Effect of non‐invasive tear stability assessment on tear meniscus height

Abstract

ABSTRACT.Purpose: To investigate the effect of non-invasive tear stability assessment with forced eye opening on the lower tear meniscus. Methods: Twenty-three eyes of 23 patients with aqueous-deficient dry eye and 23 eyes of 23 normal subjects were enrolled. All subjects underwent imaging with a Keratograph 5M equipped with a modified tear film scanning function. Lower tear meniscus images were captured, and tear meniscus height (TMH) was measured with an integrated ruler before and after non-invasive Keratograph break-up time (NIKBUT) measurements in each subject. Subjects were instructed to keep their eyes open as long as possible during NIKBUT measurements, and the recording was discontinued at the next blink. Results:The TMH values of the normal and dry eye groups were 0.20 AE 0.05 mm and 0.14 AE 0.03 mm, respectively, at baseline. The TMH values of dry eyes were significantly smaller than those of normal eyes (p < 0.001). Significant increases in TMH values were observed in both normal (0.10 AE 0.12 mm) and dry eyes (0.04 AE 0.09 mm) with the NIKBUT measurement (p < 0.001, p = 0.039). A moderate negative correlation was observed between increased TMH and baseline TMH in dry eyes (r = À0.44, p = 0.03), whereas no correlation was observed in normal eyes (r = 0.04, p = 0.85). Conclusions: Forced eye opening required for the non-invasive tear stability assessment influences the TMH measurement possibly due to reflex tear secretion, even in patients with aqueous-deficient dry eye. TMH should be assessed before tests that require forced eye opening.

Bilateral tear film alterations in patients with unilateral quiescent herpes simplex keratitis

“…The sample size was small, and the Cochet-Bonnet esthesiometer is not sensitive enough in the measurement of corneal sensitivity. In addition, the Schirmer's I test in our study is an invasive test that is low on the reproductive and sensitive scale for diagnosing dry eye (Koh et al 2015). Noninvasively evaluate of tear film such as ultra-high-resolution optical coherence tomography could be considered in our further study (Kaya et al 2015).…”

Comparison of Tear Meniscus Height Measurements Obtained With the Keratograph and Fourier Domain Optical Coherence Tomography in Dry Eye

“…TMH measurement with the keratograph is essentially the same as photographing with a slit lamp 3 but has several advantages including a short evaluation time and using infrared diodes as a light source, which prevents reflex tearing and negates the need for fluorescein instillation or calibration of magnification. In a recent study of the effect of noninvasive tear stability assessment on the TMH using the keratograph, 27 the TMH values of the normal and dry eye groups were 0.20 and 0.14 mm, respectively, and the values increased to 0.30 and 0.18 mm, respectively, after the measurement of TBUT. Our result was 0.23 mm in patients with dry eye, which is higher than that seen in the aforementioned study.…”

Correlation of vitamin D levels with tear film stability and secretion in patients with dry eye syndrome

“…; Koh et al. ). Further study using these non‐invasive methods could be useful to evaluate the effect of vitamin D on DES.…”