Effect of Noisy Galvanic Vestibular Stimulation on Ocular Vestibular-Evoked Myogenic Potentials to Bone-Conducted Vibration

Iwasaki, Shinichi; Karino, Shotaro; Kamogashira, Teru; Togo, Fumiharu; Fujimoto, Chisato; Yamamoto, Yoshiharu; Yamasoba, Tatsuya

doi:10.3389/fneur.2017.00026

Cited by 30 publications

(18 citation statements)

References 30 publications

(42 reference statements)

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“…Currently, the therapeutic regime in individuals with BVH is limited to physical therapy ( 39 ), where approximately only half of these patients benefit from this kind of intervention ( 40 ). The findings we report in this study, together with previous reports on nGVS-induced improvements in balance control as well as ocular-motor function ( 41 ) can promote an alternative or additional therapeutic option for reducing the postural imbalance and incidence of falls in this population.…”

Section: Discussionsupporting

confidence: 78%

Noisy Galvanic Stimulation Improves Roll-Tilt Vestibular Perception in Healthy Subjects

Keywan¹,

Wuehr²,

Pradhan³

et al. 2018

Front. Neurol.

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It has recently been demonstrated that noisy galvanic vestibular stimulation (nGVS) delivered as imperceptible white noise can improve balance control via the induction of stochastic resonance. However, it is unclear whether these balance improvements are accompanied by simultaneous enhancement to vestibular motion perception. In this study, 15 healthy subjects performed 8 quiet-stance tasks on foam with eyes closed at 8 different nGVS amplitudes ranging from 0 mA (baseline) to 0.5 mA. The nGVS amplitude that improved balance performance most compared to baseline was assigned as the optimal nGVS amplitude. Optimal nGVS amplitudes could be determined for 13 out of 15 subjects, who were included in the subsequent experimental procedures. The effect of nGVS delivered at the determined optimal intensity on vestibular perceptual thresholds was examined using direction-recognition tasks on a motion platform, testing roll rotations at 0.2, 0.5, and 1.0 Hz, both with active and sham nGVS stimulations. nGVS significantly reduced direction-recognition thresholds compared to the sham condition at 0.5 and 1.0 Hz, while no significant effect of nGVS was found at 0.2 Hz. Interestingly, no correlation was found between nGVS-induced improvements in balance control and vestibular motion perception at 0.5 and 1 Hz, which may suggest different mechanisms by which nGVS affects both modalities. For the first time, we show that nGVS can enhance roll vestibular motion perception. The outcomes of this study are likely to be relevant for the potential therapeutic use of nGVS in patients with balance problems.

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Section: Discussionsupporting

confidence: 78%

Noisy Galvanic Stimulation Improves Roll-Tilt Vestibular Perception in Healthy Subjects

Keywan¹,

Wuehr²,

Pradhan³

et al. 2018

Front. Neurol.

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“…Studies have shown that patients with vestibular disorders have increased COP sway path lengths and mean velocities [ 21 ] and that nGVS can enhance the function of vestibular afferents [ 22 ]. These findings suggest that the improved function of vestibular afferents may have reduced COP sway observed in this study.…”

Section: Discussionmentioning

confidence: 99%

“…These findings suggest that the improved function of vestibular afferents may have reduced COP sway observed in this study. The rationale for these ameliorating effects of nGVS is considered to be stochastic resonance [ 22 ], a phenomenon where a signal that is too weak to exceed a given threshold is amplified by adding noise. Stochastic resonance appears to enhance information processing in the sensory system [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of noisy galvanic vestibular stimulation in community-dwelling elderly people: a randomised controlled trial

Inukai

Masaki

Otsuru

et al. 2018

J NeuroEngineering Rehabil

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BackgroundBalance disorders are a risk factor for falls in the elderly. Although noisy galvanic vestibular stimulation (nGVS) has been reported to improve balance in young people, randomised control trials targeting community-dwelling elderly people have not been conducted to date. We aimed to assess the influence of nGVS on COP sway in the open-eye standing posture among community-dwelling elderly people in a randomised controlled trial.MethodsA randomised controlled trial of 32 community-dwelling elderly people randomly assigned to control (sham stimulation) and an nGVS groups. All participants underwent centre of pressure (COP) sway measurements while standing with open eyes at baseline and during stimulation. The control group underwent sham stimulation and the nGVS group underwent noise stimulation (0.4 mA; 0.1–640 Hz).ResultsIn the nGVS group, sway path length, mediolateral mean velocity and anteroposterior mean velocity decreased during stimulation compared with baseline (P < 0.01). The effect of nGVS was large in participants with a high COP sway path length at baseline, but there was no significant difference in COP sway in the control group.ConclusionsWe conclude that nGVS decreases the COP sway path length and mean velocity of community-dwelling elderly people when standing with open eyes. This suggests that nGVS could be effective for treating balance dysfunction in the elderly.

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“…We have previously shown that a 30-s application of nGVS can improve postural stability in healthy subjects and in BV patients ( 12 ). nGVS also enhances the vestibulo-ocular reflex in healthy subjects ( 13 ) and the vestibulo-spinal reflex in healthy subjects and BV patients ( 14 ). Moreover, nGVS improves walking stability in healthy subjects and BV patients ( 15 – 17 ).…”

Section: Introductionmentioning

confidence: 99%

Noisy Galvanic Vestibular Stimulation Sustainably Improves Posture in Bilateral Vestibulopathy

et al. 2018

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Patients with bilateral vestibulopathy (BV) suffer from persistent postural imbalance, leading to a marked decrease in quality of life and a higher risk of falls. However, so far, the effective treatments for BV are very limited. We examined whether long-term noisy galvanic vestibular stimulation (nGVS) keeps improving body balance after the cessation of the stimulus in BV patients. Thirteen BV patients received nGVS for 30 min with a lower intensity than the intensity at which they feel any cutaneous sensations, and their postural movement was monitored for 6 h after the stimuli. The same session was repeated at 14-day intervals. Stance tasks on two legs were performed with eyes closed. The velocity of the center of pressure (COP) movement, the area enclosed by the COP movement, and the root mean square of the displacement of the COP were measured. The power spectrum of the COP movement was assessed. Subjective improvement of body balance was graded as worsened (−2), slightly worsened (−1), unchanged (0), slightly improved (+1) and improved (+2) in comparison with that without nGVS. In each session, the velocity of the COP movement was significantly improved for 6 h after the stimulus had ceased (P < 0.01). Concomitantly, the mean frequency of the COP power spectrum was significantly reduced in the anterior-posterior axis (P < 0.05). Subjective symptoms of imbalance were improved during the post-stimulation effect (P < 0.05). nGVS leads to an improvement in body balance that lasts for several hours after the end of the stimulus in BV patients with a reduction in the high-frequency components of their postural movement. This trial was registered with the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMINCTR: UMIN000028054).

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Effect of Noisy Galvanic Vestibular Stimulation on Ocular Vestibular-Evoked Myogenic Potentials to Bone-Conducted Vibration

Cited by 30 publications

References 30 publications

Noisy Galvanic Stimulation Improves Roll-Tilt Vestibular Perception in Healthy Subjects

Noisy Galvanic Stimulation Improves Roll-Tilt Vestibular Perception in Healthy Subjects

Effect of noisy galvanic vestibular stimulation in community-dwelling elderly people: a randomised controlled trial

Noisy Galvanic Vestibular Stimulation Sustainably Improves Posture in Bilateral Vestibulopathy

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