Effect of occupational exposure to cobalt blue dyes on the thyroid volume and function of female plate painters.

Prescott, E; Netterstrøm, Bo; Faber, Jens; Hegedűs, László; Suadicani, Poul; Christensen, Jytte Molin

doi:10.5271/sjweh.1605

Cited by 39 publications

(19 citation statements)

References 14 publications

(13 reference statements)

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“…One patient died of hepatic congestion, although the authors postulated this as secondary to congestive heart failure rather than primary hepatic pathology. 87 Gross pathology demonstrated significant hyperaemia and inflammation, while light microscopy demonstrated central vein displacement, condensation of hepatocyte cytoplasm, steatosis, increased inflammatory infiltrate, and destruction of mitochondrial cristae. 87 In animal studies, a dose-response relationship has been reported between elevated liver enzymes and cobalt ingestion.…”

Section: Hepaticmentioning

confidence: 97%

“…87 Gross pathology demonstrated significant hyperaemia and inflammation, while light microscopy demonstrated central vein displacement, condensation of hepatocyte cytoplasm, steatosis, increased inflammatory infiltrate, and destruction of mitochondrial cristae. 87 In animal studies, a dose-response relationship has been reported between elevated liver enzymes and cobalt ingestion. 87 To date, there has been only one report of hepatotoxicity, as evidenced by elevated liver enzymes or serum bilirubin levels, associated with elevated serum cobalt levels following a Co-Cr containing THA.…”

Section: Hepaticmentioning

confidence: 97%

“…37,81 Thyroid Much of what is known about the thyrotoxic effects of cobalt comes from its use in the treatment of anaemia and from industrial exposure to cobalt-containing dyes. 87 Patients with cobalt toxicity may develop signs and symptoms such as goitre, lassitude, lethargy, weakness, poor concentration, and diminished reflexes suggestive of hypothyroidism. 1 Cobalt can inhibit both iodine uptake and thyroperoxidase (tyrosine iodinase) activity, thereby preventing oxidation of iodide and subsequent incorporation of iodine into thyroxine.…”

Section: Cardiacmentioning

confidence: 99%

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Systemic cobalt toxicity from total hip arthroplasties

Cheung

Banerjee

Cherian

et al. 2016

The Bone & Joint Journal

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Section: Hepaticmentioning

confidence: 97%

Section: Hepaticmentioning

confidence: 97%

Section: Cardiacmentioning

confidence: 99%

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Systemic cobalt toxicity from total hip arthroplasties

Cheung

Banerjee

Cherian

et al. 2016

The Bone & Joint Journal

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“…86 Occupational exposure in a small series of Danish pottery painters showed no effect on normal thyroid function despite evidence indicating an altered thyroid metabolism. 87 A1 is known to disrupt parathyroid hormone levels, which may account for A1-induced bone disorders in dialysis patients. 82 The visual and auditory systems.…”

Section: Systemic Toxicologymentioning

confidence: 99%

Orthopaedic metals and their potential toxicity in the arthroplasty patient

Keegan

Learmonth

Case

2007

The Journal of Bone and Joint Surgery. British volume

294

196

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The long-term effects of metal-on-metal arthroplasty are currently under scrutiny because of the potential biological effects of metal wear debris. This review summarises data describing the release, dissemination, uptake, biological activity, and potential toxicity of metal wear debris released from alloys currently used in modern orthopaedics. The introduction of risk assessment for the evaluation of metal alloys and their use in arthroplasty patients is discussed and this should include potential harmful effects on immunity, reproduction, the kidney, developmental toxicity, the nervous system and carcinogenesis.

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“…We have only sporadic information on smoking habits in the studied population froin two small surveys (22,23). The response rate was 94% for the cobalt-exposed and 88% for the referents in 1982, while it was not known for the 1988 study.…”

Section: Discussionmentioning

confidence: 99%

Incidence of lung cancer among cobalt-exposed women

Tüchsen¹,

Jensen²,

Villadsen³

et al. 1996

Scand J Work Environ Health

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Objectives The purpose of this study was to estimate the risk of lung cancer for women occupationally exposed to cobalt-aluminate spinel. Methods A retrospective cohort of 874 women occupationally exposed to cobalt in two Danish porcelain factories and 520 woinen not exposed to cobalt were identified from personnel files. Vital status was assessed in the national population register, and incident cancer cases were traced in the national cancer register. Thirteen women (0.92%) were lost to follow-up. The observed deaths and incident cancer cases were cornpared with the expected number based on rates for all Danish women. Results The total mortality of the cohort was the same as for all Danish women. The incidence of all cancer was slightly elevated among the exposed women (67 observed, 55.8 expected) and equal to the expected in the reference group (60 observed, 60.6 expected). An increased lung cancer incidence was found both in the exposed group [8 cases, standardized incidence rate (SIR) 2.35, 95% confidence interval (95% CI) 1.014.61 and in the reference group (7 cases, SIR 1.99,95% CI 0 . 8 4 . 1 ) . The exposed group had a relative risk ratio of 1.2 (95% CI 0.4-3.8) when compared with the reference group. C O~C~U S~O~S Both the cobalt-exposed group and the reference group had an increased lung cancer risk compared with all Danish women, but the risk was only slightly higher for the exposed group than for the reference group. The study was based on few persons, and we recommend a follow-up after five years.

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Effect of occupational exposure to cobalt blue dyes on the thyroid volume and function of female plate painters.

Cited by 39 publications

References 14 publications

Systemic cobalt toxicity from total hip arthroplasties

Systemic cobalt toxicity from total hip arthroplasties

Orthopaedic metals and their potential toxicity in the arthroplasty patient

Incidence of lung cancer among cobalt-exposed women

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