Incidence of lung cancer among cobalt-exposed women

Tüchsen, Finn; Jensen, Marianne V; Villadsen, Ebbe; Lynge, Elsebeth

doi:10.5271/sjweh.166

Cited by 21 publications

(8 citation statements)

References 15 publications

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“…Although evidence of increase in Co in relation to oral cancer is lacking, increase in concentration of Co has been noted in other epithelial malignancy [35].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Trace Elemental Profiles in Blood Samples of Indian Patients with Leukoplakia and Oral Submucous Fibrosis

Ray

Ghosh

Mallick

et al. 2011

Biol Trace Elem Res

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In order to ascertain possible correlation between alterations in trace elemental profile and the progression or regression of two most common potentially malignant disorders affecting oral cavity, namely oral submucous fibrosis and leukoplakia, blood from 60 patients from each group of patients as well from 30 healthy individuals was analyzed for elemental profiling employing EDXRF technique. Out of the 16 detected elements (K, Si, Ca, V, Cr, Ni, Mn, Fe, Cu, Zn, Se, Br, Rb, Sr, Co, and Pb), Mn, Fe, Zn, Br, and Co showed remarkable alteration in their profile in both leukoplakia and oral submucous fibrosis patients with respect to the normal healthy individuals. While Zn, Br, and Fe reflected similar changes--showing gross depletion in both the diseased groups, Mn and Co depicted inverse pattern of alterations in their concentrations in the two types of precancerous disorders when compared to the control subjects.

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“…Although evidence of increase in Co in relation to oral cancer is lacking, increase in concentration of Co has been noted in other epithelial malignancy [35].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Trace Elemental Profiles in Blood Samples of Indian Patients with Leukoplakia and Oral Submucous Fibrosis

Ray

Ghosh

Mallick

et al. 2011

Biol Trace Elem Res

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“…A Scandinavian study comparing 874 female porcelain factory cobalt-painting workers with Danish women in general revealed little or no increased incidence of cancer (Tuchsen et al 1996). Another study (Christensen and Poulsen 1994) monitored plate painters who used soluble and insoluble cobalt between 1982 and 1992 in Denmark.…”

Section: Effects On Microorganisms Plants Animals and Humansmentioning

confidence: 99%

Cobalt

Schrauzer

2004

Elements and Their Compounds in the Environment

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“…A mortality study was conducted among Danish women exposed to poorly soluble cobalt-aluminate spinel in a porcelain factory 36. The airborne cobalt concentrations in this plant were high (often >1000 μg/m 3 ).…”

Section: Other Cobalt Compoundsmentioning

confidence: 99%

Update on the genotoxicity and carcinogenicity of cobalt compounds

Boeck²,

et al. 2001

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Objective-To integrate recent understandings of the mechanisms of genotoxicity and carcinogenicity of the diVerent cobalt compounds. Method-A narrative review of the studies published since the last IARC assessment in 1991 (genotoxicity, experimental carcinogenesis, and epidemiology). Results-Two diVerent mechanisms of genotoxicity, DNA breakage induced by cobalt metal and especially hard metal particles, and inhibition of DNA repair by cobalt (II) ions contribute to the carcinogenic potential of cobalt compounds. There is evidence that soluble cobalt (II) cations exert a genotoxic and carcinogenic activity in vitro and in vivo in experimental systems but evidence in humans is lacking. Experimental data indicate some evidence of a genotoxic potential for cobalt metal in vitro in human lymphocytes but there is no evidence available of a carcinogenic potential. There is evidence that hard metal particles exert a genotoxic and carcinogenic activity in vitro and in human studies, respectively. There is insuYcient information for cobalt oxides and other compounds. Conclusion-Although many areas of uncertainty remain, an assessment of the carcinogenicity of cobalt and its compounds requires a clear distinction between the diVerent compounds of the element and needs to take into account the diVerent mechanisms involved. (Occup Environ Med 2001;58:619-625) Keywords: cobalt; DNA breakage; inhibition of DNA repair Cobalt and several of its compounds are used in various industrial applications (table 1). Workers are mainly exposed to cobalt by inhalation and varying toxic manifestations aVecting the respiratory system have been reported in these industries. Diseases of the upper respiratory tract, the bronchial tree, and the lung parenchyma have been reported and reviewed.

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Incidence of lung cancer among cobalt-exposed women

Cited by 21 publications

References 15 publications

Correlation of Trace Elemental Profiles in Blood Samples of Indian Patients with Leukoplakia and Oral Submucous Fibrosis

Correlation of Trace Elemental Profiles in Blood Samples of Indian Patients with Leukoplakia and Oral Submucous Fibrosis

Cobalt

Update on the genotoxicity and carcinogenicity of cobalt compounds

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