Effect of obesity, glucose control, lipid profiles, and blood pressure on Lp-PLA2 levels in type 2 diabetes mellitus patients

Kurniawan, Liong Boy; Rampo, Herniaty; Soraya, Gita Vita; Adnan, Endy; Esa, Tenri; Widaningsih, Yuyun; Bahrun, Uleng; Arif, Mansyur

doi:10.1016/j.obmed.2021.100318

Cited by 4 publications

(10 citation statements)

References 21 publications

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“…Given the effect size, a minimum sample size of 1966 was required to achieve a type I error of 1% and power of 99%. 12 The basic characteristics of male and female subjects were compared using an independent sample t-test for continuous variables or the chi-square test for categorical variables. We further compared the Lp-PLA 2 level of subjects according to the presence or absence of comorbidities (hypertension, diabetes, MetS, and weight status) using an independent sample t-test in the whole cohort and after stratifying by sex.…”

Section: Methodsmentioning

confidence: 99%

“… 9 Since Lp-PLA 2 activity is positively associated with LDL and adiposity 10 that helps predict the risk of atherosclerosis and cardiovascular disease. 11 Lp-PLA 2 had significant positive correlation with systolic, diastolic, mean arterial pressure (MAP), total cholesterol, LDL, plasma glucose, and HbA1c 12 as well, so it may be a proper predictor for obesity.…”

Section: Introductionmentioning

confidence: 97%

“…Lp-PLA 2 is a novel inflammatory biomarker of cardiovascular disorders in metabolic diseases 12 that can provide important information about plaque inflammation and stability 16 and is also the main cause of coronary artery disease. The United States Food and Drug Administration approved Lp-PLA 2 as a predictor of coronary artery disease using the PLAC Test ELISA kit on December 2014.…”

Section: Introductionmentioning

confidence: 99%

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The correlation between lipoprotein associated phospholipase A₂ and central overweight status

Chen

et al. 2021

Int J Immunopathol Pharmacol

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Objective: Being overweight is associated with an increased risk of diabetes mellitus, hypertension, and cardiovascular disease. Lipoprotein-associated phospholipase A2 (Lp-PLA2) can independently predict the risk of cardiovascular disease. This study is aimed to investigate whether Lp-PLA2 was associated with an overweight status. Methods: This was a cross-sectional study that enrolled 3760 Chinese adults (age, 18–50 years) who underwent medical examination department of Xiamen Chang-Gung Hospital (XCGH) from 2018 to 2020. To explore the distribution of overweight classifications in the Chinese population, we evaluated the correlation of the overweight status with Lp-PLA2, after correcting for possible influencing factors. Results: The Lp-PLA2 level was greater in male than in female subjects ( p < 0.001). Subjects with a central overweight status had a greater Lp-PLA2 level than those with normal weight and a peripheral overweight status, in both male and female cohorts. The Lp-PLA2 level was significantly greater in those with additional comorbidities (namely diabetes mellitus (DM), hypertension (HTN), overweight, and metabolic syndrome (MetS)). The age-adjusted and LDL-adjusted Lp-PLA2 level also was significantly higher in the DM (+) and HTN (−) subgroups than in the DM (−), HTN (−), DM (−), and HTN (+) subgroups. Conclusion: Lp-PLA2 is associated with sex, central overweight status, diabetes, hypertension, and MetS in adults aged < 50 years and the age-adjusted and LDL-adjusted Lp-PLA2 was significantly higher in the DM (+) and HTN (−) subgroups than in the DM (−) and HTN (−) and DM (−) and HTN (+) subgroups.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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The correlation between lipoprotein associated phospholipase A₂ and central overweight status

Chen

et al. 2021

Int J Immunopathol Pharmacol

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“…A recent study, in which the participants were grouped according to sex, revealed that Lp-PLA2 has a greater association with body fat and mean arterial pressure in males, whereas a greater association with LDL-C and TG was seen in females [ 19 ]. These results are only partially consistent with our findings in which blood pressure exhibited a significant relationship with Lp-PLA2 only in young men, whereas LDL-C, TG, and HDL-C levels were significantly related to Lp-PLA2 levels in all groups, regardless of sex or age.…”

Section: Discussionmentioning

confidence: 99%

“…According to a previous study investigating the relationship between LDL-C and the Lp-PLA2 level in type II diabetic patients, the standardized regression coefficient of LDL-C was 0.11 [ 19 ]. Given the effect size, a minimum sample size of 1063 in each of the subgroups was required to achieve a type I error of 5% and power of 95%.…”

Section: Methodsmentioning

confidence: 99%

Age- and Sex-Specific Association between Lipoprotein-Related Phospholipase A2 and Cardiometabolic Risk Factors

Chen

et al. 2023

IJMS

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(1) Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a risk factor for predicting cardiovascular diseases. Metabolic syndrome is characterized by a state of chronic inflammation that is related to an increased risk of cardiovascular events and death. In the present study, we aimed to analyze the correlation between cardiometabolic risk factors and Lp-PLA2 levels. (2) We collected the related retrospective medical data of Chinese adults, of which 3983 were men and 2836 were women (aged ≥ 18 years), who underwent health check-ups, and discussed the sex and age-related differences. (3) Data analysis showed that Lp-PLA2 was significantly related to lipoproteins and glutamic pyruvic transaminase (GPT), and that a linear trend was observed with increasing Lp-PLA2 levels for all ages and sexes. However, fasting glucose was significantly related to Lp-PLA2 only in the younger population. The two obesity-related parameters (waist-to-height ratio and waist circumference) also had a greater correlation with Lp-PLA2 levels in the younger groups; however, the correlation weakened in the elderly population. Meanwhile, the correlation between mean arterial pressure and creatinine level and Lp-PLA2 was significant only in younger men. (4) The results show that the expression patterns of Lp-PLA2 differ between sexes and across age groups.

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Effect of probiotic supplementation on lipoprotein-associated phospholipase A2 in type 2 diabetic patients: a randomized double blind clinical controlled trial

Jaff,

Gubari,

Shab-Bidar

et al. 2024

Nutr Metab (Lond)

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Background It has been recently reported that lipoprotein-associated phospholipase A2 (Lp-PLA2) may predict the risk of cardiovascular disease. The effect of multi-strain probiotics on Lp-PLA2 in patients with type 2 diabetes is still not clear. Aims This study aimed to determine the effect of multi-strain probiotic supplementation on lipoprotein-associated phospholipase A2, and glycemic status, lipid profile, and body composition in patients with type 2 diabetes. Methods In this randomized double-blind placebo-controlled clinical trial, 68 participants with type 2 diabetes, in the age group of 50–65 years, were recruited and randomly allocated to take either probiotic (n = 34) or placebo (n = 34) for 12 weeks. The primary outcome was lipoprotein-associated phospholipase A2, and secondary outcomes were glycemic parameters, lipid profile, anthropometric characters, and body composition (fat mass and fat-free mass). Results There was a significant reduction in serum lipoprotein-associated phospholipase A2, in the probiotic group, it dropped by 6.4 units at the end of the study (p < 0.001) compared to the placebo group. Probiotic supplementation also resulted in a significant improvement in the hemoglobin A1c and high-density lipoprotein cholesterol 1.5% (p < 0.001) and 6 mg/dl (p 0.005), respectively. There were no significant changes in other outcomes. Conclusion Probiotic supplementation was beneficial for reducing Lp-PLA2 and hemoglobin-A1c and improving high-density lipoprotein cholesterol, which may suggest an improvement in the prognosis in patients with type 2 diabetes.

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Effect of obesity, glucose control, lipid profiles, and blood pressure on Lp-PLA2 levels in type 2 diabetes mellitus patients

Cited by 4 publications

References 21 publications

The correlation between lipoprotein associated phospholipase A₂ and central overweight status

The correlation between lipoprotein associated phospholipase A₂ and central overweight status

Age- and Sex-Specific Association between Lipoprotein-Related Phospholipase A2 and Cardiometabolic Risk Factors

Effect of probiotic supplementation on lipoprotein-associated phospholipase A2 in type 2 diabetic patients: a randomized double blind clinical controlled trial

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Effect of obesity, glucose control, lipid profiles, and blood pressure on Lp-PLA2 levels in type 2 diabetes mellitus patients

Cited by 4 publications

References 21 publications

The correlation between lipoprotein associated phospholipase A2 and central overweight status

The correlation between lipoprotein associated phospholipase A2 and central overweight status

Age- and Sex-Specific Association between Lipoprotein-Related Phospholipase A2 and Cardiometabolic Risk Factors

Effect of probiotic supplementation on lipoprotein-associated phospholipase A2 in type 2 diabetic patients: a randomized double blind clinical controlled trial

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The correlation between lipoprotein associated phospholipase A₂ and central overweight status

The correlation between lipoprotein associated phospholipase A₂ and central overweight status