The correlation between lipoprotein associated phospholipase A₂ and central overweight status

Abstract

Objective: Being overweight is associated with an increased risk of diabetes mellitus, hypertension, and cardiovascular disease. Lipoprotein-associated phospholipase A2 (Lp-PLA2) can independently predict the risk of cardiovascular disease. This study is aimed to investigate whether Lp-PLA2 was associated with an overweight status. Methods: This was a cross-sectional study that enrolled 3760 Chinese adults (age, 18–50 years) who underwent medical examination department of Xiamen Chang-Gung Hospital (XCGH) from 2018 to 2020. To explore the distribution of overweight classifications in the Chinese population, we evaluated the correlation of the overweight status with Lp-PLA2, after correcting for possible influencing factors. Results: The Lp-PLA2 level was greater in male than in female subjects ( p < 0.001). Subjects with a central overweight status had a greater Lp-PLA2 level than those with normal weight and a peripheral overweight status, in both male and female cohorts. The Lp-PLA2 level was significantly greater in those with additional comorbidities (namely diabetes mellitus (DM), hypertension (HTN), overweight, and metabolic syndrome (MetS)). The age-adjusted and LDL-adjusted Lp-PLA2 level also was significantly higher in the DM (+) and HTN (−) subgroups than in the DM (−), HTN (−), DM (−), and HTN (+) subgroups. Conclusion: Lp-PLA2 is associated with sex, central overweight status, diabetes, hypertension, and MetS in adults aged < 50 years and the age-adjusted and LDL-adjusted Lp-PLA2 was significantly higher in the DM (+) and HTN (−) subgroups than in the DM (−) and HTN (−) and DM (−) and HTN (+) subgroups.

Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A2 activity and traditional cardiovascular risk factors

“…There was a positive correlation between blood pressure and Lp‐PLA 2 , no correlation between Lp‐PLA 2 and BMI, and only a small positive correlation with waist circumference with previous research reporting similar results 57,90,91 . However, a strong correlation was reported between Lp‐PLA 2 and central obesity in a Chinese population 92 …”

“…57,90,91 However, a strong correlation was reported between Lp-PLA 2 and central obesity in a Chinese population. 92 The negative correlation between systolic blood pressure and PAF may be expected as animal studies show PAF induces systemic hypotension 93,94 and in humans, some biological actions of PAF include inducing vascular hyper-permeability and hypotension. 95 The current study found a medium negative correlation between PAF and both waist circumference and BMI.…”

Association of High‐Sensitivity C‐Reactive Protein and Lipoprotein‐Associated Phospholipase A2 with Metabolically Unhealthy Phenotype: A Cross Sectional Study

“… 32 Another study suggests that subjects with a central overweight status have a greater Lp-PLA2 level than those with normal weight and a peripheral overweight status. 33 The results illustrate that the association between Lp-PLA2 and different obesity indicators and the potential mechanisms deserve further investigation.…”

“…32 Another study suggests that subjects with a central overweight status have a greater Lp-PLA2 level than those with normal weight and a peripheral overweight status. 33 The results illustrate that the association between Lp-PLA2 and different obesity indicators and the potential mechanisms deserve further investigation. Next, we found that the combination of hs-CRP and Lp-PLA2 levels was significantly correlated with metabolic unhealthy in non-obese subjects, and the significant association was still present even after was still exist even after being adjusted for multi-variables, suggesting that combined hs-CRP and Lp-PLA2 was an independent risk factor for metabolic unhealthy in non-obese subjects.…”

Correlation Between Lipoprotein-Related Phospholipase A2 and Metabolic Syndrome

“… 13 Similarly, a study conducted among adults showed a significant association between central obesity, represented by higher waist circumference, and Lp-PLA2 levels. 14 Hence, the correlation between waist circumference and Lp-PLA2 level may be applicable to all age groups. Additionally, our study found that WHtR had a significant association with Lp-PLA2 by gender.…”