Effect of Nonionic Surfactants on Percutaneous Absorption of Salicylic Acid and Sodium Salicylate in the Presence of Dimethyl Sulfoxide

Shen, Wu-Wei; Danti, August G.; Bruscato, Frank N.

doi:10.1002/jps.2600651222

Cited by 41 publications

(19 citation statements)

References 3 publications

(2 reference statements)

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“…Percutaneous absorption of salicylic acid (15) and flufenamic acid (4) were increased significantly when Span 40 or Span 85 was added to the ointment containing dimethyl sulfoxide and percutaneous absorption of sodium salicylate was increased by Span 20 or Span 311 40. Span 20, 80 and 85 enhanced naloxone flux through human skin (9).…”

Section: Discussionmentioning

confidence: 96%

Surfactant effects on the in vitro percutaneous absorption of diclofenac sodium

Arellano

Santoyo

Martn

et al. 1998

European Journal of Drug Metabolism and Pharmacokinetics

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Nonionic surfactants, which are a safe class of enhancers, may offer means of enhancing drug permeation through the skin. In order to determine this effect, the influence of four nonionic surfactants on the percutaneous absorption of diclofenac sodium from carbopol gels containing 40% propylene glycol was investigated. In vitro diffusion experiments were carried out using excised full-thickness abdominal rat skin as well as cellulose nitrate membranes. The data of this study clearly revealed that Tween 80 decreased diclofenac penetration rate. This was due to a decrease in thermodynamic activity as a result of micellar complexation. In contrast, the more hydrophobic sorbitans enhanced diclofenac skin penetration, probably due to changes in the barrier properties of the skin and in the vehicle-stratum corneum partition coefficient. The most enhancing effect was induced by Span 20, a surfactant with a C12 saturated hydrophobic group. However, diffusional lag times for all the tested surfactants were longer than for the control gel.

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Section: Discussionmentioning

confidence: 96%

Surfactant effects on the in vitro percutaneous absorption of diclofenac sodium

Arellano

Santoyo

Martn

et al. 1998

European Journal of Drug Metabolism and Pharmacokinetics

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“…Several sub-classes of surfactants (e.g., anionic, cationic, and nonionic) have been studied in the context of transdermal permeation, and are believed to reversibly modify lipids by adsorption at interfaces and removal of water-soluble agents that act as plasticizers [10, 11]. Cationic surfactants are known to produce greater increases in permeant flux than anionic surfactants, which, in turn, increase permeability more than nonionic surfactants [12–14]. Cationic surfactants, however, are generally more damaging to the skin [13].…”

Section: Introductionmentioning

confidence: 99%

Effect of Chemical Permeation Enhancers on Nerve Blockade

et al. 2008

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Chemical permeation enhancers (CPEs) have the potential to improve access of local anesthetics to the nerve, thereby improving nerve block performance. We assessed the effects of six CPEs on nerve blockade from tetrodotoxin (TTX) and from bupivacaine. Each of the six surfactants, representing three CPE sub-groups (anionic, cationic, and nonionic surfactants) was co-injected with TTX or bupivacaine at the sciatic nerve of Sprague-Dawley rats. Myotoxicity of CPEs, alone and with TTX, was assessed in vitro in C2C12 myotubes and in vivo via histological analysis. All enhancers produced marked concentration-dependent improvements in the frequency and duration of block with TTX but not bupivacaine. An in vitro toxicity assay showed a wide range of CPE myotoxicity, but in vivo histological assessment showed no signs of muscle or nerve damage at concentrations of CPEs that produced a half-maximal increase in the duration of block of TTX (except in the case of the cationic surfactant DDAB). This study demonstrates that CPEs can provide marked prolongation of nerve blockade from TTX but not bupivacaine, without apparent local tissue toxicity. These results may enhance the clinical applicability of TTX for prolonged-duration local anesthesia.

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“…[35] Sorbitan monopalmitate, sorbitan trioleate, polyoxyl 8 stearate, polyoxyethylene 20 cetyl ether, or polyoxyethylene 2 oleyl ether 10% (w/w) significantly enhanced the percutaneous absorption of flufenamic acid and sodium salicylate when incorporated into white petrolatum USP ointment base. [3637]…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Status of surfactants as penetration enhancers in transdermal drug delivery

Som¹,

Bhatia²,

Yasir³

2012

J Pharm Bioall Sci

209

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Surfactants are found in many existing therapeutic, cosmetic, and agro-chemical preparations. In recent years, surfactants have been employed to enhance the permeation rates of several drugs via transdermal route. The application of transdermal route to a wider range of drugs is limited due to significant barrier to penetration across the skin which is associated with the outermost stratum corneum layer. Surfactants have effects on the permeability characteristics of several biological membranes including skin. They have the potential to solubilize lipids within the stratum corneum. The penetration of the surfactant molecule into the lipid lamellae of the stratum corneum is strongly dependent on the partitioning behavior and solubility of surfactant. Surfactants ranging from hydrophobic agents such as oleic acid to hydrophilic sodium lauryl sulfate have been tested as permeation enhancer to improve drug delivery. This article reviews the status of surfactants as permeation enhancer in transdermal drug delivery of various drugs.

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Effect of Nonionic Surfactants on Percutaneous Absorption of Salicylic Acid and Sodium Salicylate in the Presence of Dimethyl Sulfoxide

Cited by 41 publications

References 3 publications

Surfactant effects on the in vitro percutaneous absorption of diclofenac sodium

Surfactant effects on the in vitro percutaneous absorption of diclofenac sodium

Effect of Chemical Permeation Enhancers on Nerve Blockade

Status of surfactants as penetration enhancers in transdermal drug delivery

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