Effect of noisy galvanic vestibular stimulation in community-dwelling elderly people: a randomised controlled trial

Inukai, Yasuto; Masaki, Mitsuhiro; Otsuru, Naofumi; Saito, Kei; Miyaguchi, Shota; Kojima, Sho; Onishi, Hideaki

doi:10.1186/s12984-018-0407-6

Cited by 39 publications

(58 citation statements)

References 37 publications

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“…First, nGVS was performed only with one stimulus intensity of 0.4 mA. We have reported that 0.4 mA nGVS is suitable for reducing COP sway in healthy young people and community-dwelling elderly people (Inukai et al, 2018a(Inukai et al, ,b, 2020. In this study, the COP sway post status did not decrease even if 0.4 mA nGVS was performed with closed-eyes standing position on a foam rubber.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Different Stimulation Conditions on the Stimulation Effect of Noisy Galvanic Vestibular Stimulation

Inukai

Miyaguchi

Saito

et al. 2020

Front. Hum. Neurosci.

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Balance disorders are a risk factor for falls in the elderly population. Balance control involving the complex interaction among nervous, muscular, and sensory systems should be maintained to keep an upright posture and prevent falls. Vestibular sensation is one of the main senses essential for postural control. Noisy galvanic vestibular stimulation (nGVS) is a noninvasive stimulation method for vestibular organs. Recently, it has received increasing attention for the treatment of balance disorders. However, the effect of balance disorders on stimulus effect during the implementation of nGVS remains unknown. Therefore, this study aimed to determine the effects of different floor surface and visual conditions on the stimulus effects of the nGVS intervention. In this study, two experiments were conducted with 24 participants (12 each for Experiments 1 and 2). In Experiment 1, nGVS (0.4 mA; 0.1-640 Hz) was performed in the open-eyes standing position on a solid surface (nGVS condition) and in the closed-eye standing position on a foam rubber (nGVS + foam rubber condition). In Experiment 2, sham stimulation was performed under the same conditions as in Experiment 1, except for nGVS. Center of pressure (COP) sway was measured in all participants with them standing with open eyes at Pre and Post-1 (immediately after the intervention) and Post-2 (10 min after the measurement of post-1). In Experiment 1, under the nGVS condition, COP sway was significantly reduced in Post-1 and Post-2 compared with Pre. However, no significant difference was observed among Pre, Post-1, and Post-2 under the nGVS + foam rubber condition. Furthermore, the intervention effect was significantly greater in the nGVS condition than in the nGVS + foam rubber condition. In contrast, in Experiment 2, the COP sway did not significantly differ among Pre, Post-1, and Post-2 under either condition. Based on the results of this study, nGVS was found to be effective with open-eyes standing on a solid surface.

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Section: Discussionmentioning

confidence: 99%

“…COP sway was measured for 30 s at 100 Hz in a standing position with legs together using a CFP400PA102RS (Leptrino, Nagano, Japan). Average COP sway path length, mediolateral (ML) mean velocity, and anteroposterior (AP) mean velocity were calculated (Inukai et al, 2018a(Inukai et al, ,b, 2020.…”

Section: Measurement Of Center Of Pressurementioning

confidence: 99%

Effects of Different Stimulation Conditions on the Stimulation Effect of Noisy Galvanic Vestibular Stimulation

Inukai

Miyaguchi

Saito

et al. 2020

Front. Hum. Neurosci.

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“…Recently, several groups of researchers have demonstrated that the application of subthreshold stochastic vestibular stimulation (SVS), also known as noisy galvanic vestibular stimulation, is associated with improved balance control during standing and changes in walking patterns [13][14][15][16][17][18][19][20]. For example, SVS results in reduced postural sway length and velocity during eyes-open quiet standing in young and older adults [15,16] and during eyes-closed quiet standing in patients with bilateral vestibulopathy [13,17]. In addition, others found increased gait speed and changes in stride measures with SVS during treadmill and overground walking in healthy adults and patients with bilateral vestibulopathy [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Subthreshold stochastic vestibular stimulation affects balance-challenged standing and walking

2020

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Subthreshold stochastic vestibular stimulation (SVS) is thought to enhance vestibular sensitivity and improve balance. However, it is unclear how SVS affects standing and walking when balance is challenged, particularly when the eyes are open. It is also unclear how different methods to determine stimulation intensity influence the effects. We aimed to determine (1) whether SVS affects stability when balance is challenged during eyes-open standing and overground walking tasks, and (2) how the effects differ based on whether optimal stimulation amplitude is derived from sinusoidal or cutaneous threshold techniques. Thirteen healthy adults performed balance-unchallenged and balance-challenged standing and walking tasks with SVS (0-30 Hz zero-mean, white noise electrical stimulus) or sham stimulation. For the balance-challenged condition, participants had inflatable rubber hemispheres attached to the bottom of their shoes to reduce the control provided by moving the center of pressure under their base of support. In different blocks of trials, we set SVS intensity to either 50% of participants' sinusoidal (motion) threshold or 80% of participants' cutaneous threshold. SVS reduced medial-lateral trunk velocity root mean square in the balance-challenged (p < 0.05) but not in the balance-unchallenged condition during standing. Regardless of condition, SVS decreased step-width variability and marginally increased gait speed when walking with the eyes open (p < 0.05). SVS intensity had minimal effect on the standing and walking measures. Taken together, our results provide insight into the effectiveness of SVS at improving balance-challenged, eyes-open standing and walking performance in healthy adults. OPEN ACCESSCitation: Piccolo C, Bakkum A, Marigold DS (2020) Subthreshold stochastic vestibular stimulation affects balance-challenged standing and walking. PLoS ONE 15(4): e0231334. https://doi.org/ 10.

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“…The third experiment, by performing an identical protocol but with the electrodes placed so that the vestibular apparatus was not stimulated, excluded the possibility that the effects seen with nGVS were due to motor learning, arousal, attention, or physical tension due to stimulation, as no change in COP sway path length was seen in this condition. In their RCT, Inukai et al (2018a) found results in agreement with Inukai et al (2018b), as the older adults randomized to the low-intensity condition demonstrated significantly reduced COP path length, as well as anteroposterior and mediolateral mean COP velocities, whereas the sham stimulation group showed no changes.…”

Section: Functional Effects Of Ngvs On Balancementioning

confidence: 70%

“…In this Neuro Forum, we discuss six recent articles (Inukai et al 2018a(Inukai et al , 2018bIwasaki et al 2018;Keywan et al 2018;Temple et al 2018;Wuehr et al 2018) that have explored the effects of nGVS on balance and gait in humans. Second, we discuss the potential mechanisms of the observed effects and, based on the current state of the art, give recommendations and directions for future research on nGVS for the purpose of improving balance and gait.…”

Section: Introductionmentioning

confidence: 99%

Stimulating balance: recent advances in vestibular stimulation for balance and gait

Herssens

McCrum

2019

Journal of Neurophysiology

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Noisy galvanic vestibular stimulation (nGVS) can boost vestibular sensory thresholds via stochastic resonance and research on nGVS as an intervention for vestibulopathy has accelerated recently. Recent research has investigated the effects and associated mechanisms of nGVS on balance and gait. nGVS has potential as an intervention for balance and gait-related deficits in vestibulopathy, but further research into the mechanisms underlying these effects and consensus on stimulation protocols are required.

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Effect of noisy galvanic vestibular stimulation in community-dwelling elderly people: a randomised controlled trial

Cited by 39 publications

References 37 publications

Effects of Different Stimulation Conditions on the Stimulation Effect of Noisy Galvanic Vestibular Stimulation

Effects of Different Stimulation Conditions on the Stimulation Effect of Noisy Galvanic Vestibular Stimulation

Subthreshold stochastic vestibular stimulation affects balance-challenged standing and walking

Stimulating balance: recent advances in vestibular stimulation for balance and gait

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