Effect of Oestrogen on Altering the Serum and Urinary Levels of Calcium, Phosphate and Magnesium in Hysterectomised Women Compared to Natural Menopausal South Indian Women: A Case Control Study

Sonu, Yeldose; Avinash, S S; Sreekantha,; Kumar, Krv; Munisamy, Malathi; Shivashankara, Arnadi Ramachandrayya

doi:10.1007/s12291-015-0532-y

Cited by 8 publications

(3 citation statements)

References 9 publications

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“…Conversely, the re-absorption and excretion of magnesium in kidneys are influenced by several unclarified mechanisms, such as different hormone regulation [20]. It was reported that either lower or higher serum magnesium was observed among natural postmenopausal women, nevertheless, estrogen therapy could decrease its secretion in urine [21–23]. By contrast, we found that the secretion of magnesium in 24-hour urine was statistically lower among postmenopausal women than among non-menopausal women.…”

Section: Discussioncontrasting

confidence: 55%

Comparison of metabolic changes for stone risks in 24-hour urine between non- and postmenopausal women

Mai

Jiang

et al. 2019

PLoS ONE

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BackgroundTo explore the differences of 24-hour urine compositions associated with urolithiasis between non- and postmenopausal females.MethodsThe 24-hour urine samples of female participants were collected from May 2013 to July 2014 along with national cross-sectional study of urolithiasis among adults aged ≥18 years in China. The exclusion criteria for the participants were: serum creatinine > 133μmol/L, with urinary tract infection, gout, hyperthyroidism, malignancy, had a history of cancer, kidney stones, enterectomy, had taken thiazide diuretics, allopurinol, vitamin supplement, potassium citrate or calcium supplements during the past two weeks. The compositions associated with urinary stone in 24-hour urine were measured and compared between non-and postmenopausal women.ResultsA total of 603 24-hour urine samples of female participants were analyzed. 354 women with a mean age of 52.5± 14.03 (range 19–84) years met the criteria, including 160 non-menopausal women and 194 postmenopausal women. Compared to the non-menopausal women, postmenopausal women had a lower secretion of citrate (p = 0.043), magnesium (p = 0.001) and creatinine (p = 0.001) in 24h urine. Multivariate linear regression analysis showed that the menopause status was associated with the changes in magnesium (p = 0.003) and creatinine (p = 0.002) secretion, whereas not with the changes in citrate (p = 0.402) secretion.ConclusionsPostmenopausal women have a significant lower secretion of magnesium in their 24-hour urine than non-menopausal ones. We suppose that might be associated with increased risk of urinary stone formation among postmenopausal women.

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Section: Discussioncontrasting

confidence: 55%

Comparison of metabolic changes for stone risks in 24-hour urine between non- and postmenopausal women

Mai

Jiang

et al. 2019

PLoS ONE

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“…It was shown in one of the study that serum calcium decreased, but in contrast to the present study ,serum magnesium increased in postmenopausal women when compared to premenopausal women. 21 Also there was increased urinary calcium/ creatinine and urine magnesium/creatinine ratio. Decrease in oestrogen causes decreased activity of osteoblasts and increased activity of osteoclasts causing demineralization and ultimately osteoporosis in postmenopausal women.…”

Section: Discussionmentioning

confidence: 96%

A Comparative Study of Serum Calcium and Magnesium in Post-Menopausal and Pre- Menopausal Women

Vani

2023

jmscr

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Background: Menopause is marked by decreased female sex hormones and many of the symptoms experienced during this phase may be related to changes in serum levels of certain trace minerals especially calcium and magnesium. Aim: The main purpose of the study was to measure serum calcium and magnesium in postmenopausal women and to compare with that in pre-menopausal women. Methods: Serum calcium and magnesium were estimated in 30 postmenopausal women and 30 premenopausal women, who were selected following inclusion and exclusion criteria. Statistical analysis was done by using Graph pad Quickcalcs calculator. Student's unpaired t test was done to compare between both groups and p-value was determined to know the statistical significance. Results: Postmenopausal women were found to have lower serum calcium (8.659±0.91) and serum magnesium (1.63±0.16) when compared to premenopausal women who had serum calcium of (9.604 ± 0.70) and serum magnesium (2.48±0.55). The lowered calcium and magnesium levels were found to be extremely statistically significant with a p-value of <0.0001. Conclusion: Serum calcium and magnesium were decreased in post-menopausal women when compared to pre-menopausal women, which needs to be corrected to avoid certain postmenopausal symptoms and other serious health problems. This may improve cardiovascular and bone health in post menopausal women.

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“…Elevated levels of muscle Mg 2+ in the EF phase may effectively counteract Ca 2+ to mitigate muscle spasms or twitches resulting from excessive muscle contraction due to Ca 2+ accumulation. Furthermore, it is noteworthy that natural postmenopausal women typically exhibit lower serum estrogen levels in conjunction with higher magnesium levels when compared to healthy premenopausal women [54]. Additionally, estrogen supplementation has been shown to reduce the hypermagnesuria observed in postmenopausal women [55].…”

Section: Ph and Free Mg Measurementsmentioning

confidence: 99%

17β-Estradiol Effects in Skeletal Muscle: A 31P MR Spectroscopic Imaging (MRSI) Study of Young Females during Early Follicular (EF) and Peri-Ovulation (PO) Phases

Ren,

Rodriguez,

Johnson

et al. 2024

Diagnostics

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The natural variation in estrogen secretion throughout the female menstrual cycle impacts various organs, including estrogen receptor (ER)-expressed skeletal muscle. Many women commonly experience increased fatigue or reduced energy levels in the days leading up to and during menstruation, when blood estrogen levels decline. Yet, it remains unclear whether endogenous 17β-estradiol, a major estrogen component, directly affects the energy metabolism in skeletal muscle due to the intricate and fluctuating nature of female hormones. In this study, we employed 2D 31P FID-MRSI at 7T to investigate phosphoryl metabolites in the soleus muscle of a cohort of young females (average age: 28 ± 6 years, n = 7) during the early follicular (EF) and peri-ovulation (PO) phases, when their blood 17β-estradiol levels differ significantly (EF: 28 ± 18 pg/mL vs. PO: 71 ± 30 pg/mL, p < 0.05), while the levels of other potentially interfering hormones remain relatively invariant. Our findings reveal a reduction in ATP-referenced phosphocreatine (PCr) levels in the EF phase compared to the PO phase for all participants (5.4 ± 4.3%). Furthermore, we observe a linear correlation between muscle PCr levels and blood 17β-estradiol concentrations (r = 0.64, p = 0.014). Conversely, inorganic phosphate Pi and phospholipid metabolite GPC levels remain independent of 17β-estradiol but display a high correlation between the EF and PO phases (p = 0.015 for Pi and p = 0.0008 for GPC). The robust association we have identified between ATP-referenced PCr and 17β-estradiol suggests that 17β-estradiol plays a modulatory role in the energy metabolism of skeletal muscle.

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Effect of Oestrogen on Altering the Serum and Urinary Levels of Calcium, Phosphate and Magnesium in Hysterectomised Women Compared to Natural Menopausal South Indian Women: A Case Control Study

Cited by 8 publications

References 9 publications

Comparison of metabolic changes for stone risks in 24-hour urine between non- and postmenopausal women

Comparison of metabolic changes for stone risks in 24-hour urine between non- and postmenopausal women

A Comparative Study of Serum Calcium and Magnesium in Post-Menopausal and Pre- Menopausal Women

17β-Estradiol Effects in Skeletal Muscle: A 31P MR Spectroscopic Imaging (MRSI) Study of Young Females during Early Follicular (EF) and Peri-Ovulation (PO) Phases

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