery Bypass Grafting: 30 Years of Debate

Gaudino

Angelini

Antoniades

et al. 2018

JAHA

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“…These complications relate to surgical techniques, anesthesia, and cardiopulmonary bypass protocols [ 5 ]. Further, contact of blood components with the surface of the extracorporeal circuits, reperfusion injuries, endotoxemia, and surgical trauma are among the processes that can activate the pro-inflammatory system and cytokine release, mainly interleukin-6 (IL-6) during on-pump CABG [ 6 , 7 ]. IL-6 is a widely discussed biomarker in conjunction with extracorporeal circulation and inflammation during cardiac surgical interventions [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of multimodal low-opioid anesthesia protocol during on-pump coronary artery bypass grafting: a prospective cohort study

Stepan,

Oleh,

Oleksandr

et al. 2023

J Cardiothorac Surg

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Background The most favorable anesthesia protocol during on-pump coronary artery bypass grafting (CABG) in patients with coronary heart disease remains unclear, despite previous publications regarding the interaction between anesthesia protocol and postoperative complications. The aim of the study was to compare the effect of a multimodal low-opioid anesthesia protocol (MLOP) on early postoperative complications during on-pump CABG. Methods A single-center prospective cohort study including 120 patients undergoing on-pump CABG aged 18 to 65 years, divided into two groups according to undergoing MLOP or routine-opioid anesthesia protocol (ROP). The analyzed parameters were plasma IL-6 levels, complications, duration of mechanical ventilation, length of intensive care unit stay, and hospitalization. Results In the MLOP group, the levels of IL-6 at the end of the surgery were 25.6% significantly lower compared to the ROP group (33.4 ± 9.4 vs. 44.9 ± 15.9, p < 0.0001), the duration of mechanical ventilation was significantly shorter (2.0 (2.0; 3.0) h vs. 4.0 (3.0; 5.0) h, p < 0.001), the incidence of low cardiac output syndrome was almost two and half times lower (7 (11.7%) vs. 16 (26.7%), p = 0.037), and also the incidence of postoperative atrial fibrillation was significantly lower (9 (15.0%) vs. 19 (31.7%), p = 0.031). Conclusion Our study confirms that using MLOP was characterized by significantly lower levels of IL-6 at the end of surgery and a lower incidence of low cardiac output syndrome and postoperative atrial fibrillation than ROP. Trial registration The study is registered in clinicaltrials.gov №NCT05514652.

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Meta-analysis of interleukin 6, 8, and 10 between off-pump and on-pump coronary artery bypass groups

Cited by 8 publications

References 39 publications

Neurological dysfunction after cardiac surgery and cardiac intensive care admission: A narrative review part 1: The problem; nomenclature; delirium and postoperative neurocognitive disorder; and the role of cardiac surgery and anesthesia

Neurological dysfunction after cardiac surgery and cardiac intensive care admission: A narrative review part 1: The problem; nomenclature; delirium and postoperative neurocognitive disorder; and the role of cardiac surgery and anesthesia

Off‐Pump Coronary Artery Bypass Grafting: 30 Years of Debate

Effects of multimodal low-opioid anesthesia protocol during on-pump coronary artery bypass grafting: a prospective cohort study

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