Correlation of vitamin D levels with tear film stability and secretion in patients with dry eye syndrome

Jin, Ki Won; Ro, Jin Woo; Shin, Young Joo; Hyon, Joon Young; Wee, Won Ryang; Park, Shin Goo

doi:10.1111/aos.13241

Cited by 49 publications

(49 citation statements)

References 47 publications

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“…Vitamin D is a potent antioxidant, and patients with increased levels of serum vitamin D levels were found to have increased BUT and tear secretion (Jin et al. ). Serum vitamin D levels are positively correlated to tear vitamin D levels, with tear vitamin D levels being higher than that of serum levels (Sethu et al.…”

Section: Future Studies and Challengesmentioning

confidence: 99%

“…The importance of vitamin C supplementation for the health of the ocular surface and tear has been shown in diabetic people, who are at risk for dry eye (Peponis et al 2002(Peponis et al , 2004. Vitamin D is a potent antioxidant, and patients with increased levels of serum vitamin D levels were found to have increased BUT and tear secretion (Jin et al 2017). Serum vitamin D levels are positively correlated to tear vitamin D levels, with tear vitamin D levels being higher than that of serum levels (Sethu et al 2016).…”

Section: Future Studies and Challengesmentioning

confidence: 99%

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Dry eye disease and oxidative stress

Seen

Tong

2017

Acta Ophthalmologica

220

162

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Dry eye, an age-related condition, is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance and tear film instability. Environmental factors are also often implicated in dry eye including exposure to pollutants, ultraviolet (UV) radiation and ozone as well as the chronic use of preserved eyedrops such as in the treatment of glaucoma. These factors increase oxidative stress and ocular surface inflammation. Here, we reviewed the cellular, animal and clinical studies that point to the role of oxidative stress in dry eye disease. The biomarkers used to indicate oxidative damage in ocular surface tissues include 8-hydroxy-2 deoxyguanosine (8-OHdG), 4-hydroxynonenal (HNE) and malondialdehyde (MDD). Antioxidative defences in the ocular surface occur in the form of tear proteins such as lactoferrin and S100A proteins, and enzymes such as superoxide dismutase (SOD), peroxidase, catalase and mitochondrial oxidative enzymes. An imbalance between the level of reactive oxygen species (ROS) and the action of protective enzymes will lead to oxidative damage, and possibly inflammation. A small number of interventional studies suggest that oxidative stress may be directly targeted in topical therapy of dry eye treatment. For example, in vitro studies suggest that L-carnitine and pterostilbene, a blueberry component may reduce oxidative stress, and in animal studies, alpha-lipoic acid (ALP) and selenoprotein P may be helpful. Examples of treatments used in clinical trials include vitamin B12 eyedrops and iodide iontophoresis. With recent emphasis on ageing medicine and preventive holistic health, as well as the role of environmental science, research on oxidative stress in the ocular surface is likely to have increasing impact in the coming years.

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Section: Future Studies and Challengesmentioning

confidence: 99%

Section: Future Studies and Challengesmentioning

confidence: 99%

Dry eye disease and oxidative stress

Seen

Tong

2017

Acta Ophthalmologica

220

162

View full text Add to dashboard Cite

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“…Essential fatty acids should be considered for routine use in SM-exposed victims. Jin et al [2016] reported that tear secretion and tear film break-up time are associated with the serum level of vitamin D, and thus the deficiency of this vitamin plays an important role in dry eye patients. Oral administration of pilocarpine and cevimeline is documented in dry eye patients [Ono et al, 2004;Kawakita et al, 2015], results in increase of tear film break-up time, improve healing of corneoconjunctival epithelium, and decrease in ocular symptoms [Ono et al, 2004;Kawakita et al, 2015].…”

Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 99%

“…The direct effect of vitamin D in dry eye management is controversial. Jin et al [2016] reported that tear secretion and tear film break-up time are associated with the serum level of vitamin D, and thus the deficiency of this vitamin plays an important role in dry eye patients. Jee et al [2016] did not support these findings and showed that vitamin D is more effective in the management of macular disease and diabetic retinopathy than dry eye disease.…”

Section: Medical Managementsmentioning

confidence: 99%

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Panahi

Rajaee

Sahebkar

2017

J of Cellular Biochemistry

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Sulfur mustard (SM) is a strong blistering, highly reactive, lipophilic chemical war agent that causes injury in different organs including the skin, eyes, and respiratory tract. The Eyes are especially susceptible to the consequences of SM poisoning because of the aqueous and mucosal nature of conjunctiva and cornea. DNA alkylation and depletion of glutathione, are the most important mechanisms of SM action in the eye injuries. Acute clinical symptoms are including decrease in visual acuity, dryness, photophobia, blepharospasm, conjunctivitis, and complaints of foreign body sensation and soreness that gradually progress to severe ocular pain. Corneal abrasions, ulcerations, vesication, and perforations are common corneal consequences in SM injured victims. Appearance of chronic symptoms has been reported as chronic inflammation of the corneal and conjunctival vasculature, ischemia, lipid and cholesterol deposition, scarring in cornea, corneal thinning, opacification and perforation of the cornea, limbal stem cell deficiency (LSCD), and neovascularization. Different medical and surgical protocols have been documented in the management of SM-induced ocular injuries, including preservative-free artificial tears, topical steroids and antibiotic, mydriatic, antiglaucoma drops, therapeutic contact lenses, dark glasses and punctal plugs/cauterization, N-acetylcysteine, tarsorrhaphy, amniotic membrane transplantation, stem cell transplantation, and corneal transplantation. New drugs such as resolvin E1, topical form of essential fatty acids, thymosin β4, 43 amino-acid polypeptides, topical form of curcumin, newly formulated artificial tears, diquafosol, rebamipide, tretinoin, and oral uridineseems to be beneficial in the management of ocular lesion associated with sulfur mustard poisoning. Further studies are needed to approve these drugs in SM victims. J. Cell. Biochem. 118: 3549-3560, 2017. © 2017 Wiley Periodicals, Inc.

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“…For example, Jee et al (2016) reported no effect, whereas Yildirim et al (2016) and Kurtul (2015b) suggested good improvements. Jin et al (2016) observed that TBUT was shorter in people with vitamin D deficiency, but did not measure a significant impact on OSDI scores or fluorescein staining (Jin et al, 2016).…”

Section: Impact Of Vitamin D Supplements On Dry Eyementioning

confidence: 96%

Vitamin D in Dry Eye and Myopia

Yang¹

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Correlation of vitamin D levels with tear film stability and secretion in patients with dry eye syndrome

Abstract: Tear break-up time (TBUT) and secretion were correlated with serum vitamin D levels. Vitamin D status may be an important factor for dry eye syndrome.

Cited by 49 publications

References 47 publications

Dry eye disease and oxidative stress

Dry eye disease and oxidative stress

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Vitamin D in Dry Eye and Myopia

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